6 Macrolactones by Base-Induced Macrolactonization
of Benzodioxinones to Benzolactones
6.1 Background
A related but mechanistically different process to dioxolenone or β-keto ester
thermolysis marks the base-induced macrolactonization of benzodioxinones
to benzolactones (Scheme 25). This method has been independently described
Scheme 23 β-Keto ester thermolysis and subsequent macrolactonization in the total synthesis of
(–)-amphidinolide P, 95
Scheme 24 Intramolecular acylketene capture in the total synthesis of (–)-A26771B, 98
390
M. Cordes and M. Kalesse
of Benzodioxinones to Benzolactones
6.1 Background
A related but mechanistically different process to dioxolenone or β-keto ester
thermolysis marks the base-induced macrolactonization of benzodioxinones
to benzolactones (Scheme 25). This method has been independently described
Scheme 23 β-Keto ester thermolysis and subsequent macrolactonization in the total synthesis of
(–)-amphidinolide P, 95
Scheme 24 Intramolecular acylketene capture in the total synthesis of (–)-A26771B, 98
390
M. Cordes and M. Kalesse