conjugation of Annexin A2 and resulted in an efficient target therapy of curcumin to
Annexin-A2-positive MDA-MB-231 cancer cells [125]. Curcumin-PLGA NPs
stabilized with PEG-5000 exhibited enhanced cellular uptake and increased bioactivity in vitro using KBM-5 (human chronic myeloid leukemia), Jurkat (human T cell
leukemia), DU145 (prostate carcinoma), MDA-MB-231 (breast adenocarcinoma),
Fig. 3 (a) Curcumin-PLGA nanospheres in water and (b) free curcumin in water. (c) TEM image
of curcumin-PLGA nanospheres. (d) Confocal microscopy scan illustrating the encapsulation and
distribution of curcumin (green fluorescence) within the PLGA nanospheres. (e) Confocal images
of different cell lines incubated with curcumin-PLGA nanospheres: cell nuclei stained with DAPI,
cells showing curcumin in PLGA nanospheres, and merged images of DAPI and curcumin in
PLGA nanospheres [123]
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Annexin-A2-positive MDA-MB-231 cancer cells [125]. Curcumin-PLGA NPs
stabilized with PEG-5000 exhibited enhanced cellular uptake and increased bioactivity in vitro using KBM-5 (human chronic myeloid leukemia), Jurkat (human T cell
leukemia), DU145 (prostate carcinoma), MDA-MB-231 (breast adenocarcinoma),
Fig. 3 (a) Curcumin-PLGA nanospheres in water and (b) free curcumin in water. (c) TEM image
of curcumin-PLGA nanospheres. (d) Confocal microscopy scan illustrating the encapsulation and
distribution of curcumin (green fluorescence) within the PLGA nanospheres. (e) Confocal images
of different cell lines incubated with curcumin-PLGA nanospheres: cell nuclei stained with DAPI,
cells showing curcumin in PLGA nanospheres, and merged images of DAPI and curcumin in
PLGA nanospheres [123]
Phytomedicine-Loaded Polymeric Nanomedicines: Potential Cancer Therapeutics
217