of progressing pre-clinical drug candidates to market (http://www.starpharma.com/
news/157).
In research and teaching we have to realize that progress in science does not only
happen via linear planned research or through the continuous collection of facts. In
addition we need “revolutionary” processes, which induce the replacement of
existing models of explanation (paradigms) by new concepts: A paradigm shift! It
was Thomas S. Kuhn who first discussed this in his book The structure of scientific
revolutions [24]. When talking about the importance of unexpected results, the
notion “serendipity” is often used, especially in the medical field. This is based on
an old oriental fairy tale of the three princes – maybe young scientists – of Serendip
(Sri Lanka): On their journeys, with luck and courage they always discover new,
unexpected things.
4.3 The Joy of Discovery: On the Way! Just a Few Articles
and Reviews in the Field of Polymer Therapeutics
To mark the tenth anniversary of Nature Reviews Drug Discovery, the journal brought
together analyses data and trends in the field [22]; some of them are cited here:
– Patent watch: Key patent-related events of the past 10 years [25]
– How were new medicines discovered? [26]
– Membrane transporters in drug development [27]
– Knocking down barriers in siRNA delivery [28]
– Angiogenesis: an organizing principle for drug discovery [29]
– Recent advances with liposomes as pharmaceutical carrier [30]
In the following list are some more papers from different “research desks”:
– Polymeric micelles [31, 32]
– Enhanced permeability and retention effect [33, 34]
– Endocytosis and intracellular trafficking [35, 36]
– Polymer therapeutics: the end of the beginning [37]
– Nanomedicine(s) under the microscope, history and status (containing about
500 key references) [38]
– Preclinical safety and regularity implication for design and development of
polymer therapeutics [39]
– The physics of cancer [40]
– Liposomal antitumor vaccines [41]
– Polymer-based antitumour vaccines [42]
– Natural Product and Material Chemistries – separated forever? [43]
A Moment of Reflection: Sixty Years After the Nobel Prize for Hermann Staudinger
17
news/157).
In research and teaching we have to realize that progress in science does not only
happen via linear planned research or through the continuous collection of facts. In
addition we need “revolutionary” processes, which induce the replacement of
existing models of explanation (paradigms) by new concepts: A paradigm shift! It
was Thomas S. Kuhn who first discussed this in his book The structure of scientific
revolutions [24]. When talking about the importance of unexpected results, the
notion “serendipity” is often used, especially in the medical field. This is based on
an old oriental fairy tale of the three princes – maybe young scientists – of Serendip
(Sri Lanka): On their journeys, with luck and courage they always discover new,
unexpected things.
4.3 The Joy of Discovery: On the Way! Just a Few Articles
and Reviews in the Field of Polymer Therapeutics
To mark the tenth anniversary of Nature Reviews Drug Discovery, the journal brought
together analyses data and trends in the field [22]; some of them are cited here:
– Patent watch: Key patent-related events of the past 10 years [25]
– How were new medicines discovered? [26]
– Membrane transporters in drug development [27]
– Knocking down barriers in siRNA delivery [28]
– Angiogenesis: an organizing principle for drug discovery [29]
– Recent advances with liposomes as pharmaceutical carrier [30]
In the following list are some more papers from different “research desks”:
– Polymeric micelles [31, 32]
– Enhanced permeability and retention effect [33, 34]
– Endocytosis and intracellular trafficking [35, 36]
– Polymer therapeutics: the end of the beginning [37]
– Nanomedicine(s) under the microscope, history and status (containing about
500 key references) [38]
– Preclinical safety and regularity implication for design and development of
polymer therapeutics [39]
– The physics of cancer [40]
– Liposomal antitumor vaccines [41]
– Polymer-based antitumour vaccines [42]
– Natural Product and Material Chemistries – separated forever? [43]
A Moment of Reflection: Sixty Years After the Nobel Prize for Hermann Staudinger
17