138
8
Hall RD, Holden MA, Yeoman MM (1987) The accumulation of phenylpropanoid and capsaicinoid compounds in cell cultures and whole fruit of the chilli pepper, Capsicum frutescens mill. Plant Cell Tissue
Organ Cult 8(2):163–176. https://doi.org/10.1007/bf00043153
Harvell KP, Bosland PW (1997) The environment produces a significant effect on pungency of chilies. Hort
Sci 32:1292
Holland A, Kinnear S (2013) Interpreting the possible ecological role(s) of cyanotoxins: compounds for
competitive advantage and/or physiological aide? Mar Drugs 11(7):2239–2258. https://doi.
org/10.3390/md11072239
Islam MN, Khalil MI, Islam MA, Gan SH (2014) Toxic compounds in honey. J Appl Toxicol 34(7):733–742.
https://doi.org/10.1002/jat.2952
Jennings KR, Brown DG, Wright DP (1986) Methyllycaconitine, a naturally occurring insecticide with a high
affinity for the insect cholinergic receptor. Experientia 42(6):611–613. https://doi.org/10.1007/
bf01955557
Jordt S-E, Julius D (2002) Molecular basis for species-specific sensitivity to “hot” chili peppers. Cell
108(3):421–430. https://doi.org/10.1016/S0092-8674(02)00637-2
Kakemoto E, Okuyama E, Nagata K, Ozoe Y (1999) Interaction of anisatin with rat brain gammaaminobutyric acidA receptors: allosteric modulation by competitive antagonists. Biochem Pharmacol
58(4):617–621
Kamatou GPP, Vermaak I, Viljoen AM, Lawrence BM (2013) Menthol: a simple monoterpene with remarkable
biological properties. Phytochemistry 96:15–25. https://doi.org/10.1016/j.phytochem.2013.08.005
Karban R, Shiojiri K, Huntzinger M, McCall AC (2006) Damage-induced resistance in sagebrush: volatiles
are key to intra- and interplant communication. Ecology 87(4):922–930
Karban R, Wetzel WC, Shiojiri K, Ishizaki S, Ramirez SR, Blande JD (2014) Deciphering the language of plant
communication: volatile chemotypes of sagebrush. New Phytol 204(2):380–385. https://doi.
org/10.1111/nph.12887
Kellmann R, Mihali TK, Jeon YJ, Pickford R, Pomati F, Neilan BA (2008) Biosynthetic intermediate analysis
and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl Environ Microbiol
74(13):4044–4053. https://doi.org/10.1128/AEM.00353-08
Kennedy DO, Wightman EL (2011) Herbal extracts and phytochemicals: plant secondary metabolites and
the enhancement of human brain function. Adv Nutr 2(1):32–50. https://doi.org/10.3945/
an.110.000117
King H (1948) 394. Curare alkaloids. Part VIII. Examination of commercial curare, Chondrodendron tomentosum R and P and Anomospermum grandifolium eichl. J Chem Soc (Resumed):1945–1949. https://
doi.org/10.1039/JR9480001945
Krienitz L, Ballot A, Kotut K, Wiegand C, Putz S, Metcalf JS, Codd GA, Pflugmacher S (2003) Contribution of
hot spring cyanobacteria to the mysterious deaths of lesser flamingos at Lake Bogoria, Kenya. FEMS
Microbiol Ecol 43(2):141–148. https://doi.org/10.1111/j.1574-6941.2003.tb01053.x
Kudakasseril GJ, Staba EJ (1988) Insecticidal phytochemicals. https://doi.org/10.1016/B978-0-12-7150055.50038-8
Kumar P, Pandit SS, Steppuhn A, Baldwin IT (2014) Natural history-driven, plant-mediated RNAi-based
study reveals CYP6B46‘s role in a nicotine-mediated antipredator herbivore defense.
Proc Natl Acad Sci 111(4):1245–1252. https://doi.org/10.1073/pnas.1314848111
Lashley KS (1917) The effects of strychnine and caffeine upon the rate of learning. Psychobiology 1.
https://doi.org/10.1037/h0075094
Lin Y, Qasim M, Hussain M, Akutse K, Avery P, Dash C, Wang L (2017) The herbivore-induced plant volatiles
methyl salicylate and menthol positively affect growth and pathogenicity of entomopathogenic
fungi. Sci Rep:7, 40494. https://doi.org/10.1038/srep40494
Ma LJ, Gu RH, Tang L, Chen ZE, Di R, Long CL (2015) Important poisonous plants in tibetan ethnomedicine.
Toxins (Basel) 7(1):138–155. https://doi.org/10.3390/toxins7010138
Mauck WL, Olson LE (1976) Toxicity of natural pyrethrins and five pyrethroids to fish. Arch Environ Contam
Toxicol 4(1):18–29
McGaugh JL, Roozendaal B (2009) Drug enhancement of memory consolidation: historical perspective
and neurobiological implications. Psychopharmacology 202(1):3–14. https://doi.org/10.1007/
s00213-008-1285-6
McLaughlin GA (1973) Chapter 1 – history of pyrethrum A2 - CASIDA. In: John E (ed) Pyrethrum. Academic
Press, New York, pp 3–15. https://doi.org/10.1016/B978-0-12-162950-2.50008-9
Chapter 8 · Plant-Derived Drugs Affecting Ion Channels
8
Hall RD, Holden MA, Yeoman MM (1987) The accumulation of phenylpropanoid and capsaicinoid compounds in cell cultures and whole fruit of the chilli pepper, Capsicum frutescens mill. Plant Cell Tissue
Organ Cult 8(2):163–176. https://doi.org/10.1007/bf00043153
Harvell KP, Bosland PW (1997) The environment produces a significant effect on pungency of chilies. Hort
Sci 32:1292
Holland A, Kinnear S (2013) Interpreting the possible ecological role(s) of cyanotoxins: compounds for
competitive advantage and/or physiological aide? Mar Drugs 11(7):2239–2258. https://doi.
org/10.3390/md11072239
Islam MN, Khalil MI, Islam MA, Gan SH (2014) Toxic compounds in honey. J Appl Toxicol 34(7):733–742.
https://doi.org/10.1002/jat.2952
Jennings KR, Brown DG, Wright DP (1986) Methyllycaconitine, a naturally occurring insecticide with a high
affinity for the insect cholinergic receptor. Experientia 42(6):611–613. https://doi.org/10.1007/
bf01955557
Jordt S-E, Julius D (2002) Molecular basis for species-specific sensitivity to “hot” chili peppers. Cell
108(3):421–430. https://doi.org/10.1016/S0092-8674(02)00637-2
Kakemoto E, Okuyama E, Nagata K, Ozoe Y (1999) Interaction of anisatin with rat brain gammaaminobutyric acidA receptors: allosteric modulation by competitive antagonists. Biochem Pharmacol
58(4):617–621
Kamatou GPP, Vermaak I, Viljoen AM, Lawrence BM (2013) Menthol: a simple monoterpene with remarkable
biological properties. Phytochemistry 96:15–25. https://doi.org/10.1016/j.phytochem.2013.08.005
Karban R, Shiojiri K, Huntzinger M, McCall AC (2006) Damage-induced resistance in sagebrush: volatiles
are key to intra- and interplant communication. Ecology 87(4):922–930
Karban R, Wetzel WC, Shiojiri K, Ishizaki S, Ramirez SR, Blande JD (2014) Deciphering the language of plant
communication: volatile chemotypes of sagebrush. New Phytol 204(2):380–385. https://doi.
org/10.1111/nph.12887
Kellmann R, Mihali TK, Jeon YJ, Pickford R, Pomati F, Neilan BA (2008) Biosynthetic intermediate analysis
and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl Environ Microbiol
74(13):4044–4053. https://doi.org/10.1128/AEM.00353-08
Kennedy DO, Wightman EL (2011) Herbal extracts and phytochemicals: plant secondary metabolites and
the enhancement of human brain function. Adv Nutr 2(1):32–50. https://doi.org/10.3945/
an.110.000117
King H (1948) 394. Curare alkaloids. Part VIII. Examination of commercial curare, Chondrodendron tomentosum R and P and Anomospermum grandifolium eichl. J Chem Soc (Resumed):1945–1949. https://
doi.org/10.1039/JR9480001945
Krienitz L, Ballot A, Kotut K, Wiegand C, Putz S, Metcalf JS, Codd GA, Pflugmacher S (2003) Contribution of
hot spring cyanobacteria to the mysterious deaths of lesser flamingos at Lake Bogoria, Kenya. FEMS
Microbiol Ecol 43(2):141–148. https://doi.org/10.1111/j.1574-6941.2003.tb01053.x
Kudakasseril GJ, Staba EJ (1988) Insecticidal phytochemicals. https://doi.org/10.1016/B978-0-12-7150055.50038-8
Kumar P, Pandit SS, Steppuhn A, Baldwin IT (2014) Natural history-driven, plant-mediated RNAi-based
study reveals CYP6B46‘s role in a nicotine-mediated antipredator herbivore defense.
Proc Natl Acad Sci 111(4):1245–1252. https://doi.org/10.1073/pnas.1314848111
Lashley KS (1917) The effects of strychnine and caffeine upon the rate of learning. Psychobiology 1.
https://doi.org/10.1037/h0075094
Lin Y, Qasim M, Hussain M, Akutse K, Avery P, Dash C, Wang L (2017) The herbivore-induced plant volatiles
methyl salicylate and menthol positively affect growth and pathogenicity of entomopathogenic
fungi. Sci Rep:7, 40494. https://doi.org/10.1038/srep40494
Ma LJ, Gu RH, Tang L, Chen ZE, Di R, Long CL (2015) Important poisonous plants in tibetan ethnomedicine.
Toxins (Basel) 7(1):138–155. https://doi.org/10.3390/toxins7010138
Mauck WL, Olson LE (1976) Toxicity of natural pyrethrins and five pyrethroids to fish. Arch Environ Contam
Toxicol 4(1):18–29
McGaugh JL, Roozendaal B (2009) Drug enhancement of memory consolidation: historical perspective
and neurobiological implications. Psychopharmacology 202(1):3–14. https://doi.org/10.1007/
s00213-008-1285-6
McLaughlin GA (1973) Chapter 1 – history of pyrethrum A2 - CASIDA. In: John E (ed) Pyrethrum. Academic
Press, New York, pp 3–15. https://doi.org/10.1016/B978-0-12-162950-2.50008-9
Chapter 8 · Plant-Derived Drugs Affecting Ion Channels