7. Jenkins LB, Kredel FE, Mccord WM (1956) Evaluation of polyvinyl pyrrolidone as a plasma
expander. AMA Arch Surg 72:612–617
8. Regelson W, Holand JF (1958) The anionic polyelectrolyte polyethylenesulfonate, as a new
anti-neoplastic agent. Nature 181:46–47
9. Breslow DS (1976) Biologically active synthetic polymers. Pure Appl Chem 46:103–113
10. Regelson W, Holand JF (1962) Clinical pharmacology of a macromolecule. Clin Pharmacol
Ther 3:730–749
11. Ringsdorf H (1975) Structure and properties of pharmacologically active polymers. J Polym
Sci Symp 51:135–153
12. de Duve C, de Barsy T, Poole B, Trouet A, Tulkens P, Van Hoof F (1974) Lysosomotropic
agents. Biochem Pharmacol 23:2495–2531
13. Strebhardt K, Ullrich A (2008) Paul Ehrlich’s magic bullet concept: 100 years of progress.
Nat Rev Cancer 8:473–480
14. Duncan R, Kopec ˇek J (1984) Soluble synthetic-polymers as potential drug carriers. Adv Polym
Sci 57:51–101
15. Duncan R, Cable HC, Lloyd JB, Rejmanova P, Kopec ˇek J (1983) Polymers containing
enzymatically degradable bonds 7: design of oligopeptide side-chains in poly
[n-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by
lysosomal-enzymes. Makromol Chem Macromol Chem Phys 184:1997–2008
16. Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS,
Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J (1999) Phase I clinical and
pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]:
first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Clin Cancer
Res 5:83–94
17. Maeda H, Takeshita J, Kanamaru R (1979) A lipophilic derivative of neocarzinostatin a
polymer conjugation of an antitumor protein antibiotic. Int J Pept Protein Res 14:81–87
18. Maeda H (1991) SMANCS and polymer-conjugated macromolecular drugs: advantages in
cancer chemotherapy. Adv Drug Deliv Rev 46:169–185
19. Matsumura Y, Maeda H (1986) A new concept for macromolecular therapeutics in cancer
chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent
SMANCS. Cancer Res 46:6387–6392
20. Davis FF (2002) The origin of PEGnology. Adv Drug Del Rev 54:457–458
21. Abuchowski A, van Es T, Palczuk NC, Davis FF (1977) Alteration of immunological properties
of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem
252:3578–3581
22. Abuchowski A, McCoy JR, Palczuk NC, van Es T, Davis FF (1977) Effect of covalent
attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver
catalase. J Biol Chem 252:3582–3586
23. Klibanov A, Maruyama K, Torchilin VP, Huang L (1990) Amphipathic polyethyleneglycols
effectively prolong the circulation time of liposomes. FEBS Lett 268:235–237
24. Woodle MC, Lasic DD, Redemann C (1991) Sterically stabilized liposomes: improvements in
pharmacokinetics and anti-tumor therapeutic efficacy. Proc Natl Acad Sci USA 88:
11460–11464
25. Philp D, Stoddart JF (1996) Self-Assembly in natural and unnatural systems. Angew Chem Int
Ed Engl 35:1154–1196
26. Bader H, Ringsdorf H, Schmidt B (1984) Watersoluble polymers in medicine. Angew
Makromol Chem 123:457–485
27. Kabanov AV, Chekhonin VP, Alakhov V, Batrakova EV, Lebedev AS, Melik-Nubarov NS,
Arzhakov SA, Levashov AV, Morozov GV, Severin ES (1989) The neuroleptic activity of
haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers
for drug targeting. FEBS Lett 258:343–345
Bridging Polymer Science and Medicine Through Supramolecular Nanoassemblies
259
expander. AMA Arch Surg 72:612–617
8. Regelson W, Holand JF (1958) The anionic polyelectrolyte polyethylenesulfonate, as a new
anti-neoplastic agent. Nature 181:46–47
9. Breslow DS (1976) Biologically active synthetic polymers. Pure Appl Chem 46:103–113
10. Regelson W, Holand JF (1962) Clinical pharmacology of a macromolecule. Clin Pharmacol
Ther 3:730–749
11. Ringsdorf H (1975) Structure and properties of pharmacologically active polymers. J Polym
Sci Symp 51:135–153
12. de Duve C, de Barsy T, Poole B, Trouet A, Tulkens P, Van Hoof F (1974) Lysosomotropic
agents. Biochem Pharmacol 23:2495–2531
13. Strebhardt K, Ullrich A (2008) Paul Ehrlich’s magic bullet concept: 100 years of progress.
Nat Rev Cancer 8:473–480
14. Duncan R, Kopec ˇek J (1984) Soluble synthetic-polymers as potential drug carriers. Adv Polym
Sci 57:51–101
15. Duncan R, Cable HC, Lloyd JB, Rejmanova P, Kopec ˇek J (1983) Polymers containing
enzymatically degradable bonds 7: design of oligopeptide side-chains in poly
[n-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by
lysosomal-enzymes. Makromol Chem Macromol Chem Phys 184:1997–2008
16. Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS,
Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J (1999) Phase I clinical and
pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]:
first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Clin Cancer
Res 5:83–94
17. Maeda H, Takeshita J, Kanamaru R (1979) A lipophilic derivative of neocarzinostatin a
polymer conjugation of an antitumor protein antibiotic. Int J Pept Protein Res 14:81–87
18. Maeda H (1991) SMANCS and polymer-conjugated macromolecular drugs: advantages in
cancer chemotherapy. Adv Drug Deliv Rev 46:169–185
19. Matsumura Y, Maeda H (1986) A new concept for macromolecular therapeutics in cancer
chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent
SMANCS. Cancer Res 46:6387–6392
20. Davis FF (2002) The origin of PEGnology. Adv Drug Del Rev 54:457–458
21. Abuchowski A, van Es T, Palczuk NC, Davis FF (1977) Alteration of immunological properties
of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem
252:3578–3581
22. Abuchowski A, McCoy JR, Palczuk NC, van Es T, Davis FF (1977) Effect of covalent
attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver
catalase. J Biol Chem 252:3582–3586
23. Klibanov A, Maruyama K, Torchilin VP, Huang L (1990) Amphipathic polyethyleneglycols
effectively prolong the circulation time of liposomes. FEBS Lett 268:235–237
24. Woodle MC, Lasic DD, Redemann C (1991) Sterically stabilized liposomes: improvements in
pharmacokinetics and anti-tumor therapeutic efficacy. Proc Natl Acad Sci USA 88:
11460–11464
25. Philp D, Stoddart JF (1996) Self-Assembly in natural and unnatural systems. Angew Chem Int
Ed Engl 35:1154–1196
26. Bader H, Ringsdorf H, Schmidt B (1984) Watersoluble polymers in medicine. Angew
Makromol Chem 123:457–485
27. Kabanov AV, Chekhonin VP, Alakhov V, Batrakova EV, Lebedev AS, Melik-Nubarov NS,
Arzhakov SA, Levashov AV, Morozov GV, Severin ES (1989) The neuroleptic activity of
haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers
for drug targeting. FEBS Lett 258:343–345
Bridging Polymer Science and Medicine Through Supramolecular Nanoassemblies
259