it is attached to the membrane surface by electrostatic interaction. Another is integral
protein which is defined as protein solubilized by detergent such as SDS because it is
bound within the membrane by hydrophobic interaction. These types of membrane
proteins are included in lipid bilayer membranes which spontaneously assemble in
aqueous environment (Fig. 4.2).
Fluid mosaic membrane model
(1972)
Theory of Lipid assembly
Differential scanning calorimetry
Diffusion of histocompatibility antigen
X-ray diffraction
Freeze-fractured electron microscope
Membrane fusion
Inner layer of membrane
Spin labeling(ESR)
Order parameter
Flip-flop
Outer layer of membrane
m
X
m
RT
m
m
mic
m
mic
ln
,
0
,
+
= μ
μ
3
2
1
0 0
10
30
O
O
I
F
F
50
70
°C
ΔCp
4
8
t
Å
-1 x 10
2
Fig. 4.1 Back ground study for fluid mosaic membrane model
Fig. 4.2 Scheme of biomembrane
Biomembrane is composed of lipid bilayer and two types of proteins such as integral protein and
peripheral protein
60
4 Structure and Physical Properties of Biomembranes
protein which is defined as protein solubilized by detergent such as SDS because it is
bound within the membrane by hydrophobic interaction. These types of membrane
proteins are included in lipid bilayer membranes which spontaneously assemble in
aqueous environment (Fig. 4.2).
Fluid mosaic membrane model
(1972)
Theory of Lipid assembly
Differential scanning calorimetry
Diffusion of histocompatibility antigen
X-ray diffraction
Freeze-fractured electron microscope
Membrane fusion
Inner layer of membrane
Spin labeling(ESR)
Order parameter
Flip-flop
Outer layer of membrane
m
X
m
RT
m
m
mic
m
mic
ln
,
0
,
+
= μ
μ
3
2
1
0 0
10
30
O
O
I
F
F
50
70
°C
ΔCp
4
8
t
Å
-1 x 10
2
Fig. 4.1 Back ground study for fluid mosaic membrane model
Fig. 4.2 Scheme of biomembrane
Biomembrane is composed of lipid bilayer and two types of proteins such as integral protein and
peripheral protein
60
4 Structure and Physical Properties of Biomembranes