References
Allison, T.M., Reading, E., Liko, I., Baldwin, A.J., Laganowsky, A., Robinson, C.V. (2015) Quantifying the stabilizing
effects of protein-ligand interactions in the gas phase. Nat. Comm. 6:8551.
Barrera, N.P., Di Bartolo, N., Booth, P.J., Robinson, C.V. (2008) Micelles protect membrane complexes from solution to
vacuum. Science 321:243–246.
Barrera, N.P., Isaacson, S.C., Zhou, M., Bavro, V.N., Welch, A., Schaedler, T.A., Seeger, M.A., Miguel, R.N., Korkhov,
V.M., van Veen, H.W., Venter, H., Walmsley, A.R., Tate, C.G., Robinson, C.V. (2009) Mass spectrometry of
membrane transporters reveals subunit stoichiometry and interactions. Nat. Meth. 6:585–587.
Barrera, N.P., Robinson, C.V. (2011) Advances in the mass spectrometry of membrane proteins: from individual proteins
to intact complexes. Annu. Rev. Biochem. 80:247–271.
Bazzacco, P., Billon-Denis, E., Sharma, K.S., Catoire, L.J., Mary, S., Le Bon, C., Point, E., Banères, J.-L., Durand, G.,
Zito, F., Pucci, B., Popot, J.-L. (2012) Non-ionic homopolymeric amphipols: Application to membrane protein
folding, cell-free synthesis, and solution NMR. Biochemistry 51:1416–1430.
Bechara, C., Bolbach, G., Bazzacco, P., Sharma, S.K., Durand, G., Popot, J.-L., Zito, F., Sagan, S. (2012) MALDI mass
spectrometry analysis of membrane protein/amphipol complexes. Anal. Chem. 84:6128–6135.
Bechara, C., Nöll, A., Morgner, N., Degiacomi, M.T., Tampé, R., Robinson, C.V. (2015) A subset of annular lipids is
linked to the flippase activity of an ABC transporter. Nat. Chem. 7:255–262.
Bechara, C., Robinson, C.V. (2015) Different modes of lipid binding to membrane proteins probed by mass spectrometry. J. Am. Chem. Soc. 137:5240–5247.
Benesch, J.L. (2009) Collisional activation of protein complexes: picking up the pieces. J. Am. Soc. Mass Spectrom.
20:341–348.
Berry, E.A., Guergova-Kuras, M., Huang, L.-S., Crofts, A.R. (2000) Structure and function of cytochrome bc 1
complexes. Annu. Rev. Biochem. 69:1005–1075.
Bleiholder, C., Wyttenbach, T., Bowers, M.T. (2011) A novel projection approximation algorithm for the fast and
accurate computation of molecular collision cross sections. (I) Method. Int. J. Mass Spectrom. 308:1–10.
Borysik, A.J., Hewitt, D.J., Robinson, C.V. (2013) Detergent release prolongs the lifetime of native-like membrane
protein conformations in the gas-phase. J. Am. Chem. Soc. 135:6078–6083.
Borysik, A.J., Robinson, C.V. (2012) The ‘sticky business’ of cleaning gas-phase membrane proteins: a detergent
oriented perspective. Phys. Chem. Chem. Phys. 14:14439–14449.
Botte, M., Zaccai, N.R., Lycklama à Nijeholt, J., Martin, R., Knoops, K., Papai, G., Zou, J., Deniaud, A., Karuppasamy,
M., Jiang, Q., Singha Roy, A., Schulten, K., Schultz, P., Rappsilber, J., Zaccai, G., Berger, I., Collinson, I.,
Schaffitzel, C. (2016) A central cavity within the holotranslocon suggests a mechanism for membrane protein
insertion. Sci. Rep. 6:38399.
Bush, M.F., Hall, Z., Giles, K., Hoyes, J., Robinson, C.V., Ruotolo, B.T. (2010) Collision cross-sections of proteins and
their complexes: A calibration framework and database for gas-phase structural biology. Anal. Chem. 82:9557–9565.
Cadene, M., Chait, B.T. (2000) A robust, detergent-friendly method for mass spectrometric analysis of integral
membrane proteins. Anal. Chem. 72:5655–5658.
Calabrese, A.N., Watkinson, T.G., Henderson, P.J.F., Radford, S.E., Ashcroft, A.E. (2015) Amphipols outperform
dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase. Anal. Chem. 87:1118–1126.
Catoire, L.J., Zoonens, M., van Heijenoort, C., Giusti, F., Popot, J.-L., Guittet, E. (2009) Inter- and intramolecular
contacts in a membrane protein/surfactant complex observed by heteronuclear dipole-to-dipole cross-relaxation.
J. Magn. Res. 197:91–95.
Champeil, P., Menguy, T., Tribet, C., Popot, J.-L., le Maire, M. (2000) Interaction of amphipols with the sarcoplasmic
reticulum Ca
2+ -ATPase. J. Biol. Chem. 275:18623–18637.
Dahmane, T., Giusti, F., Catoire, L.J., Popot, J.-L. (2011) Sulfonated amphipols: Synthesis, properties and applications.
Biopolymers 95:811–823.
Dörr, J.M., Scheidelaar, S., Koorengevel, M.C., Dominguez, J.J., Schäfer, M., van Walree, C.A., Killian, J.A. (2016) The
styrene-maleic acid copolymer: a versatile tool in membrane research. Eur. Biophys. J. 45:3–21.
Eschweiler, J.D., Rabuck-Gibbons, J.N., Tian, Y., Ruotolo, B.T. (2015) CIUSuite: A quantitative analysis package for
collision induced unfolding measurements of gas-phase protein ions. Anal. Chem. 87:11516–11522.
Etzkorn, M., Zoonens, M., Catoire, L.J., Popot, J.-L., Hiller, S. (2014) How amphipols embed membrane proteins:
Global solvent accessibility and interaction with a flexible protein terminus. J. Membr. Biol. 247:965–970.
Gault, J., Donlan, J.A.C., Liko, I., Hopper, J.T.S., Gupta, K., Housden, N.G., Struwe, W.B., Marty, M.T., Mize, T.,
Bechara, C., Zhu, Y., Wu, B., Kleanthous, C., Belov, M., Damoc, E., Makarov, A., Robinson, C.V. (2016) Highresolution mass spectrometry of small molecules bound to membrane proteins. Nat. Methods 13:333–336.
Giusti, F., Rieger, J., Catoire, L., Qian, S., Calabrese, A.N., Watkinson, T.G., Casiraghi, M., Radford, S.E., Ashcroft, A.
E., Popot, J.-L. (2014) Synthesis, characterization and applications of a perdeuterated amphipol. J. Membr. Biol.
247:909–924.
References
655
Allison, T.M., Reading, E., Liko, I., Baldwin, A.J., Laganowsky, A., Robinson, C.V. (2015) Quantifying the stabilizing
effects of protein-ligand interactions in the gas phase. Nat. Comm. 6:8551.
Barrera, N.P., Di Bartolo, N., Booth, P.J., Robinson, C.V. (2008) Micelles protect membrane complexes from solution to
vacuum. Science 321:243–246.
Barrera, N.P., Isaacson, S.C., Zhou, M., Bavro, V.N., Welch, A., Schaedler, T.A., Seeger, M.A., Miguel, R.N., Korkhov,
V.M., van Veen, H.W., Venter, H., Walmsley, A.R., Tate, C.G., Robinson, C.V. (2009) Mass spectrometry of
membrane transporters reveals subunit stoichiometry and interactions. Nat. Meth. 6:585–587.
Barrera, N.P., Robinson, C.V. (2011) Advances in the mass spectrometry of membrane proteins: from individual proteins
to intact complexes. Annu. Rev. Biochem. 80:247–271.
Bazzacco, P., Billon-Denis, E., Sharma, K.S., Catoire, L.J., Mary, S., Le Bon, C., Point, E., Banères, J.-L., Durand, G.,
Zito, F., Pucci, B., Popot, J.-L. (2012) Non-ionic homopolymeric amphipols: Application to membrane protein
folding, cell-free synthesis, and solution NMR. Biochemistry 51:1416–1430.
Bechara, C., Bolbach, G., Bazzacco, P., Sharma, S.K., Durand, G., Popot, J.-L., Zito, F., Sagan, S. (2012) MALDI mass
spectrometry analysis of membrane protein/amphipol complexes. Anal. Chem. 84:6128–6135.
Bechara, C., Nöll, A., Morgner, N., Degiacomi, M.T., Tampé, R., Robinson, C.V. (2015) A subset of annular lipids is
linked to the flippase activity of an ABC transporter. Nat. Chem. 7:255–262.
Bechara, C., Robinson, C.V. (2015) Different modes of lipid binding to membrane proteins probed by mass spectrometry. J. Am. Chem. Soc. 137:5240–5247.
Benesch, J.L. (2009) Collisional activation of protein complexes: picking up the pieces. J. Am. Soc. Mass Spectrom.
20:341–348.
Berry, E.A., Guergova-Kuras, M., Huang, L.-S., Crofts, A.R. (2000) Structure and function of cytochrome bc 1
complexes. Annu. Rev. Biochem. 69:1005–1075.
Bleiholder, C., Wyttenbach, T., Bowers, M.T. (2011) A novel projection approximation algorithm for the fast and
accurate computation of molecular collision cross sections. (I) Method. Int. J. Mass Spectrom. 308:1–10.
Borysik, A.J., Hewitt, D.J., Robinson, C.V. (2013) Detergent release prolongs the lifetime of native-like membrane
protein conformations in the gas-phase. J. Am. Chem. Soc. 135:6078–6083.
Borysik, A.J., Robinson, C.V. (2012) The ‘sticky business’ of cleaning gas-phase membrane proteins: a detergent
oriented perspective. Phys. Chem. Chem. Phys. 14:14439–14449.
Botte, M., Zaccai, N.R., Lycklama à Nijeholt, J., Martin, R., Knoops, K., Papai, G., Zou, J., Deniaud, A., Karuppasamy,
M., Jiang, Q., Singha Roy, A., Schulten, K., Schultz, P., Rappsilber, J., Zaccai, G., Berger, I., Collinson, I.,
Schaffitzel, C. (2016) A central cavity within the holotranslocon suggests a mechanism for membrane protein
insertion. Sci. Rep. 6:38399.
Bush, M.F., Hall, Z., Giles, K., Hoyes, J., Robinson, C.V., Ruotolo, B.T. (2010) Collision cross-sections of proteins and
their complexes: A calibration framework and database for gas-phase structural biology. Anal. Chem. 82:9557–9565.
Cadene, M., Chait, B.T. (2000) A robust, detergent-friendly method for mass spectrometric analysis of integral
membrane proteins. Anal. Chem. 72:5655–5658.
Calabrese, A.N., Watkinson, T.G., Henderson, P.J.F., Radford, S.E., Ashcroft, A.E. (2015) Amphipols outperform
dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase. Anal. Chem. 87:1118–1126.
Catoire, L.J., Zoonens, M., van Heijenoort, C., Giusti, F., Popot, J.-L., Guittet, E. (2009) Inter- and intramolecular
contacts in a membrane protein/surfactant complex observed by heteronuclear dipole-to-dipole cross-relaxation.
J. Magn. Res. 197:91–95.
Champeil, P., Menguy, T., Tribet, C., Popot, J.-L., le Maire, M. (2000) Interaction of amphipols with the sarcoplasmic
reticulum Ca
2+ -ATPase. J. Biol. Chem. 275:18623–18637.
Dahmane, T., Giusti, F., Catoire, L.J., Popot, J.-L. (2011) Sulfonated amphipols: Synthesis, properties and applications.
Biopolymers 95:811–823.
Dörr, J.M., Scheidelaar, S., Koorengevel, M.C., Dominguez, J.J., Schäfer, M., van Walree, C.A., Killian, J.A. (2016) The
styrene-maleic acid copolymer: a versatile tool in membrane research. Eur. Biophys. J. 45:3–21.
Eschweiler, J.D., Rabuck-Gibbons, J.N., Tian, Y., Ruotolo, B.T. (2015) CIUSuite: A quantitative analysis package for
collision induced unfolding measurements of gas-phase protein ions. Anal. Chem. 87:11516–11522.
Etzkorn, M., Zoonens, M., Catoire, L.J., Popot, J.-L., Hiller, S. (2014) How amphipols embed membrane proteins:
Global solvent accessibility and interaction with a flexible protein terminus. J. Membr. Biol. 247:965–970.
Gault, J., Donlan, J.A.C., Liko, I., Hopper, J.T.S., Gupta, K., Housden, N.G., Struwe, W.B., Marty, M.T., Mize, T.,
Bechara, C., Zhu, Y., Wu, B., Kleanthous, C., Belov, M., Damoc, E., Makarov, A., Robinson, C.V. (2016) Highresolution mass spectrometry of small molecules bound to membrane proteins. Nat. Methods 13:333–336.
Giusti, F., Rieger, J., Catoire, L., Qian, S., Calabrese, A.N., Watkinson, T.G., Casiraghi, M., Radford, S.E., Ashcroft, A.
E., Popot, J.-L. (2014) Synthesis, characterization and applications of a perdeuterated amphipol. J. Membr. Biol.
247:909–924.
References
655