136. Tan ML, Friedhuber AM, Dunstan E et al (2010) The performance of doxorubicin
encapsulated in chitosan–dextran sulphate microparticles in an osteosarcoma model.
Biomaterials 31(3):541–551
137. Lu E, Franzblau S, Onyuksel H et al (2009) Preparation of aminoglycosideloaded chitosan
nanoparticles using dextran sulphate as a counterion. J Microencaps 26(4):346–354
138. Costa E, Sapag-Hagar J, Valenzuela F et al (2004) Comparative studies on polyelectrolyte
complexes and mixtures of chitosan–alginate and chitosan–carrageenan as prolonged diltiazem clorhydrate release systems. Eur J Pharm Biopharm 57:65–75
139. Tiwari A, Bindal S, Bohidar HB (2009) Kinetics of protein-protein complex coacervation and
biphasic release of salbutamol sulfate from coacervate matrix. Biomacromolecules
10:184–189
140. Hong C, Caihua N, Liping Z (2012) Preparation of complex nano-particles based on alginic
acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release
controlled by ionic strength. Eur J Pharm Sci 45(1–2):43–49
141. Lee KY, Park WH, Ha WS (1997) Polyelectrolyte complexes of sodium alginate with
chitosan or its derivatives for microcapsules. J Appl Polymer Sci 63:425–432
142. Coppi G, Iannuccelli V (2009) Alginate/chitosan microparticles for tamoxifen delivery to the
lymphatic system. Int J Pharm 367:127–132
143. Thiele C, Auerbach D, Jung G et al (2011) Nanoparticles of anionic starch and cationic
cyclodextrin derivatives for the targeted delivery of drugs. Polym Chem 2:209–215
144. Yuan J, Luo Y, Gao Q (2011) Self-assembled polyion complex micelles for sustained release
of hydrophilic drug. J Microencaps 28(2):93–98
145. Chuang CY, Chiu WY, Don TM (2011) Synthesis of chitosan-poly(acrylic acid) complex
particles by dispersion polymerization and their applications in ph buffering and drug release.
J Appl Polym Sci 120(3):1659–1670
146. Lei G, Yanfeng M, Guiying L et al (2011) Self-assembled nanoparticles from thermosensitive polyion complex micelles for controlled drug release. Chem Eng J 174(1):199–205
147. M€ uller M (2011) Method for producing a drug delivery system on the basis of polyelectrolyte
complexes. Patent publication DE 10 2010 003 615 A1 and WO 2011/121019 A2
148. Chung AJ, Rubner MF (2002) Methods of loading and releasing low molecular weight
cationic molecules in weak polyelectrolyte multilayer films. Langmuir 18:1176–1183
149. M€ uller M, Keßler B (2012) Release of pamidronate from poly(ethyleneimine)/cellulose
sulphate complex nanoparticle films: An in-situ ATR-FTIR study. J Pharm Biomed Anal
66:183–190
150. Rogers MJ, Crockett JC, Coxon FP et al (2011) Biochemical and molecular mechanisms of
action of bisphosphonates. Bone 49:34–41
151. Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet
377:1276–1287
152. M€ uller M, Rieser T, Lunkwitz K et al (1998) An in-situ ATR-FTIR study on polyelectrolyte
multilayer assemblies on solid surfaces and their susceptibility to fouling. Macromol Rapid
Commun 19(7):333–336
153. Keller TF, M€ uller M, Ouyang W et al (2010) Templating alpha-helical poly(L-lysine)/
polyanion complexes by nanostructured uniaxially oriented ultrathin polyethylene films.
Langmuir 26(24):18893–18901
154. M€ uller M, Keßler B (2011) Deposition from dopamine solutions at Ge substrates: an in situ
ATR-FTIR study. Langmuir 27(20):12499–12505
155. Ouyang W, M€ uller M, Appelhans D, Voit B (2009) In situ ATR-FTIR investigation on the
preparation and enantiospecificity of chiral polyelectrolyte multilayers. ACS Appl Mater
Interfaces 1(12):2878–2885
156. M€ uller M, Grosse I, Jacobasch HJ, Sams P (1998) Surfactant adsorption and water desorption
on thin cellulose films monitored by in-situ ATR FTIR spectroscopy. Tenside Surfactants
Detergents 35(5):354
258
M. M€ uller
encapsulated in chitosan–dextran sulphate microparticles in an osteosarcoma model.
Biomaterials 31(3):541–551
137. Lu E, Franzblau S, Onyuksel H et al (2009) Preparation of aminoglycosideloaded chitosan
nanoparticles using dextran sulphate as a counterion. J Microencaps 26(4):346–354
138. Costa E, Sapag-Hagar J, Valenzuela F et al (2004) Comparative studies on polyelectrolyte
complexes and mixtures of chitosan–alginate and chitosan–carrageenan as prolonged diltiazem clorhydrate release systems. Eur J Pharm Biopharm 57:65–75
139. Tiwari A, Bindal S, Bohidar HB (2009) Kinetics of protein-protein complex coacervation and
biphasic release of salbutamol sulfate from coacervate matrix. Biomacromolecules
10:184–189
140. Hong C, Caihua N, Liping Z (2012) Preparation of complex nano-particles based on alginic
acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release
controlled by ionic strength. Eur J Pharm Sci 45(1–2):43–49
141. Lee KY, Park WH, Ha WS (1997) Polyelectrolyte complexes of sodium alginate with
chitosan or its derivatives for microcapsules. J Appl Polymer Sci 63:425–432
142. Coppi G, Iannuccelli V (2009) Alginate/chitosan microparticles for tamoxifen delivery to the
lymphatic system. Int J Pharm 367:127–132
143. Thiele C, Auerbach D, Jung G et al (2011) Nanoparticles of anionic starch and cationic
cyclodextrin derivatives for the targeted delivery of drugs. Polym Chem 2:209–215
144. Yuan J, Luo Y, Gao Q (2011) Self-assembled polyion complex micelles for sustained release
of hydrophilic drug. J Microencaps 28(2):93–98
145. Chuang CY, Chiu WY, Don TM (2011) Synthesis of chitosan-poly(acrylic acid) complex
particles by dispersion polymerization and their applications in ph buffering and drug release.
J Appl Polym Sci 120(3):1659–1670
146. Lei G, Yanfeng M, Guiying L et al (2011) Self-assembled nanoparticles from thermosensitive polyion complex micelles for controlled drug release. Chem Eng J 174(1):199–205
147. M€ uller M (2011) Method for producing a drug delivery system on the basis of polyelectrolyte
complexes. Patent publication DE 10 2010 003 615 A1 and WO 2011/121019 A2
148. Chung AJ, Rubner MF (2002) Methods of loading and releasing low molecular weight
cationic molecules in weak polyelectrolyte multilayer films. Langmuir 18:1176–1183
149. M€ uller M, Keßler B (2012) Release of pamidronate from poly(ethyleneimine)/cellulose
sulphate complex nanoparticle films: An in-situ ATR-FTIR study. J Pharm Biomed Anal
66:183–190
150. Rogers MJ, Crockett JC, Coxon FP et al (2011) Biochemical and molecular mechanisms of
action of bisphosphonates. Bone 49:34–41
151. Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet
377:1276–1287
152. M€ uller M, Rieser T, Lunkwitz K et al (1998) An in-situ ATR-FTIR study on polyelectrolyte
multilayer assemblies on solid surfaces and their susceptibility to fouling. Macromol Rapid
Commun 19(7):333–336
153. Keller TF, M€ uller M, Ouyang W et al (2010) Templating alpha-helical poly(L-lysine)/
polyanion complexes by nanostructured uniaxially oriented ultrathin polyethylene films.
Langmuir 26(24):18893–18901
154. M€ uller M, Keßler B (2011) Deposition from dopamine solutions at Ge substrates: an in situ
ATR-FTIR study. Langmuir 27(20):12499–12505
155. Ouyang W, M€ uller M, Appelhans D, Voit B (2009) In situ ATR-FTIR investigation on the
preparation and enantiospecificity of chiral polyelectrolyte multilayers. ACS Appl Mater
Interfaces 1(12):2878–2885
156. M€ uller M, Grosse I, Jacobasch HJ, Sams P (1998) Surfactant adsorption and water desorption
on thin cellulose films monitored by in-situ ATR FTIR spectroscopy. Tenside Surfactants
Detergents 35(5):354
258
M. M€ uller