Igietseme, J.U., Eko, F.O., Black, C.M. (2011) Chlamydia vaccines: recent developments and the role of adjuvants in
future formulations. Expert Rev. Vaccines 10:1585–1596.
Ilyinskii, P.O., Roy, C.J., O’Neil, C.P., Browning, E.A., Pittet, L.A., Altreutera, D.H., Alexis, F., Tonti, E., Shi, J., Basto,
P.A., Iannaconec, M., Radovic-Moreno, A.F., Langer, R.S., Farokhzad, O.C., von Andrian, U.H., Johnston, L.P.M.,
Kishimoto, T.K. (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated
antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine
32:2882–2895.
Ionescu-Matiu, I., Kennedy, R.C., Sparrow, J.T., Culwell, A.R., Sanchez, Y., Melnick, J.L., Dreesman, G.R. (1983)
Epitopes associated with a synthetic hepatitis B surface antigen peptide. J. Immunol. 130:1947–1952.
Jacob, L., Sawma, P., Garnier, N., Meyer, L.A.T., Fritz, J., Hussenet, T., Spenlé, C., Goetz, J., Vermot, J., Fernandez, A.,
Baumlin, N., Aci-Sèche, S., Orend, G., Roussel, G., Crémel, G., Genest, M., Hubert, P., Bagnard, D. (2016)
Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane
domain targeting peptide. Oncotarget 7:57851–57865.
Kari, L., Whitmire, W.M., Crane, D.D., Reveneau, N., Carlson, J.H., Goheen, M.M., Peterson, E.M., Pal, S., de la Maza,
L.M., Caldwell, H.D. (2009) Chlamydia trachomatis native major outer membrane protein induces partial protection
in nonhuman primates: implication for a trachoma transmission-blocking vaccine. J. Immunol. 182:8063–8070.
Keller, S., Wilson, J.T., Patilea, G.I., Kern, H.B., Convertine, A.J., Stayton, P.S. (2014) Neutral polymer micelle carriers
with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8
+ T cell responses.
J. Control. Release 191:24–33.
Kim, D., Park, J.-H., Kweon, D.-J., Han, G.D. (2013) Bioavailability of nanoemulsified conjugated linoleic acid for an
antiobesity effect. Int. J. Nanomedicine 8:451–459.
Kushnir, N., Streatfield, S.J., Yusibov, V. (2012) Virus-like particles as a highly efficient vaccine platform: diversity of
targets and production systems and advances in clinical development. Vaccine 31:58–83.
Le Bon, C., Della Pia, E.A., Giusti, F., Lloret, N., Zoonens, M., Martinez, K.L., Popot, J.-L. (2014a) Synthesis of an
oligonucleotide-derivatized amphipol and its use to trap and immobilize membrane proteins. Nucleic Acids Res. 42:
e83.
Le Bon, C., Popot, J.-L., Giusti, F. (2014b) Labeling and functionalizing amphipols for biological applications.
J. Membr. Biol. 247:797–814.
Levine, M.M., Dougan, G., Good, M.F., Liu, M.A., Nabel, G.J., Nataro, J.P., Rappuoli, R. (2010) New Generation
Vaccines, 4th ed., Informa Healthcare, New York, N.Y., 1040 p.
Li, W., Szoka, F., Jr. (2007) Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24:438–449.
Li, J.P., Ouyang, Y.Y., Kong, X., Zhu, J.Y., Lu, D.N., Liu, Z. (2015) A multi-scale molecular dynamics simulation of
PMAL facilitated delivery of siRNA. RSC Adv. 5:68227–68233.
Liu, G., Luo, Q., Gao, H., Chen, Y., Wei, X., Dai, H., Zhang, Z., Ji, J. (2015) Cell membrane-inspired polymeric micelles
as carriers for drug delivery. Biomater Sci. 3:490–499.
MacKenzie, K.R. (2006) Folding and stability of alpha-helical integral membrane proteins. Chem. Rev. 106:1931–1977.
Manolova, V., Flace, A., Bauer, M., Schwarz, K., Saudan, P., Bachmann, M.F. (2008) Nanoparticles target distinct
dendritic cell populations according to their size. Eur. J. Immunol. 38:1404–1413.
Matthews, E.E., Zoonens, M., Engelman, D.M. (2006) Dynamic helix interactions in transmembrane signaling. Cell
127:447–450.
Maurer, T., Heit, A., Hochrein, H., Ampenberger, F., O’Keeffe, M., Bauer, S., Lipford, G.B., Vabulas, R.M., Wagner,
H. (2002) CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur. J. Immunol. 32:2356–2364.
de la Maza, L.M., Zhong, G., Brunham, R.C. (2017) Update on Chlamydia trachomatis vaccinology. Clinic. Vacc.
Immunol. 24:e00543–16.
Delany, I., Rappuoli, R., De Gregorio, E. (2014) Vaccines for the 21st century. EMBO Mol. Med. 6:708–720.
Della Pia, E.A., Holm, J., Lloret, N., Le Bon, C., Popot, J.-L., Zoonens, M., Nygård, J., Martinez, K.L. (2014) A step
closer to membrane protein multiplexed nano-arrays using biotin-doped polypyrrole. ACS Nano 8:1844–1853.
Mercado, S.A., Orellana-Tavra, C., Chen, A., Slater, N.K. (2016) The intracellular fate of an amphipathic pH-responsive
polymer: Key characteristics towards drug delivery. Mater. Sci. Eng. C. Mater. Biol. Appl. 69:1051–1057.
Miyabe, H., Hyodo, M., T.N.. Sato Y., Hayakawa, Y., Harashima, H. (2014) A new adjuvant delivery system ‘cyclic
di-GMP/YSK05 liposome’ for cancer immunotherapy. J. Control. Release 184:20–27.
Morrison, R.P., Caldwell, H.D. (2002) Immunity to murine chlamydial genital infection. Infect. Immun. 70:2741–2751.
Morrison, R.P., Belland, R.J., Lyng, K., Caldwell, H.D. (1989) Chlamydial disease pathogenesis. The 57-kD chlamydial
hypersensitivity antigen is a stress response protein. J. Exp. Med. 170:1271–1283.
Moyle, P.M., Toth, I. (2008) Self-adjuvanting lipopeptide vaccines. Curr. Med. Chem 15:506–516.
Moyle, P.M., Toth, I. (2013) Modern subunit vaccines: development, components, and research opportunities.
ChemMedChem 8:360–376.
Mutwiri, G., Gerdts, V., Van Drunen Littel-van den Hurk, S., Auray, G., Eng, N., Garlapati, S., Babiuk, L.A., Potter,
A. (2011) Combination adjuvants: the next generation of adjuvants? Expert Rev. Vaccines 10:95–107.
680
15 Biomedical Applications
future formulations. Expert Rev. Vaccines 10:1585–1596.
Ilyinskii, P.O., Roy, C.J., O’Neil, C.P., Browning, E.A., Pittet, L.A., Altreutera, D.H., Alexis, F., Tonti, E., Shi, J., Basto,
P.A., Iannaconec, M., Radovic-Moreno, A.F., Langer, R.S., Farokhzad, O.C., von Andrian, U.H., Johnston, L.P.M.,
Kishimoto, T.K. (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated
antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine
32:2882–2895.
Ionescu-Matiu, I., Kennedy, R.C., Sparrow, J.T., Culwell, A.R., Sanchez, Y., Melnick, J.L., Dreesman, G.R. (1983)
Epitopes associated with a synthetic hepatitis B surface antigen peptide. J. Immunol. 130:1947–1952.
Jacob, L., Sawma, P., Garnier, N., Meyer, L.A.T., Fritz, J., Hussenet, T., Spenlé, C., Goetz, J., Vermot, J., Fernandez, A.,
Baumlin, N., Aci-Sèche, S., Orend, G., Roussel, G., Crémel, G., Genest, M., Hubert, P., Bagnard, D. (2016)
Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane
domain targeting peptide. Oncotarget 7:57851–57865.
Kari, L., Whitmire, W.M., Crane, D.D., Reveneau, N., Carlson, J.H., Goheen, M.M., Peterson, E.M., Pal, S., de la Maza,
L.M., Caldwell, H.D. (2009) Chlamydia trachomatis native major outer membrane protein induces partial protection
in nonhuman primates: implication for a trachoma transmission-blocking vaccine. J. Immunol. 182:8063–8070.
Keller, S., Wilson, J.T., Patilea, G.I., Kern, H.B., Convertine, A.J., Stayton, P.S. (2014) Neutral polymer micelle carriers
with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8
+ T cell responses.
J. Control. Release 191:24–33.
Kim, D., Park, J.-H., Kweon, D.-J., Han, G.D. (2013) Bioavailability of nanoemulsified conjugated linoleic acid for an
antiobesity effect. Int. J. Nanomedicine 8:451–459.
Kushnir, N., Streatfield, S.J., Yusibov, V. (2012) Virus-like particles as a highly efficient vaccine platform: diversity of
targets and production systems and advances in clinical development. Vaccine 31:58–83.
Le Bon, C., Della Pia, E.A., Giusti, F., Lloret, N., Zoonens, M., Martinez, K.L., Popot, J.-L. (2014a) Synthesis of an
oligonucleotide-derivatized amphipol and its use to trap and immobilize membrane proteins. Nucleic Acids Res. 42:
e83.
Le Bon, C., Popot, J.-L., Giusti, F. (2014b) Labeling and functionalizing amphipols for biological applications.
J. Membr. Biol. 247:797–814.
Levine, M.M., Dougan, G., Good, M.F., Liu, M.A., Nabel, G.J., Nataro, J.P., Rappuoli, R. (2010) New Generation
Vaccines, 4th ed., Informa Healthcare, New York, N.Y., 1040 p.
Li, W., Szoka, F., Jr. (2007) Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24:438–449.
Li, J.P., Ouyang, Y.Y., Kong, X., Zhu, J.Y., Lu, D.N., Liu, Z. (2015) A multi-scale molecular dynamics simulation of
PMAL facilitated delivery of siRNA. RSC Adv. 5:68227–68233.
Liu, G., Luo, Q., Gao, H., Chen, Y., Wei, X., Dai, H., Zhang, Z., Ji, J. (2015) Cell membrane-inspired polymeric micelles
as carriers for drug delivery. Biomater Sci. 3:490–499.
MacKenzie, K.R. (2006) Folding and stability of alpha-helical integral membrane proteins. Chem. Rev. 106:1931–1977.
Manolova, V., Flace, A., Bauer, M., Schwarz, K., Saudan, P., Bachmann, M.F. (2008) Nanoparticles target distinct
dendritic cell populations according to their size. Eur. J. Immunol. 38:1404–1413.
Matthews, E.E., Zoonens, M., Engelman, D.M. (2006) Dynamic helix interactions in transmembrane signaling. Cell
127:447–450.
Maurer, T., Heit, A., Hochrein, H., Ampenberger, F., O’Keeffe, M., Bauer, S., Lipford, G.B., Vabulas, R.M., Wagner,
H. (2002) CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur. J. Immunol. 32:2356–2364.
de la Maza, L.M., Zhong, G., Brunham, R.C. (2017) Update on Chlamydia trachomatis vaccinology. Clinic. Vacc.
Immunol. 24:e00543–16.
Delany, I., Rappuoli, R., De Gregorio, E. (2014) Vaccines for the 21st century. EMBO Mol. Med. 6:708–720.
Della Pia, E.A., Holm, J., Lloret, N., Le Bon, C., Popot, J.-L., Zoonens, M., Nygård, J., Martinez, K.L. (2014) A step
closer to membrane protein multiplexed nano-arrays using biotin-doped polypyrrole. ACS Nano 8:1844–1853.
Mercado, S.A., Orellana-Tavra, C., Chen, A., Slater, N.K. (2016) The intracellular fate of an amphipathic pH-responsive
polymer: Key characteristics towards drug delivery. Mater. Sci. Eng. C. Mater. Biol. Appl. 69:1051–1057.
Miyabe, H., Hyodo, M., T.N.. Sato Y., Hayakawa, Y., Harashima, H. (2014) A new adjuvant delivery system ‘cyclic
di-GMP/YSK05 liposome’ for cancer immunotherapy. J. Control. Release 184:20–27.
Morrison, R.P., Caldwell, H.D. (2002) Immunity to murine chlamydial genital infection. Infect. Immun. 70:2741–2751.
Morrison, R.P., Belland, R.J., Lyng, K., Caldwell, H.D. (1989) Chlamydial disease pathogenesis. The 57-kD chlamydial
hypersensitivity antigen is a stress response protein. J. Exp. Med. 170:1271–1283.
Moyle, P.M., Toth, I. (2008) Self-adjuvanting lipopeptide vaccines. Curr. Med. Chem 15:506–516.
Moyle, P.M., Toth, I. (2013) Modern subunit vaccines: development, components, and research opportunities.
ChemMedChem 8:360–376.
Mutwiri, G., Gerdts, V., Van Drunen Littel-van den Hurk, S., Auray, G., Eng, N., Garlapati, S., Babiuk, L.A., Potter,
A. (2011) Combination adjuvants: the next generation of adjuvants? Expert Rev. Vaccines 10:95–107.
680
15 Biomedical Applications