48. Itaka K, Kanayama N, Nishiyama N, Jang WD, Yamasaki Y, Nakamura K, Kawaguchi H,
Kataoka K (2004) Supramolecular nanocarrier of siRNA from PEG-based block catiomer
carrying diamine side chain with distinctive pKa directed to enhance intracellular gene
silencing. J Am Chem Soc 126(13):612–613
49. Yokoyama M, Okano T, Sakurai Y, Suwa S, Kataoka K (1996) Introduction of cisplatin into
polymeric micelle. J Contr Release 39:351–356
50. Nishiyama N, Okazaki S, Cabral H, Miyamoto M, Kato Y, Sugiyama Y, Nishio K,
Matsumura Y, Kataoka K (2003) Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res 63:8977–8983
51. Cabral H, Nishiyama N, Okazaki S, Koyama H, Kataoka K (2005) Preparation and biological
properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric
micelles. J Contr Release 101:223–232
52. Kataoka K, Ishihara A, Harada A, Miyazaki H (1998) Effect of the secondary structure of poly
(L-lysine) segments on the micellization in aqueous milieu of poly(ethylene glycol)–poly
(L-lysine) block copolymer partially substituted with a hydrocinnamoyl group at the
N-epsilon-position. Macromolecules 31:6071–6076
53. Kakizawa Y, Kataoka K (2002) Block copolymer self-assembly into monodispersive
nanoparticles with hybrid core of antisense DNA and calcium phosphate. Langmuir 18:
4539–4543
54. Osada K, Yamasaki Y, Katayose S, Kataoka K (2005) A synthetic block copolymer regulates
S1 nuclease fragmentation of supercoiled plasmid DNA. Angew Chem Int Ed 44:3544–3548
55. Osada K, Oshima H, Kobayashi D, Doi M, Enoki M, Yamasaki Y, Kataoka K (2010)
Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod
structures promoting transgene efficacy. J Am Chem Soc 132:12343–12348
56. Burkoth TS, Benzinger TLS, Urban V, Lynn DG, Meredith SC, Thiyagarajan P (1999) Selfassembly of Aβ (10–35) -PEG block copolymer fibrils. J Am Chem Soc 121:7429–7430
57. Checler F (1995) Processing of the β-amyloid precursor protein and its regulation in
alzheimer’s disease. J Neurochemistry 65:1431–1444
58. Lynn DG, Meredith SC (2000) Review: model peptides and the physicochemical approach to
β-amyloids. J Struc Biol 130:153–173
59. Zhang L, Eisenberg A (1995) Multiple morphologies of "crew-cut" aggregates of polystyreneb-poly(acrylic acid) block copolymers. Science 268:1728–1731
60. Koide A, Kishimura A, Osada K, Jang W-D, Yamasaki Y, Kataoka K (2006) Semipermeable
polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely
charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble
macromolecules. J Am Chem Soc 128:5988–5989
61. Osada K, Cabral H, Mochida Y, Lee S, Nagata K, Matsuura T, Yamamoto M, Anraku Y,
Kishimura A, Nishiyama N, Kataoka K (2012) Bioactive polymeric metallosomes selfassembled through block copolymerÀmetal complexation. J Am Chem Soc 134:13172–13175
62. Arifin DR, Palmer AF (2005) Polymersome encapsulated hemoglobin: a novel type of oxygen
carrier. Biomacromol 6:2172–2181
63. Kishimura A, Koide A, Osada K, Yamasaki Y, Kataoka K (2007) Encapsulation of myoglobin
in PEGylated polyion complex vesicles made from a pair of oppositely charged block
ionomers: a physiologically available oxygen carrier. Angew Chem Int Ed 46:6085–6088
64. vanDongen SFM, Verdurmen WPR, Peters RJRW, Nolte RJM, Brock R, van Hest JCM (2010)
Cellular integration of an enzyme-loaded polymersome nanoreactor. Angew Chem Int Ed
49:7213–7216
65. Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE (2007) Shape effects of
filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2:249–255
66. Aida T, Meijer EW, Stupp SI (2012) Functional supramolecular polymers. Science 335:
813–817
67. Lutolf MP, Hubbell JF (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23:47–55
Bridging Polymer Science and Medicine Through Supramolecular Nanoassemblies
261
Kataoka K (2004) Supramolecular nanocarrier of siRNA from PEG-based block catiomer
carrying diamine side chain with distinctive pKa directed to enhance intracellular gene
silencing. J Am Chem Soc 126(13):612–613
49. Yokoyama M, Okano T, Sakurai Y, Suwa S, Kataoka K (1996) Introduction of cisplatin into
polymeric micelle. J Contr Release 39:351–356
50. Nishiyama N, Okazaki S, Cabral H, Miyamoto M, Kato Y, Sugiyama Y, Nishio K,
Matsumura Y, Kataoka K (2003) Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res 63:8977–8983
51. Cabral H, Nishiyama N, Okazaki S, Koyama H, Kataoka K (2005) Preparation and biological
properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric
micelles. J Contr Release 101:223–232
52. Kataoka K, Ishihara A, Harada A, Miyazaki H (1998) Effect of the secondary structure of poly
(L-lysine) segments on the micellization in aqueous milieu of poly(ethylene glycol)–poly
(L-lysine) block copolymer partially substituted with a hydrocinnamoyl group at the
N-epsilon-position. Macromolecules 31:6071–6076
53. Kakizawa Y, Kataoka K (2002) Block copolymer self-assembly into monodispersive
nanoparticles with hybrid core of antisense DNA and calcium phosphate. Langmuir 18:
4539–4543
54. Osada K, Yamasaki Y, Katayose S, Kataoka K (2005) A synthetic block copolymer regulates
S1 nuclease fragmentation of supercoiled plasmid DNA. Angew Chem Int Ed 44:3544–3548
55. Osada K, Oshima H, Kobayashi D, Doi M, Enoki M, Yamasaki Y, Kataoka K (2010)
Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod
structures promoting transgene efficacy. J Am Chem Soc 132:12343–12348
56. Burkoth TS, Benzinger TLS, Urban V, Lynn DG, Meredith SC, Thiyagarajan P (1999) Selfassembly of Aβ (10–35) -PEG block copolymer fibrils. J Am Chem Soc 121:7429–7430
57. Checler F (1995) Processing of the β-amyloid precursor protein and its regulation in
alzheimer’s disease. J Neurochemistry 65:1431–1444
58. Lynn DG, Meredith SC (2000) Review: model peptides and the physicochemical approach to
β-amyloids. J Struc Biol 130:153–173
59. Zhang L, Eisenberg A (1995) Multiple morphologies of "crew-cut" aggregates of polystyreneb-poly(acrylic acid) block copolymers. Science 268:1728–1731
60. Koide A, Kishimura A, Osada K, Jang W-D, Yamasaki Y, Kataoka K (2006) Semipermeable
polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely
charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble
macromolecules. J Am Chem Soc 128:5988–5989
61. Osada K, Cabral H, Mochida Y, Lee S, Nagata K, Matsuura T, Yamamoto M, Anraku Y,
Kishimura A, Nishiyama N, Kataoka K (2012) Bioactive polymeric metallosomes selfassembled through block copolymerÀmetal complexation. J Am Chem Soc 134:13172–13175
62. Arifin DR, Palmer AF (2005) Polymersome encapsulated hemoglobin: a novel type of oxygen
carrier. Biomacromol 6:2172–2181
63. Kishimura A, Koide A, Osada K, Yamasaki Y, Kataoka K (2007) Encapsulation of myoglobin
in PEGylated polyion complex vesicles made from a pair of oppositely charged block
ionomers: a physiologically available oxygen carrier. Angew Chem Int Ed 46:6085–6088
64. vanDongen SFM, Verdurmen WPR, Peters RJRW, Nolte RJM, Brock R, van Hest JCM (2010)
Cellular integration of an enzyme-loaded polymersome nanoreactor. Angew Chem Int Ed
49:7213–7216
65. Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE (2007) Shape effects of
filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2:249–255
66. Aida T, Meijer EW, Stupp SI (2012) Functional supramolecular polymers. Science 335:
813–817
67. Lutolf MP, Hubbell JF (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23:47–55
Bridging Polymer Science and Medicine Through Supramolecular Nanoassemblies
261