Table 9 Chitosan-based nanomaterials and their biomedical applications
Chitosan-based
nanomaterial
Method of preparation
Application
Reference
Chitosan-g-PEG
nanoparticles
Ionic gelation and self-assembly Protein delivery
[113]
Heparinized chitosan/
poly(γ-glutamic
acid) nanoparticles
Self-assembly
Multifunctional
delivery of
fibroblast growth
factor and heparin
[233]
Chitosan–dextran
sulfate nanoparticles
Self-assembly
Insulin delivery to
protect protein in an
oral delivery
application
[234]
Chitosan–cyclodextrin
nanoparticles
–
To facilitate nasal drug
delivery
[235]
Chitosan–heparin
polyelectrolyte
complex
nanoparticles
–
Protein delivery
[236]
Chitosan–DNA
nanoparticles
–
Liver-targeted gene
delivery
[237]
Monodisperse chitosan
nanoparticles
–
Mucosal delivery
[238]
Folate-conjugated
pluronic F127/
chitosan core–shell
nanoparticles
Self-assembly
Breast cancer treatment [135]
N-Succinyl chitosan
nanospheres
Self-assembly
Sustained drug delivery
system
[163]
Magnetic chitosan
nanospheres
Co-precipitation followed by
ionic gelation
Bioseparation
[239]
PEI-PEG-chitosan
copolymer-coated
iron-oxide
nanoparticles
Chemical co-precipitation
Gene delivery
[240]
Folic acid-modified
carboxymethyl
chitosan
nanoparticles
Sonication
Drug carrier for tumorspecific drug
delivery
[241]
Chitosan/chondroitin
sulfate/nano-SiO 2
composite scaffold
Lyophilization
Bone tissue engineering [242]
Chitosan-coated ZnS
and Zns:Mn
2+
quantum dots
Radiation technology
Low cytotoxicity and
high
biocompatibility
mean that they
could be useful for
further biomedical
application
[243]
(continued)
Engineering of Polysaccharides via Nanotechnology
121