234. Ren Y, Jiang X, Pan D, Mao H-Q (2010) Charge density and molecular weight of
polyphosphoramidate gene carrier: are key parameters influencing its DNA compaction
ability and transfection efficiency. Biomacromolecules 11:3432–3439
235. Khan M, Beniah G, Wiradharma N, Guo XD, Yang YY (2010) Brush-like amphoteric poly
[isobutylene-alt-(maleic acid)-graft-oligoethyleneamine)]/DNA complexes for efficient gene
transfection. Macromol Rapid Commun 31:1142–1147
236. Ferruti P, Manzoni S, Richardson SCW, Duncan R, Pattrick NG, Mendichi R, Casolaro M
(2000) Amphoteric linear poly(amido-amine)s as endosomolytic polymers: correlation
between physicochemical and biological properties. Macromolecules 33:7793–7800
237. Franchini J, Ranucci E, Ferruti P, Rossi M, Cavalli R (2006) Synthesis, physicochemical
properties, and preliminary biological characterizations of a novel amphoteric agmatinebased poly(amidoamine) with RGD-like repeating units. Biomacromolecules 7:1215–1222
238. Ferruti P, Franchini J, Bencini M, Ranucci E, Zara GP, Serpe L, Primo L, Cavalli R (2007)
Prevailingly cationic agmatine-based amphoteric polyamidoamine as a nontoxic, nonhemolytic, and “stealthlike” DNA complexing agent and transfection promoter. Biomacromolecules 8:1498–1504
239. Cavalli R, Bisazza A, Sessa R, Primo L, Fenili F, Manfredi A, Ranucci E, Ferruti P (2010)
Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and
in vivo delivery. Biomacromolecules 11:2667–2674
240. Strachan T, Read AP (1999) Human molecular genetics, 2nd edn. Wiley-Liss, New York,
Chap 22
241. Go ¨ssl I, Shu L, Schlu ¨ter D, Rabe JP (2002) Molecular structure of single DNA complexes
with positively charged dendronized polymers. J Am Chem Soc 124:6860–6865
242. Laschewsky A (2012) Recent trends in the synthesis of polyelectrolytes. Curr Opin Colloid
Interface Sci 17:56–63
243. Schlick T, Hayes J, Grigoryev S (2012) Toward convergence of experimental studies and
theoretical modeling of the chromatin fiber. J Biol Chem 287:5183–5191
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
195
polyphosphoramidate gene carrier: are key parameters influencing its DNA compaction
ability and transfection efficiency. Biomacromolecules 11:3432–3439
235. Khan M, Beniah G, Wiradharma N, Guo XD, Yang YY (2010) Brush-like amphoteric poly
[isobutylene-alt-(maleic acid)-graft-oligoethyleneamine)]/DNA complexes for efficient gene
transfection. Macromol Rapid Commun 31:1142–1147
236. Ferruti P, Manzoni S, Richardson SCW, Duncan R, Pattrick NG, Mendichi R, Casolaro M
(2000) Amphoteric linear poly(amido-amine)s as endosomolytic polymers: correlation
between physicochemical and biological properties. Macromolecules 33:7793–7800
237. Franchini J, Ranucci E, Ferruti P, Rossi M, Cavalli R (2006) Synthesis, physicochemical
properties, and preliminary biological characterizations of a novel amphoteric agmatinebased poly(amidoamine) with RGD-like repeating units. Biomacromolecules 7:1215–1222
238. Ferruti P, Franchini J, Bencini M, Ranucci E, Zara GP, Serpe L, Primo L, Cavalli R (2007)
Prevailingly cationic agmatine-based amphoteric polyamidoamine as a nontoxic, nonhemolytic, and “stealthlike” DNA complexing agent and transfection promoter. Biomacromolecules 8:1498–1504
239. Cavalli R, Bisazza A, Sessa R, Primo L, Fenili F, Manfredi A, Ranucci E, Ferruti P (2010)
Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and
in vivo delivery. Biomacromolecules 11:2667–2674
240. Strachan T, Read AP (1999) Human molecular genetics, 2nd edn. Wiley-Liss, New York,
Chap 22
241. Go ¨ssl I, Shu L, Schlu ¨ter D, Rabe JP (2002) Molecular structure of single DNA complexes
with positively charged dendronized polymers. J Am Chem Soc 124:6860–6865
242. Laschewsky A (2012) Recent trends in the synthesis of polyelectrolytes. Curr Opin Colloid
Interface Sci 17:56–63
243. Schlick T, Hayes J, Grigoryev S (2012) Toward convergence of experimental studies and
theoretical modeling of the chromatin fiber. J Biol Chem 287:5183–5191
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
195