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92. Stone AL, Epstein P (1977) The aggregation of basic polypeptide residues bound to heparin.
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93. Bystricky S, Malovlikova A, Sticzay T (1991) Interaction of acidic polysaccharides with
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94. Bystricky S, Malovlikova A, Sticzay T (1990) Interaction of alginates and pectins with
cationic polypeptides. Carbohydr Polym 13:283–294
95. Sapay N, Cabannes E, Petitou M, Imberty A (2011) Molecular modeling of the interaction
between heparin sulfate and cellular growth factors: bringing pieces together. Glycobiology
21(9):1181–1193
96. Pichert A, Samsonov SA, Theisgen S et al (2012) Characterization of the interaction of
interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated
derivatives by spectroscopy and molecular modelling. Glycobiology 22(1):134–145
97. Greenfield N, Fasman GD (1969) Computed circular dichroism spectra for the evaluation of
protein conformation. Biochemistry 8(10):4108–4116
98. M€ uller M, Ouyang W, Bohata K et al (2010) Nanostructured complexes of polyelectrolytes
and charged polypeptides. Adv Biomaterials 12(9):519–528
99. Zhengzhan D, Jingbo Y, Shifeng Y et al (2007) Polyelectrolyte complexes based on chitosan
and poly(L-glutamic acid). Polymer Int 56(9):1122–1127
100. Decher G (1997) Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science
277(5330):1232–1237
101. Narambuena CF, Leiva EPM, Cha ´vez-Pa ´ez M et al (2010) Effect of chain stiffness on the
morphology of polyelectrolyte complexes. A Monte Carlo simulation study. Polymer
51:3293–3302
102. Kunze KK, Netz RR (2002) Morphologies of semiflexible polyelectrolyte complexes.
Europhys Lett 58(2):299–305
103. Maurstad G, Danielsen S, Stokke BT (2003) Analysis of compacted semiflexible polyanions
visualized by atomic force microscopy: influence of chain stiffness on the morphologies of
polyelectrolyte complexes. J Phys Chem B 107:8172–8180
104. Schnurr B, Gittes F, MacKintosh FC (2002) Metastable intermediates in the condensation of
semiflexible polymers. Phys Rev E 65:061904
105. Duncan R, Gaspar R (2011) Nanomedicine(s) under the microscope. Mol Pharm 8:2101–2141
106. Cruz T, Gaspar R, Donato A, Lopes C (1997) Interaction between polyalkylcyanoacrylate
nanoparticles and peritoneal macrophages: MTT metabolism, NBT reduction, and NO
production. Pharm Res 14(1):73–79
107. Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic
applications. Nat Rev Drug Discov 9:615–627
108. Panyam P, Labhasetwar V (2003) Biodegradable nanoparticles for drug and gene delivery to
cells and tissue. Adv Drug Deliv Rev 55:329–347
109. Debuigne F, Cuisenaire J, Jeunieau L et al (2001) Synthesis of nimesulide nanoparticles in the
microemulsion epikuron/isopropyl myristate/water/n-butanol (or isopropanol). J Colloid
Interface Sci 243:90–101
110. Chern CS, Lee CK, Chang CJ (2004) Electrostatic interactions between amphoteric latex
particles and proteins. Colloid Polym Sci 283:257–264
111. Fatouros DG, Piperoudi S, Gortzi O et al (2005) Physical stability of sonicated
arsonoliposomes: effect of calcium ions. J Pharm Sci 94:46–55
112. Shiraishi S, Imai T, Otagiri M (1993) Controlled release of indomethacin by chitosanpolyelectrolyte complex: optimization and in viva/in vitro evaluation. J Control Release
25:217–225
113. Champion JA, Mitragotri S (2006) Role of target geometry in phagocytosis. Proc Natl Acad
Sci USA 103:4930–4934
256
M. M€ uller
poly-L-lysine in aqueous solution: circular dichroism studies. Biopolymers 12:541–558
92. Stone AL, Epstein P (1977) The aggregation of basic polypeptide residues bound to heparin.
Biochim Biophys Acta 497:298–306
93. Bystricky S, Malovlikova A, Sticzay T (1991) Interaction of acidic polysaccharides with
polylysine enantiomers. Conformation probe in solution. Carbohyd Polym 15:299–308
94. Bystricky S, Malovlikova A, Sticzay T (1990) Interaction of alginates and pectins with
cationic polypeptides. Carbohydr Polym 13:283–294
95. Sapay N, Cabannes E, Petitou M, Imberty A (2011) Molecular modeling of the interaction
between heparin sulfate and cellular growth factors: bringing pieces together. Glycobiology
21(9):1181–1193
96. Pichert A, Samsonov SA, Theisgen S et al (2012) Characterization of the interaction of
interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated
derivatives by spectroscopy and molecular modelling. Glycobiology 22(1):134–145
97. Greenfield N, Fasman GD (1969) Computed circular dichroism spectra for the evaluation of
protein conformation. Biochemistry 8(10):4108–4116
98. M€ uller M, Ouyang W, Bohata K et al (2010) Nanostructured complexes of polyelectrolytes
and charged polypeptides. Adv Biomaterials 12(9):519–528
99. Zhengzhan D, Jingbo Y, Shifeng Y et al (2007) Polyelectrolyte complexes based on chitosan
and poly(L-glutamic acid). Polymer Int 56(9):1122–1127
100. Decher G (1997) Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science
277(5330):1232–1237
101. Narambuena CF, Leiva EPM, Cha ´vez-Pa ´ez M et al (2010) Effect of chain stiffness on the
morphology of polyelectrolyte complexes. A Monte Carlo simulation study. Polymer
51:3293–3302
102. Kunze KK, Netz RR (2002) Morphologies of semiflexible polyelectrolyte complexes.
Europhys Lett 58(2):299–305
103. Maurstad G, Danielsen S, Stokke BT (2003) Analysis of compacted semiflexible polyanions
visualized by atomic force microscopy: influence of chain stiffness on the morphologies of
polyelectrolyte complexes. J Phys Chem B 107:8172–8180
104. Schnurr B, Gittes F, MacKintosh FC (2002) Metastable intermediates in the condensation of
semiflexible polymers. Phys Rev E 65:061904
105. Duncan R, Gaspar R (2011) Nanomedicine(s) under the microscope. Mol Pharm 8:2101–2141
106. Cruz T, Gaspar R, Donato A, Lopes C (1997) Interaction between polyalkylcyanoacrylate
nanoparticles and peritoneal macrophages: MTT metabolism, NBT reduction, and NO
production. Pharm Res 14(1):73–79
107. Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic
applications. Nat Rev Drug Discov 9:615–627
108. Panyam P, Labhasetwar V (2003) Biodegradable nanoparticles for drug and gene delivery to
cells and tissue. Adv Drug Deliv Rev 55:329–347
109. Debuigne F, Cuisenaire J, Jeunieau L et al (2001) Synthesis of nimesulide nanoparticles in the
microemulsion epikuron/isopropyl myristate/water/n-butanol (or isopropanol). J Colloid
Interface Sci 243:90–101
110. Chern CS, Lee CK, Chang CJ (2004) Electrostatic interactions between amphoteric latex
particles and proteins. Colloid Polym Sci 283:257–264
111. Fatouros DG, Piperoudi S, Gortzi O et al (2005) Physical stability of sonicated
arsonoliposomes: effect of calcium ions. J Pharm Sci 94:46–55
112. Shiraishi S, Imai T, Otagiri M (1993) Controlled release of indomethacin by chitosanpolyelectrolyte complex: optimization and in viva/in vitro evaluation. J Control Release
25:217–225
113. Champion JA, Mitragotri S (2006) Role of target geometry in phagocytosis. Proc Natl Acad
Sci USA 103:4930–4934
256
M. M€ uller