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53. Bosi S, Da Ros T, Spalluto G et al (2003) Fullerene derivatives: an attractive tool for
biological applications. Eur J Med Chem 38:913–923
54. Marchesan S, Da Ros T, Spalluto G et al (2005) Anti-HIV properties of cationic fullerene
derivatives. Bioorg Med Chem Lett 15:3615–3618
55. Chabre YM, Roy R (2011) Solving promiscuous protein carbohydrate recognition domains
with multivalent glycofullerenes. In: Renaudet O, Spinelli N (eds) Synthesis and biological
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56. Wennekes T, van den Berg RJBHN, Bonger KM et al (2010) Synthesis and evaluation of
dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism. Tetrahedron
Asymmetry 20:836–846
57. Lohse A, Jensen KB, Lundgren K, Bols M (1999) Synthesis and deconvolution of the first
combinatorial library of glycosidase inhibitors. Bioorg Med Chem 7:1965–1971
58. Compain P, Decroocq C, Iehl J et al (2010) Glycosidase inhibition with fullerene iminosugar
balls: a dramatic multivalent effect. Angew Chem Int Ed Engl 49:5753–5756
59. Diot J, Garcia-Moreno MI, Gouin SG et al (2009) Multivalent iminosugars to modulate
affinity and selectivity for glycosidases. Org Biomol Chem 7:357–363
60. Durka M, Buffet K, Iehl J et al (2012) The inhibition of liposaccharide heptosyltransferase
WaaC with multivalent glycosylated fullerenes: a new mode of glycosyltransferase inhibition. Chem Eur J 18:641–651
61. Escaich S (2008) Antivirulence as a new antibacterial approach for chemotherapy. Curr Opin
Chem Biol 12:400–408
62. Moreau F, Desroy N, Genevard JM et al (2008) Discovery of new Gram-negative
antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors. Bioorg Med
Chem Lett 18:4022–4026
63. Tasis D, Tagmatarchis N, Bianco A et al (2006) Chemistry of carbon nanotubes. Chem Rev
106:1105–1136
64. Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery.
Curr Opin Chem Biol 9:674–679
65. Martin CR, Kohli P (2003) The emerging field of nanotube biotechnology. Nat Rev Drug
Discov 2:29–37
66. Lin Y, Taylor S, Li H et al (2004) Advances toward bioapplications of carbon nanotubes.
J Mater Chem 5:27–541
67. Prato M, Kostarelos K, Bianco A (2008) Functionalized carbon nanotubes in drug design and
discovery. Acc Chem Res 41:60–68
68. Pastorin G, Kostarelos K, Prato M et al (2005) Functionalized carbon nanotubes: towards the
delivery of therapeutic molecules. J Biomed Nanotechnol 1:133–142
69. Pantarotto D, Singh R, McCarthy D et al (2004) Functionalized carbon nanotubes for plasmid
DNA gene delivery. Angew Chem Int Ed 43:5242–5246
70. Shi Kam NW, Jessop TC, Wender PA et al (2004) Nanotube molecular transporters:
internalization of carbon nanotube-protein conjugates into mammalian cells. J Am Chem
Soc 126:6850–6851
71. Bianco A, Kostarelos K, Partidos CD et al (2005) Biomedical applications of functionalised
carbon nanotubes. Chem Commun 2005:571–577
72. Gorityala BK, Ma J, Wang X (2010) Carbohydrate functionalized carbon nanotubes and their
applications. Chem Soc Rev 39:2925–2934
73. Bandaru NM, Voelcker NH (2012) Glycoconjugate-functionalized carbon nanotubes in
biomedicine. J Mater Chem 22:8748–8758
338
N. Kottari et al.
5136–5190
51. Jensen AW, Wilson SR, Schuster DI (1996) Biological applications of fullerenes.
Bioorg Med Chem 4:767–779
52. Da Ros T, Prato M (1999) Medicinal chemistry with fullerenes and fullerene derivatives.
Chem Commun 1999:663–669
53. Bosi S, Da Ros T, Spalluto G et al (2003) Fullerene derivatives: an attractive tool for
biological applications. Eur J Med Chem 38:913–923
54. Marchesan S, Da Ros T, Spalluto G et al (2005) Anti-HIV properties of cationic fullerene
derivatives. Bioorg Med Chem Lett 15:3615–3618
55. Chabre YM, Roy R (2011) Solving promiscuous protein carbohydrate recognition domains
with multivalent glycofullerenes. In: Renaudet O, Spinelli N (eds) Synthesis and biological
applications of glycoconjugates. Bentham Science, Oak Park, pp. 64–77
56. Wennekes T, van den Berg RJBHN, Bonger KM et al (2010) Synthesis and evaluation of
dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism. Tetrahedron
Asymmetry 20:836–846
57. Lohse A, Jensen KB, Lundgren K, Bols M (1999) Synthesis and deconvolution of the first
combinatorial library of glycosidase inhibitors. Bioorg Med Chem 7:1965–1971
58. Compain P, Decroocq C, Iehl J et al (2010) Glycosidase inhibition with fullerene iminosugar
balls: a dramatic multivalent effect. Angew Chem Int Ed Engl 49:5753–5756
59. Diot J, Garcia-Moreno MI, Gouin SG et al (2009) Multivalent iminosugars to modulate
affinity and selectivity for glycosidases. Org Biomol Chem 7:357–363
60. Durka M, Buffet K, Iehl J et al (2012) The inhibition of liposaccharide heptosyltransferase
WaaC with multivalent glycosylated fullerenes: a new mode of glycosyltransferase inhibition. Chem Eur J 18:641–651
61. Escaich S (2008) Antivirulence as a new antibacterial approach for chemotherapy. Curr Opin
Chem Biol 12:400–408
62. Moreau F, Desroy N, Genevard JM et al (2008) Discovery of new Gram-negative
antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors. Bioorg Med
Chem Lett 18:4022–4026
63. Tasis D, Tagmatarchis N, Bianco A et al (2006) Chemistry of carbon nanotubes. Chem Rev
106:1105–1136
64. Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery.
Curr Opin Chem Biol 9:674–679
65. Martin CR, Kohli P (2003) The emerging field of nanotube biotechnology. Nat Rev Drug
Discov 2:29–37
66. Lin Y, Taylor S, Li H et al (2004) Advances toward bioapplications of carbon nanotubes.
J Mater Chem 5:27–541
67. Prato M, Kostarelos K, Bianco A (2008) Functionalized carbon nanotubes in drug design and
discovery. Acc Chem Res 41:60–68
68. Pastorin G, Kostarelos K, Prato M et al (2005) Functionalized carbon nanotubes: towards the
delivery of therapeutic molecules. J Biomed Nanotechnol 1:133–142
69. Pantarotto D, Singh R, McCarthy D et al (2004) Functionalized carbon nanotubes for plasmid
DNA gene delivery. Angew Chem Int Ed 43:5242–5246
70. Shi Kam NW, Jessop TC, Wender PA et al (2004) Nanotube molecular transporters:
internalization of carbon nanotube-protein conjugates into mammalian cells. J Am Chem
Soc 126:6850–6851
71. Bianco A, Kostarelos K, Partidos CD et al (2005) Biomedical applications of functionalised
carbon nanotubes. Chem Commun 2005:571–577
72. Gorityala BK, Ma J, Wang X (2010) Carbohydrate functionalized carbon nanotubes and their
applications. Chem Soc Rev 39:2925–2934
73. Bandaru NM, Voelcker NH (2012) Glycoconjugate-functionalized carbon nanotubes in
biomedicine. J Mater Chem 22:8748–8758
338
N. Kottari et al.