117
7
Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special
reference to factors that contribute to its widespread use. Pharmacol Rev 51(1):83–133
Friedman J, Waller GR (1983) Caffeine hazards and their prevention in germinating seeds of coffee (Coffea
arabica L.). J Chem Ecol 9(8):1099–1106. https://doi.org/10.1007/bf00982214
Gaoni Y, Mechoulam R (1964) Isolation, structure, and partial synthesis of an active constituent of hashish.
J Am Chem Soc 86(8):1646–1647. https://doi.org/10.1021/ja01062a046
Gertsch J, Raduner S, Altmann K-H (2006) New natural noncannabinoid ligands for cannabinoid type-2 (CB2)
receptors. J Recept Signal Transduct Res 26(5–6):709–730. https://doi.org/10.1080/10799890600942674
Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A (2008) Betacaryophyllene is a dietary cannabinoid. Proc Natl Acad Sci U S A 105(26):9099–9104
Gertsch J, Pertwee RG, Di Marzo V (2010) Phytocannabinoids beyond the Cannabis plant – do they exist?
Br J Pharmacol 160(3):523–529
Glick D, Glaubach S (1941) The occurrence and distribution of atropinesterase, and the specificity of tropinesterases. J Gen Physiol 25(2):197–205
Haller CA, Benowitz NL (2000) Adverse cardiovascular and central nervous system events associated with
dietary supplements containing ephedra alkaloids. N Engl J Med 343(25):1833–1838
Hasrat JA, DeBruyne T, DeBacker JP, Vauquelin G, Vlietinck AJ (1997) Cirsimarin and cirsimaritin, flavonoids
of Microtea debilis (phytolaccaceae) with adenosine antagonistic properties in rats: leads for new
therapeutics in acute renal failure. J Pharm Pharmacol 49(11):1150–1156
Hazslinsky B (1956) Toxische Wirkung eines Honigs der Tollkirsche (Atropa belladonna L.).
Z. Bienenforschung 3:93–96
Hofmann A (1980) LSD—my problem child. McGraw-Hill, New York
Hofmann A, Heim R, Brack A, Kobel H, Frey A, Ott H, Petrzilka T, Troxler F (1959) Psilocybin und Psilocin,
zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen. Helv Chim Acta 42(5):1557–1572.
https://doi.org/10.1002/hlca.19590420518
Holzman MD, Robert S (1998) The Legacy of atropos, the fate who cut the thread of life anesthesiology.
Anesthesiology 89(1):241–249
Huang RQ, O’Donnell AJ, Barboline JJ, Barkman TJ (2016) Convergent evolution of caffeine in plants by
co-option of exapted ancestral enzymes. Proc Natl Acad Sci U S A 113(38):10613–10618
Islam MN, Khalil MI, Islam MA, Gan SH (2014) Toxic compounds in honey. J Appl Toxicol 34(7):733–742.
https://doi.org/10.1002/jat.2952
Jacobson KA, Moro S, Manthey JA, West PL, Ji XD (2002) Interactions of flavones and other phytochemicals
with adenosine receptors. Adv Exp Med Biol 505:163–171
Jenkinson D (1986) Goodman and Gilman the pharmacological basis of therapeutics, 7th- Gilman AG,
Goodman LS, Rall TW, Murad F. Nature 319 (6056):802–803
Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang XH, Azuma M, Echigo N, Kemmotsu O, Hattori Y,
Gando S (2003) The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release? Anesth Analg 97(5):1239–1245
Kollner TG, Held M, Lenk C, Hiltpold I, Turlings TCJ, Gershenzon J, Degenhardt J (2008) A maize (E)-betacaryophyllene synthase implicated in indirect defense responses against herbivores is not expressed
in most American maize varieties. Plant Cell 20(2):482–494
Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SRW (2008) Caffeine induces Ca2+ release by reducing
the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem J 414:441–452
Korte G, Dreiseitel A, Schreier P, Oehme A, Locher S, Geiger S, Heilmann J, Sand PG (2010) Tea catechins’
affinity for human cannabinoid receptors. Phytomedicine 17(1):19–22. https://doi.org/10.1016/j.phymed.2009.10.001
Kuganathan N, Ganeshalingam S (2011) Chemical analysis of Datura Metel leaves and investigation of
the acute toxicity on grasshoppers and red ants. J Chem 8(1):107–112. https://doi.
org/10.1155/2011/714538
Kutchan TM, Ayabe S, Coscia CJ (1985) Cytodifferentiation and papaver alkaloid accumulation. In: The
chemistry and biology of Isoquinoline alkaloids. Springer, Berlin Heidelberg, pp 281–294
Ladenburg A (1881) Die natürlich vorkommenden mydriatisch wirkenden Alkaloïde. Justus Liebigs Ann
Chem 206(3):274–307. https://doi.org/10.1002/jlac.18812060303
Leonti M, Casu L, Raduner S, Cottiglia F, Floris C, Altmann KH, Gertsch J (2010) Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol
79(12):1815–1826
References
7
Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special
reference to factors that contribute to its widespread use. Pharmacol Rev 51(1):83–133
Friedman J, Waller GR (1983) Caffeine hazards and their prevention in germinating seeds of coffee (Coffea
arabica L.). J Chem Ecol 9(8):1099–1106. https://doi.org/10.1007/bf00982214
Gaoni Y, Mechoulam R (1964) Isolation, structure, and partial synthesis of an active constituent of hashish.
J Am Chem Soc 86(8):1646–1647. https://doi.org/10.1021/ja01062a046
Gertsch J, Raduner S, Altmann K-H (2006) New natural noncannabinoid ligands for cannabinoid type-2 (CB2)
receptors. J Recept Signal Transduct Res 26(5–6):709–730. https://doi.org/10.1080/10799890600942674
Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A (2008) Betacaryophyllene is a dietary cannabinoid. Proc Natl Acad Sci U S A 105(26):9099–9104
Gertsch J, Pertwee RG, Di Marzo V (2010) Phytocannabinoids beyond the Cannabis plant – do they exist?
Br J Pharmacol 160(3):523–529
Glick D, Glaubach S (1941) The occurrence and distribution of atropinesterase, and the specificity of tropinesterases. J Gen Physiol 25(2):197–205
Haller CA, Benowitz NL (2000) Adverse cardiovascular and central nervous system events associated with
dietary supplements containing ephedra alkaloids. N Engl J Med 343(25):1833–1838
Hasrat JA, DeBruyne T, DeBacker JP, Vauquelin G, Vlietinck AJ (1997) Cirsimarin and cirsimaritin, flavonoids
of Microtea debilis (phytolaccaceae) with adenosine antagonistic properties in rats: leads for new
therapeutics in acute renal failure. J Pharm Pharmacol 49(11):1150–1156
Hazslinsky B (1956) Toxische Wirkung eines Honigs der Tollkirsche (Atropa belladonna L.).
Z. Bienenforschung 3:93–96
Hofmann A (1980) LSD—my problem child. McGraw-Hill, New York
Hofmann A, Heim R, Brack A, Kobel H, Frey A, Ott H, Petrzilka T, Troxler F (1959) Psilocybin und Psilocin,
zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen. Helv Chim Acta 42(5):1557–1572.
https://doi.org/10.1002/hlca.19590420518
Holzman MD, Robert S (1998) The Legacy of atropos, the fate who cut the thread of life anesthesiology.
Anesthesiology 89(1):241–249
Huang RQ, O’Donnell AJ, Barboline JJ, Barkman TJ (2016) Convergent evolution of caffeine in plants by
co-option of exapted ancestral enzymes. Proc Natl Acad Sci U S A 113(38):10613–10618
Islam MN, Khalil MI, Islam MA, Gan SH (2014) Toxic compounds in honey. J Appl Toxicol 34(7):733–742.
https://doi.org/10.1002/jat.2952
Jacobson KA, Moro S, Manthey JA, West PL, Ji XD (2002) Interactions of flavones and other phytochemicals
with adenosine receptors. Adv Exp Med Biol 505:163–171
Jenkinson D (1986) Goodman and Gilman the pharmacological basis of therapeutics, 7th- Gilman AG,
Goodman LS, Rall TW, Murad F. Nature 319 (6056):802–803
Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang XH, Azuma M, Echigo N, Kemmotsu O, Hattori Y,
Gando S (2003) The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release? Anesth Analg 97(5):1239–1245
Kollner TG, Held M, Lenk C, Hiltpold I, Turlings TCJ, Gershenzon J, Degenhardt J (2008) A maize (E)-betacaryophyllene synthase implicated in indirect defense responses against herbivores is not expressed
in most American maize varieties. Plant Cell 20(2):482–494
Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SRW (2008) Caffeine induces Ca2+ release by reducing
the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem J 414:441–452
Korte G, Dreiseitel A, Schreier P, Oehme A, Locher S, Geiger S, Heilmann J, Sand PG (2010) Tea catechins’
affinity for human cannabinoid receptors. Phytomedicine 17(1):19–22. https://doi.org/10.1016/j.phymed.2009.10.001
Kuganathan N, Ganeshalingam S (2011) Chemical analysis of Datura Metel leaves and investigation of
the acute toxicity on grasshoppers and red ants. J Chem 8(1):107–112. https://doi.
org/10.1155/2011/714538
Kutchan TM, Ayabe S, Coscia CJ (1985) Cytodifferentiation and papaver alkaloid accumulation. In: The
chemistry and biology of Isoquinoline alkaloids. Springer, Berlin Heidelberg, pp 281–294
Ladenburg A (1881) Die natürlich vorkommenden mydriatisch wirkenden Alkaloïde. Justus Liebigs Ann
Chem 206(3):274–307. https://doi.org/10.1002/jlac.18812060303
Leonti M, Casu L, Raduner S, Cottiglia F, Floris C, Altmann KH, Gertsch J (2010) Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol
79(12):1815–1826
References