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235. Teijeiro-Osorio D, Remunan-Lopez C, Alonso MJ (2009) New generation of hybrid
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Biomacromolecules 10:243–249
236. Liu ZG, Jiao YP, Liu F et al (2007) Heparin/chitosan nanoparticle carriers prepared by
polyelectrolyte complexation. J Biomed Mater Res A 83A:806–812
237. Dai H, Jiang X, Tan GCY et al (2006) Chitosan-DNA nanoparticles delivered by intrabiliary
infusion enhance liver-targeted gene delivery. Int J Nanomedicine 1:507–522
238. Zhang H, Oh M, Allen C et al (2004) Monodosperse chitosan nanoparticles for mucosal drug
delivery. Biomacromolecules 5:2461–2468
239. Hrictu D, Popa MI, Popa N et al (2009) Preparation and characterization of magnetic chitosan
nanospheres. Turk J Chem 33:785–796
240. Kievit FM, Veiseh O, Bhattarai N et al (2009) PEI-PEG-Chitosan copolymer coated ironoxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection. Adv
Funct Mater 19:2244–2251
241. Tan YL, Liu CG (2011) Preparation and characterization of self-assemblied nanoparticles
based on folic acid modified carboxymethyl chitosan. J Mater Sci Mater Med 22:1213–1220
242. Kavya KC, Dixit R, Jayakumar R et al (2012) Synthesis and characterization of chitosan/
chondroitin sulfate/nano-SiO 2 composite scaffold for bone tissue engineering. J Biomed
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Engineering of Polysaccharides via Nanotechnology
133
221. Hasegawa U, Nomura SM, Kaul SC et al (2005) Nanogel-quantum dot hybrid nanoparticles
for live cell imaging. Biochem Biophys Res Commun 331:917–921
222. Tan WB, Jiang S, Zhang Y (2007) Quantum-dot based nanoparticles for targeted silencing of
HER2/neu gene via RNA interference. Biomaterials 28:165–1571
223. Bhang SH, Won N, Lee T et al (2009) Hyaluronic acid-quantum dot conjugates for in vivo
lymphatic vessel imaging. ACS Nano 3:1389–1398
224. Wu W, Shen J, Banerjee P et al (2010) Chitosan-based responsive hybrid nanogels for
integration of optical pH-sensing, tumor cell imaging and controlled drug delivery.
Biomaterials 31:8371–8381
225. Liu Z, Jiao Y, Wang Y et al (2008) Polysaccharides-based nanoparticles as drug delivery
systems. Adv Drug Deliv Rev 60:1650–1652
226. Agnihotri SA, Mallakarjuna NN, Aminabhavi TM (2004) Recent advances on chitosan-based
micro- and nanoparticle in drug delivery. J Control Release 100:5–28
227. Nanjawade BK, Manvi FV, Manjappa AS (2007) In-situ forming hydrogels for sustained
ophthalmic drug delivery. J Control Release 122:119–134
228. Sundar S, Kundu J, Kundu SC (2010) Biopolymeric nanoparticles. Sci Technol Adv Mater
11:014104–014114
229. Li L, Chen D, Zhang Y et al (2007) Magnetic and fluorescent multifunctional chitosan
nanoparticles as a smart drug delivery systems. Nanotechnology 18:405102. doi:10.1088/
0957-4484/18/40/405102
230. Wilson B, Samanta MK, Santhi K et al (2010) Chitosan nanoparticles as a new delivery
system for the anti-alzheimer drug tarcine. Nanomedicine 6:144–152
231. Nagpal K, Singh SK, Mishra DN (2010) Chitosan nanoparticles: a promising system in novel
drug delivery. Chem Pharm Bull (Tokyo) 58:1423–1430
232. Chauddhury A, Das S (2011) Recent advancement of chitosan-based nanoparticels for oral
controlled delivery of insulin and other therapeutic agents. AAPS PharmSciTech 12:10–20
233. Tang DW, Yu SH, Ho YC et al (2010) Heparinized chitosan/poly (γ-glutamic acid)
nanoparticles for multi-functional delivery of fibroblast growth factor and heparin.
Biomaterials 31:9320–9332
234. Sarmento B, Rebeiro A, Veiga F et al (2007) Oral bioavailability of insulin contained in
polysaccharide nanoparticles. Biomacromolecules 8:3054–3060
235. Teijeiro-Osorio D, Remunan-Lopez C, Alonso MJ (2009) New generation of hybrid
polyoligosaccharide nanoparticels as carriers for the nasal delivery of macromolecules.
Biomacromolecules 10:243–249
236. Liu ZG, Jiao YP, Liu F et al (2007) Heparin/chitosan nanoparticle carriers prepared by
polyelectrolyte complexation. J Biomed Mater Res A 83A:806–812
237. Dai H, Jiang X, Tan GCY et al (2006) Chitosan-DNA nanoparticles delivered by intrabiliary
infusion enhance liver-targeted gene delivery. Int J Nanomedicine 1:507–522
238. Zhang H, Oh M, Allen C et al (2004) Monodosperse chitosan nanoparticles for mucosal drug
delivery. Biomacromolecules 5:2461–2468
239. Hrictu D, Popa MI, Popa N et al (2009) Preparation and characterization of magnetic chitosan
nanospheres. Turk J Chem 33:785–796
240. Kievit FM, Veiseh O, Bhattarai N et al (2009) PEI-PEG-Chitosan copolymer coated ironoxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection. Adv
Funct Mater 19:2244–2251
241. Tan YL, Liu CG (2011) Preparation and characterization of self-assemblied nanoparticles
based on folic acid modified carboxymethyl chitosan. J Mater Sci Mater Med 22:1213–1220
242. Kavya KC, Dixit R, Jayakumar R et al (2012) Synthesis and characterization of chitosan/
chondroitin sulfate/nano-SiO 2 composite scaffold for bone tissue engineering. J Biomed
Nanotechnol 8:149–160
Engineering of Polysaccharides via Nanotechnology
133