145. Espuelas MS, Legrand P, Loiseau PM et al (2002) In vitro antileishmanial activity of
amphotericin B loaded in poly (epsilon-caprolactone) nanospheres. J Drug Target
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146. Yordanov G, Abrashev N, Dushkin C (2010) Poly(n-butylcyanoacrylate) submicron particles
loaded with ciprofloxacin for potential treatment of bacterial infections. Prog Colloid Polym
Sci 137:53–59
147. Yordanov R, Skrobanska A, Evangelatov A (2012) Entrapment of epirubicin in poly (butyl
cyanoacrylate) colloidal nanospheres by nanoprecipitation: formulation development and
in vitro studies on cancer cell lines. Colloids Surf B Biointerfaces 92:98–105
148. Balland O, Pinto-Alphandary H, Pecquet S et al (1994) The uptake of ampicillin-loaded
nanoparticles by murine macrophages infected with Salmonella typhimurium. J Antimicrob
Chemother 33:509–522
149. Briones E, Colino CI, Lanao JM (2008) Delivery systems to increase the selectivity of
antibiotics in phagocytic cells. J Control Release 125:210–227
150. Forestier F, Gerrier P, Chaumard C et al (1992) Effect of nanoparticle-bound ampicillin on
the survival of Listeria monocytogenes in mouse peritoneal macrophages. J Antimicrob
Chemother 30:173–179
151. Nishioka Y, Yoshino H (2001) Lymphatic targeting with nanoparticulate system. Adv Drug
Deliv Rev 47:55–64
152. Gulyaev AE, Gelperina SE, Skidan IN et al (1999) Significant transport of doxorubicin into
the brain with polysorbate 80-coated nanoparticles. Pharm Res 16:1564–1569
153. Ramge P, Unger RE, Oltrogge J et al (2000) Polysorbate-80 coating enhances uptake of
polybutylcyanoacrylate (PBCE)-nanoparticles by human and bovine primary brain capillary
endothelial cells. Eur J Neurosci 12:1931–1940
154. Gursoy A, Eroglu L, Ulutin S et al (1989) Evaluation of indomethacin nanocapsules for their
physical stability and inhibitory activity on inflammation and platelet aggregation. Int J
Pharm 52:101–108
155. Abraham DJ (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs:
alginate and chitosan. J Control Release 114:1–14
156. Baruch L, Machluf M (2006) Alginate-chitosan complex coacervation for cell encapsulation:
effect on mechanical properties and on long-term viability. Biopolymers 82:570–579
157. Nordtveit RJ, Varum KM, Smidstrod O (1996) Degradation of partially N-acetylated
chitosans with hen egg white and human lysozyme. Carbohydr Polym 29:163–167
158. Shi C, Zhu Y, Ran X et al (2006) Therapeutic potential of chitosan and its derivatives in
regenerative medicine. J Surg Res 133:185–192
159. Martinac A, Filipovi J, Voinovich D et al (2005) Development and bioadhesive properties of
chitosan-ethylcellulose microspheres for nasal delivery. Int J Pharm 291:69–77
160. Illum L, Jabbal-Gill I, Hinchcliffe M et al (2001) Chitosan as a novel nasal delivery system
for vaccines. Adv Drug Deliv Rev 51:81–96
161. Onishi H, Takahashi H, Yoshiyasu M et al (2001) Preparation and in vitro properties of
N-Succinylchitosan or carboxymethylchitin-mitomycin C conjugate microparticles with
specified size. Drug Dev Ind Pharm 27:659–667
162. De Campos AM, Sanchez A, Alonso MJ (2001) Chitosan nanoparticles: a new vehicle for the
improvement of the delivery of drugs to the ocular surface, Application to cyclosporin A. Int J
Pharm 224:159–168
163. Wu Y, Yang W, Wang C et al (2005) Chitosan nanoparticles as a novel delivery system for
ammonium glycyrrhizinate. Int J Pharm 295:235–245
164. Yamamoto M, Ikada Y, Tabata Y (2001) Controlled release of growth factors based on
biodegradation of gelatin hydrogel. J Biomater Sci Polym Ed 12:77–88
165. Balakrishnan B, Jayakrishnan A (2005) Self-cross-linking biopolymers as injectable in situ
forming biodegradable scaffolds. Biomaterials 26:3941–3951
166. Yao CH, Liu BS, Hsu SH et al (2004) Biocompatibility and biodegradation of a bone
composite containing tricalcium phosphate and genipin crosslinked gelatin. J Biomed
Mater Res 69A:709–717
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
201
amphotericin B loaded in poly (epsilon-caprolactone) nanospheres. J Drug Target
10:593–599
146. Yordanov G, Abrashev N, Dushkin C (2010) Poly(n-butylcyanoacrylate) submicron particles
loaded with ciprofloxacin for potential treatment of bacterial infections. Prog Colloid Polym
Sci 137:53–59
147. Yordanov R, Skrobanska A, Evangelatov A (2012) Entrapment of epirubicin in poly (butyl
cyanoacrylate) colloidal nanospheres by nanoprecipitation: formulation development and
in vitro studies on cancer cell lines. Colloids Surf B Biointerfaces 92:98–105
148. Balland O, Pinto-Alphandary H, Pecquet S et al (1994) The uptake of ampicillin-loaded
nanoparticles by murine macrophages infected with Salmonella typhimurium. J Antimicrob
Chemother 33:509–522
149. Briones E, Colino CI, Lanao JM (2008) Delivery systems to increase the selectivity of
antibiotics in phagocytic cells. J Control Release 125:210–227
150. Forestier F, Gerrier P, Chaumard C et al (1992) Effect of nanoparticle-bound ampicillin on
the survival of Listeria monocytogenes in mouse peritoneal macrophages. J Antimicrob
Chemother 30:173–179
151. Nishioka Y, Yoshino H (2001) Lymphatic targeting with nanoparticulate system. Adv Drug
Deliv Rev 47:55–64
152. Gulyaev AE, Gelperina SE, Skidan IN et al (1999) Significant transport of doxorubicin into
the brain with polysorbate 80-coated nanoparticles. Pharm Res 16:1564–1569
153. Ramge P, Unger RE, Oltrogge J et al (2000) Polysorbate-80 coating enhances uptake of
polybutylcyanoacrylate (PBCE)-nanoparticles by human and bovine primary brain capillary
endothelial cells. Eur J Neurosci 12:1931–1940
154. Gursoy A, Eroglu L, Ulutin S et al (1989) Evaluation of indomethacin nanocapsules for their
physical stability and inhibitory activity on inflammation and platelet aggregation. Int J
Pharm 52:101–108
155. Abraham DJ (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs:
alginate and chitosan. J Control Release 114:1–14
156. Baruch L, Machluf M (2006) Alginate-chitosan complex coacervation for cell encapsulation:
effect on mechanical properties and on long-term viability. Biopolymers 82:570–579
157. Nordtveit RJ, Varum KM, Smidstrod O (1996) Degradation of partially N-acetylated
chitosans with hen egg white and human lysozyme. Carbohydr Polym 29:163–167
158. Shi C, Zhu Y, Ran X et al (2006) Therapeutic potential of chitosan and its derivatives in
regenerative medicine. J Surg Res 133:185–192
159. Martinac A, Filipovi J, Voinovich D et al (2005) Development and bioadhesive properties of
chitosan-ethylcellulose microspheres for nasal delivery. Int J Pharm 291:69–77
160. Illum L, Jabbal-Gill I, Hinchcliffe M et al (2001) Chitosan as a novel nasal delivery system
for vaccines. Adv Drug Deliv Rev 51:81–96
161. Onishi H, Takahashi H, Yoshiyasu M et al (2001) Preparation and in vitro properties of
N-Succinylchitosan or carboxymethylchitin-mitomycin C conjugate microparticles with
specified size. Drug Dev Ind Pharm 27:659–667
162. De Campos AM, Sanchez A, Alonso MJ (2001) Chitosan nanoparticles: a new vehicle for the
improvement of the delivery of drugs to the ocular surface, Application to cyclosporin A. Int J
Pharm 224:159–168
163. Wu Y, Yang W, Wang C et al (2005) Chitosan nanoparticles as a novel delivery system for
ammonium glycyrrhizinate. Int J Pharm 295:235–245
164. Yamamoto M, Ikada Y, Tabata Y (2001) Controlled release of growth factors based on
biodegradation of gelatin hydrogel. J Biomater Sci Polym Ed 12:77–88
165. Balakrishnan B, Jayakrishnan A (2005) Self-cross-linking biopolymers as injectable in situ
forming biodegradable scaffolds. Biomaterials 26:3941–3951
166. Yao CH, Liu BS, Hsu SH et al (2004) Biocompatibility and biodegradation of a bone
composite containing tricalcium phosphate and genipin crosslinked gelatin. J Biomed
Mater Res 69A:709–717
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
201