Speijers, G.J., Danse, L.H., Beuvery, E.C., Derks, H.J., Vos, J.G. (1988) Local reactions of Zwittergent-containing
meningococcal vaccine after intramuscular injection in rats: comparison with the effect of diphtheria-pertussistetanus-polio vaccine. Vaccine 6:419–422.
Speijers, G.J., Danse, L.H., Krajnc-Franken, M.A., van Leeuwen, F.X., Helleman, P.W., Beuvery, E.C., Vos, J.G., vd
Heijden, C.A. (1989) Subacute toxicity of Zwittergent administered intramuscularly. Vaccine 7:364–368.
Stangl, M., Unger, S., Keller, S., Schneider, D. (2014) Sequence-specific dimerization of a transmembrane helix in
amphipol A8-35. PLOS One 9:e110970.
Stephens, R.S., Sanchez-Pescador, R., Wagar, E.A., Inouye, C., Urdea, M.S. (1987) Diversity of Chlamydia trachomatis
major outer membrane protein genes. J. Bact. 169:3879–3885.
Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R.L.,
Zhao, Q., Koonin, E.V., Davis, R.W. (1998) Genome sequence of an obligate intracellular pathogen of humans:
Chlamydia trachomatis. Science 282:754–759.
Su, H., Caldwell, H.D. (1992) Immunogenicity of a chimeric peptide corresponding to T helper and B cell epitopes of the
Chlamydia trachomatis major outer membrane protein. J. Exp. Med. 175:227–235.
Suárez-Suárez, S., Carriedo, G.A., Presa Soto, A. (2013) Gold-decorated chiral macroporous films by the self-assembly
of functionalised block copolymers. Chem. Eur. J. 19:15933–15940.
Sun, G., Pal, S., Sarcon, A.K., Kim, S., Sugawara, E., Nikaido, H., Cocco, M.J., Peterson, E.M., de la Maza, L.M. (2007)
Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J. Bacteriol.
189:6222–6235.
Sun, G., Pal, S., Weiland, J., Peterson, E.M., de la Maza, L.M. (2009) Protection against an intranasal challenge by
vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane
protein. Vaccine 27:5020–5025.
Suzich, J.A., Ghim, S.J., Palmer-Hill, F.J., White, W.I., Tamura, J.K., Bell, J.A., Newsome, J.A., Jenson, A.B., Schlegel,
R. (1995) Systemic immunization with papillomavirus L1 protein completely prevents the development of viral
mucosal papillomas. Proc. Natl. Acad. Sci. USA 92:11553–11557.
Tifrea, D.F., Sun, G., Pal, S., Zardeneta, G., Cocco, M.J., Popot, J.-L., de la Maza, L.M. (2011) Amphipols stabilize the
Chlamydia major outer membrane protein and enhance its protective ability as a vaccine. Vaccine 29:4623–4631.
Tifrea, D., Pal, S., Cocco, M.J., Popot, J.-L., de la Maza, L.M. (2014) Increased immunoaccessibility of MOMP epitopes
in a vaccine formulated with amphipols may account for the very robust protection elicited against a vaginal challenge
with C. muridarum. J. Immunol. 192:5201–5213.
Tifrea, D.F., Pal, S., Le Bon, C., Giusti, F., Cocco, M.J., Zoonens, M., de la Maza, L.M. (2018a) Resiquimod conjugated
with Amphipols bound to the Chlamydia muridarum MOMP enhances protection against a mucosal challenge.
In preparation.
Tifrea, D.F., Pal, S., Le Bon, C., Giusti, F., Popot, J.-L., Cocco, M.J., Zoonens, M., de la Maza, L.M. (2018b) Co-delivery
of amphipol-conjugated adjuvant with antigen, and adjuvant combinations, enhance immune protection elicited by a
membrane protein-based vaccine against a mucosal challenge with Chlamydia. Submitted for publication.
Tighe, H., Takabayashi, K., Schwartz, D., Marsden, R., Beck, L., Corbeil, J., Richman, D.D., Eiden, J.J., Jr., Spiegelberg,
H.L., Raz, E. (2000) Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent
induction of cell-mediated and humoral immunity. Eur. J. Immunol. 30:1939–1947.
Trimaille, T., Verrier, B. (2015) Micelle-based adjuvants for subunit vaccine delivery. Vaccines (Basel) 3:803–813.
Vartak, A., Sucheck, S.J. (2016) Recent advances in subunit vaccine carriers. Vaccines (Basel) 4:pii: E12.
Vij, R., Lin, Z., Chiang, N., Vernes, J.M., Storek, K.M., Park, S., Chan, J., Meng, G., Comps-Agrar, L., Luan, P., Lee, S.,
Schneider, K., Bevers III, J., Zilberleyb, I., Tam, C., Koth, C.M., Xu, M., Gill, A., Auerbach, M.R., Smith, P.A.,
Rutherford, S.T., Nakamura, G., Seshasayee, D., Payandeh, J., Koerber, J.T. (2018) A targeted boost-and-sort
immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies. Sci. Rep. 8:7136.
Watkinson, T.G., Calabrese, A.N., Ault, J.R., Radford, S.E., Ashcroft, A.E. (2017) FPOP-LC-MS/MS suggests
differences in interaction sites of amphipols and detergents with outer membrane proteins. J. Am. Soc. Mass
Spectrom. 28:50–55.
Wua, J.J., Huang, D.B., Tyring, S.K. (2004) Resiquimod: a new immune response modifier with potential as a vaccine
adjuvant for Th1 immune responses. Antiviral Res. 64:79–83.
Yue, H., Ma, G. (2015) Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications.
Vaccine 33:5927–5936.
Zom, G.G., Khan, S., Filippov, D.V., Ossendorp, F. (2012) TLR ligand-peptide conjugate vaccines: Toward clinical
application. Adv. Immunol. 114:177–201.
682
15 Biomedical Applications
meningococcal vaccine after intramuscular injection in rats: comparison with the effect of diphtheria-pertussistetanus-polio vaccine. Vaccine 6:419–422.
Speijers, G.J., Danse, L.H., Krajnc-Franken, M.A., van Leeuwen, F.X., Helleman, P.W., Beuvery, E.C., Vos, J.G., vd
Heijden, C.A. (1989) Subacute toxicity of Zwittergent administered intramuscularly. Vaccine 7:364–368.
Stangl, M., Unger, S., Keller, S., Schneider, D. (2014) Sequence-specific dimerization of a transmembrane helix in
amphipol A8-35. PLOS One 9:e110970.
Stephens, R.S., Sanchez-Pescador, R., Wagar, E.A., Inouye, C., Urdea, M.S. (1987) Diversity of Chlamydia trachomatis
major outer membrane protein genes. J. Bact. 169:3879–3885.
Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R.L.,
Zhao, Q., Koonin, E.V., Davis, R.W. (1998) Genome sequence of an obligate intracellular pathogen of humans:
Chlamydia trachomatis. Science 282:754–759.
Su, H., Caldwell, H.D. (1992) Immunogenicity of a chimeric peptide corresponding to T helper and B cell epitopes of the
Chlamydia trachomatis major outer membrane protein. J. Exp. Med. 175:227–235.
Suárez-Suárez, S., Carriedo, G.A., Presa Soto, A. (2013) Gold-decorated chiral macroporous films by the self-assembly
of functionalised block copolymers. Chem. Eur. J. 19:15933–15940.
Sun, G., Pal, S., Sarcon, A.K., Kim, S., Sugawara, E., Nikaido, H., Cocco, M.J., Peterson, E.M., de la Maza, L.M. (2007)
Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J. Bacteriol.
189:6222–6235.
Sun, G., Pal, S., Weiland, J., Peterson, E.M., de la Maza, L.M. (2009) Protection against an intranasal challenge by
vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane
protein. Vaccine 27:5020–5025.
Suzich, J.A., Ghim, S.J., Palmer-Hill, F.J., White, W.I., Tamura, J.K., Bell, J.A., Newsome, J.A., Jenson, A.B., Schlegel,
R. (1995) Systemic immunization with papillomavirus L1 protein completely prevents the development of viral
mucosal papillomas. Proc. Natl. Acad. Sci. USA 92:11553–11557.
Tifrea, D.F., Sun, G., Pal, S., Zardeneta, G., Cocco, M.J., Popot, J.-L., de la Maza, L.M. (2011) Amphipols stabilize the
Chlamydia major outer membrane protein and enhance its protective ability as a vaccine. Vaccine 29:4623–4631.
Tifrea, D., Pal, S., Cocco, M.J., Popot, J.-L., de la Maza, L.M. (2014) Increased immunoaccessibility of MOMP epitopes
in a vaccine formulated with amphipols may account for the very robust protection elicited against a vaginal challenge
with C. muridarum. J. Immunol. 192:5201–5213.
Tifrea, D.F., Pal, S., Le Bon, C., Giusti, F., Cocco, M.J., Zoonens, M., de la Maza, L.M. (2018a) Resiquimod conjugated
with Amphipols bound to the Chlamydia muridarum MOMP enhances protection against a mucosal challenge.
In preparation.
Tifrea, D.F., Pal, S., Le Bon, C., Giusti, F., Popot, J.-L., Cocco, M.J., Zoonens, M., de la Maza, L.M. (2018b) Co-delivery
of amphipol-conjugated adjuvant with antigen, and adjuvant combinations, enhance immune protection elicited by a
membrane protein-based vaccine against a mucosal challenge with Chlamydia. Submitted for publication.
Tighe, H., Takabayashi, K., Schwartz, D., Marsden, R., Beck, L., Corbeil, J., Richman, D.D., Eiden, J.J., Jr., Spiegelberg,
H.L., Raz, E. (2000) Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent
induction of cell-mediated and humoral immunity. Eur. J. Immunol. 30:1939–1947.
Trimaille, T., Verrier, B. (2015) Micelle-based adjuvants for subunit vaccine delivery. Vaccines (Basel) 3:803–813.
Vartak, A., Sucheck, S.J. (2016) Recent advances in subunit vaccine carriers. Vaccines (Basel) 4:pii: E12.
Vij, R., Lin, Z., Chiang, N., Vernes, J.M., Storek, K.M., Park, S., Chan, J., Meng, G., Comps-Agrar, L., Luan, P., Lee, S.,
Schneider, K., Bevers III, J., Zilberleyb, I., Tam, C., Koth, C.M., Xu, M., Gill, A., Auerbach, M.R., Smith, P.A.,
Rutherford, S.T., Nakamura, G., Seshasayee, D., Payandeh, J., Koerber, J.T. (2018) A targeted boost-and-sort
immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies. Sci. Rep. 8:7136.
Watkinson, T.G., Calabrese, A.N., Ault, J.R., Radford, S.E., Ashcroft, A.E. (2017) FPOP-LC-MS/MS suggests
differences in interaction sites of amphipols and detergents with outer membrane proteins. J. Am. Soc. Mass
Spectrom. 28:50–55.
Wua, J.J., Huang, D.B., Tyring, S.K. (2004) Resiquimod: a new immune response modifier with potential as a vaccine
adjuvant for Th1 immune responses. Antiviral Res. 64:79–83.
Yue, H., Ma, G. (2015) Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications.
Vaccine 33:5927–5936.
Zom, G.G., Khan, S., Filippov, D.V., Ossendorp, F. (2012) TLR ligand-peptide conjugate vaccines: Toward clinical
application. Adv. Immunol. 114:177–201.
682
15 Biomedical Applications