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nonionic detergents destabilize G protein-coupled receptors? J. Am. Chem. Soc. 138:15425–15433.
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bundle. Biochemistry 40:6636–6645.
Liao, J., Li, H., Zeng, W., Sauer, D.B., Belmares, R., Jiang, Y. (2012) Structural insight into the ion-exchange
mechanism of the sodium/calcium exchanger. Science 335:686–690.
Lichtenberg, D., Ahyayauch, H., Goñi, F.M. (2013) The mechanism of detergent solubilization of lipid bilayers. Biophys.
J. 105:289–299.
Luecke, H., Schobert, B., Richter, H.-T., Cartailler, J.-P., Lanyi, J.K. (1999) Structure of bacteriorhodopsin at 1.55 Å
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91
californica. FEBS Lett. 108:155–160.
Hunte, C., Richers, S. (2008) Lipids and membrane protein structures. Curr. Opin. Struct. Biol. 18:406–411.
Hussain, H., Du, Y., Tikhonova, E., Mortensen, J.S., Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, C.J., Guan,
L., Kobilka, B.K., Byrne, B., Chae, P.S. (2017) Resorcinarene-based facial glycosides: Implication of detergent
flexibility on membrane-protein stability. Chemistry – Eur. J. 23:6724–6729.
Hutchison, J.M., Lu, Z., Li, G.C., Travis, B., Mittal, R., Deatherage, C.L., Sanders, C.R. (2017) Dodecyl-β-melibioside
detergent micelles as a medium for membrane proteins. Biochemistry 56:5481–5484.
Israelachvili, J.N. (2011) Intermolecular and Surface Forces, 3rd ed.. Elsevier/Academic Press, London, 706 p.
Keana, J.F., Roman, R.B. (1978) Improved synthesis of n-octyl-β-D-glucoside: a nonionic detergent of considerable
potential in membrane biochemistry. Membr. Biochem. 1:323–327.
Kellosalo, J., Kajander, T., Kogan, K., Pokharel, K., Goldman, A. (2012) The structure and catalytic cycle of a sodiumpumping pyrophosphatase. Science 337:473–476.
Khelashvili, G., LeVine, M.V., Shi, L., Quick, M., Javitch, J.A., Weinstein, H. (2013) The membrane protein LeuT in
micellar systems: Aggregation dynamics and detergent binding to the S2 site. J. Am. Chem. Soc. 135:14266–14275.
Kim, H.M., Howell, S.C., Van Horn, W.D., Jeon, Y.H., Sanders, C.R. (2009) Recent advances in the application of
solution NMR spectroscopy to multi-span integral membrane proteins. Progr. Nucl. Magn. Reson. Spectrosc.
55:335–360.
Király, Z., Börner, R.H.K., Findenegg, G.H. (1997) Adsorption and aggregation of C 8 E 4 and C 8 G 1 nonionic surfactants
on hydrophilic silica studied by calorimetry. Langmuir 13:3308–3315.
Knudsen, P., Hubbell, W.L. (1978) Stability of rhodopsin in detergent solutions. Membr. Biochem. 1:297–322.
Kobilka, B.K., Deupi, X. (2007) Conformational complexity of G-protein-coupled receptors. Trends Pharmacol. Sci.
28:397–406.
Kragh-Hansen, U., le Maire, M., Møller, J.V. (1998) The mechanism of detergent solubilization of liposomes and
protein-containing membranes. Biophys. J. 75:2932–2946.
Kurisu, G., Zhang, H., Smith, J.L., Cramer, W.A. (2003) Structure of the cytochrome b 6 f complex of oxygenic
photosynthesis: tuning the cavity. Science 302:1009–1014.
Lanyi, J.K., Schobert, B. (2007) Structural changes in the L photointermediate of bacteriorhodopsin. J. Mol. Biol.
365:1379–1392.
Lau, F.W., Nauli, S., Zhou, Y., Bowie, J.U. (1999) Changing single side-chains can greatly enhance the resistance of a
membrane protein to irreversible inactivation. J. Mol. Biol. 290:559–564.
le Maire, M., Champeil, P., Møller, J.V. (2000) Interaction of membrane proteins and lipids with solubilizing detergents.
Biochim. Biophys. Acta 1508:86–111.
Lebon, G., Bennett, K., Jazayeri, A., Tate, C.G. (2011a) Thermostabilisation of an agonist-bound conformation of the
human adenosine A 2A receptor. J. Mol. Biol. 409:298–310.
Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G. (2011b) Agonist-bound
adenosine A 2A receptor structures reveal common features of GPCR activation. Nature 474:521–525.
Lee, A.G. (2011a) Biological membranes: the importance of molecular detail. Trends Biochem. Sci. 36:493–500.
Lee, A.G. (2011b) Lipid-protein interactions. Biochem. Soc. Trans. 39:761–766.
Lee, S., Bhattacharya, S., Tate, C.G., Grisshammer, R., Vaidehi, N. (2015) Structural dynamics and thermostabilization
of neurotensin receptor 1. J. Phys. Chem. B 119:4917–4928.
Lee, S., Mao, A., Bhattacharya, S., Robertson, N., Grisshammer, R., Tate, C.G., Vaidehi, N. (2016) How do short chain
nonionic detergents destabilize G protein-coupled receptors? J. Am. Chem. Soc. 138:15425–15433.
Lee, S.C., Bennett, B.C., Hong, W.-X., Fua, Y., Baker, K.A., Marcoux, J., Robinson, C.V., Ward, A.B., Halpert, J.R.,
Stevens, R.C., Stout, C.D., Yeager, M.J., Zhang, Q. (2013) Steroid-based facial amphiphiles for stabilization and
crystallization of membrane proteins. Proc. Natl. Acad. Sci. USA 110:E1203–E1211.
Li, H., Cocco, M.J., Steitz, T.A., Engelman, D.M. (2001) Conversion of phospholamban into a soluble pentameric helix
bundle. Biochemistry 40:6636–6645.
Liao, J., Li, H., Zeng, W., Sauer, D.B., Belmares, R., Jiang, Y. (2012) Structural insight into the ion-exchange
mechanism of the sodium/calcium exchanger. Science 335:686–690.
Lichtenberg, D., Ahyayauch, H., Goñi, F.M. (2013) The mechanism of detergent solubilization of lipid bilayers. Biophys.
J. 105:289–299.
Luecke, H., Schobert, B., Richter, H.-T., Cartailler, J.-P., Lanyi, J.K. (1999) Structure of bacteriorhodopsin at 1.55 Å
resolution. J. Mol. Biol. 291:899–911.
Lund, S., Orlowski, S., de Foresta, B., Champeil, P., le Maire, M., Møller, J.V. (1989) Detergent structure and associated
lipid as determinants in the stabilization of solubilized Ca
2+ -ATPase from sarcoplasmic reticulum. J. Biol. Chem.
264:4907–4915.
References
91