94
6
References
Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40:297–309
Bormann J (2000) The ‘ABC’ of GABA receptors. Trends Pharmacol Sci 21:16–19
Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C (2011) A structural
and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cysloop receptors. PLoS Biol 9:e1001034
Brito R, Sheth S, Mukherjea D, Rybak LP, Ramkumar V (2014) TRPV1: a potential drug target for treating
various diseases. Cell 3:517–545
Cestele S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium
channels. Biochimie 82:883–892
Cioffi CL (2013) Modulation of NMDA receptor function as a treatment for schizophrenia. Bioorg Med
Chem Lett 23:5034–5044
Daly JW (2005) Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol
25:513–552
Hayashi T (1954) effects of sodium glutamate on the nervous system. Keio J Med 3(4):183–192
Hold KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE (2000) Alpha-thujone (the active component of
absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc
Natl Acad Sci U S A 97:3826–3831
Johnston GA (2014) Muscimol as an ionotropic GABA receptor agonist. Neurochem Res 39:1942–1947
. Table 6.1 Summary of ion channels as targets for plant-derived drugs
Ion channels
Endogenous ligand/
activator
Plant-derived drugs
Major mode of drug
action
Nicotinic acetylcholine receptor NAchR
Acetylcholine
Nicotine
Cytisine
Curare alkaloids
Coniine
Physostigmine
Agonist
Agonist
Antagonists
Antagonist
Acetylcholine esterase
Inhibitor
GABA A receptor
GABA
Muscimol
Cicutoxin
Valerenic acid
Thujone
Anistatin
Bicuculline
Agonist
Antagonist
Allosteric positive
Allosteric negative
Allosteric negative
Allosteric negative
Glycine receptor
Glycine
Strychnine
Tutin
Antagonist
Antagonist
NMDA receptor
Kainate receptor
AMPA receptor
Glutamate
Ibotenic acid
Antagonist
TRPV1 channel
Voltage
heat
Capsaicin
Allosteric positive
TRPM8 channel
Voltage
cold
Menthol
Allosteric positive
Voltage-gated Na +
channel
Voltage
Aconitine
Persistent activation
Ryanodine receptor
Ca 2+
Ryanodine
Channel closure
Chapter 6 · Ion Channels as Targets for Plant-Derived Drugs
6
References
Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40:297–309
Bormann J (2000) The ‘ABC’ of GABA receptors. Trends Pharmacol Sci 21:16–19
Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C (2011) A structural
and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cysloop receptors. PLoS Biol 9:e1001034
Brito R, Sheth S, Mukherjea D, Rybak LP, Ramkumar V (2014) TRPV1: a potential drug target for treating
various diseases. Cell 3:517–545
Cestele S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium
channels. Biochimie 82:883–892
Cioffi CL (2013) Modulation of NMDA receptor function as a treatment for schizophrenia. Bioorg Med
Chem Lett 23:5034–5044
Daly JW (2005) Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol
25:513–552
Hayashi T (1954) effects of sodium glutamate on the nervous system. Keio J Med 3(4):183–192
Hold KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE (2000) Alpha-thujone (the active component of
absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc
Natl Acad Sci U S A 97:3826–3831
Johnston GA (2014) Muscimol as an ionotropic GABA receptor agonist. Neurochem Res 39:1942–1947
. Table 6.1 Summary of ion channels as targets for plant-derived drugs
Ion channels
Endogenous ligand/
activator
Plant-derived drugs
Major mode of drug
action
Nicotinic acetylcholine receptor NAchR
Acetylcholine
Nicotine
Cytisine
Curare alkaloids
Coniine
Physostigmine
Agonist
Agonist
Antagonists
Antagonist
Acetylcholine esterase
Inhibitor
GABA A receptor
GABA
Muscimol
Cicutoxin
Valerenic acid
Thujone
Anistatin
Bicuculline
Agonist
Antagonist
Allosteric positive
Allosteric negative
Allosteric negative
Allosteric negative
Glycine receptor
Glycine
Strychnine
Tutin
Antagonist
Antagonist
NMDA receptor
Kainate receptor
AMPA receptor
Glutamate
Ibotenic acid
Antagonist
TRPV1 channel
Voltage
heat
Capsaicin
Allosteric positive
TRPM8 channel
Voltage
cold
Menthol
Allosteric positive
Voltage-gated Na +
channel
Voltage
Aconitine
Persistent activation
Ryanodine receptor
Ca 2+
Ryanodine
Channel closure
Chapter 6 · Ion Channels as Targets for Plant-Derived Drugs