Preface
The use of transition metal catalysis has provided organic chemists with a wide and
quasi-exhaustive toolbox to create selectively the C(sp
2 )-N bonds, essential not
only for the development of bioactive molecules but also for materials engineering.
Drawing on the bountiful number of publications related to this topic in the last
10 years, this volume mainly focuses on the most significant results and important
breakthroughs.
The volume highlights in the first chapter, written by Lemen and Wolfe, the
discovery and the development of original palladium-based catalysts for C(sp
2 )-N
bond formation via the coupling of nitrogen nucleophiles and aryl/alkenyl halides
and pseudohalides. The authors also report various applications of these transformations to the synthesis of useful compounds, including biologically active molecules and materials.
In the second chapter, Correa and Bolm discuss a powerful set of protocols
involving C(sp
2 )-N bond formation which have emerged as reliable and convenient
alternatives for the assembly of enamines and enamides. The authors also describe
palladium-catalyzed oxidative amination of alkenes and both palladium- and
copper-catalyzed cross-couplings generally between vinyl halides or pseudohalides
and amines or amides.
Owing to their importance for pharmaceutical and material sciences,
N-containing heterocycles have received great attention from the synthetic community. Another masterpiece of this volume “Assembly of N-Containing Heterocycles via Pd and Cu-Catalyzed C–N Bond Formation Reactions”, presented by
Jiang and Ma, covers the original and last contributions on the development of Pdand Cu-catalysts for the assembly of N-heterocycles such as indoles, benzimidazoles, pyrroles, indazoles, indolines, lactams, quizolinones, heterobenzazepines,
and other N-containing heterocycles.
By far the greatest number of reports on the modern catalytic Ullmann-type
reactions has dealt with the creation of C–N bonds. Kantam et al. present, in their
chapter, the recent developments in heterogeneous or recyclable copper-catalysts
available to selectively form this C(sp
2 )-N bond. The challenges and opportunities
v
The use of transition metal catalysis has provided organic chemists with a wide and
quasi-exhaustive toolbox to create selectively the C(sp
2 )-N bonds, essential not
only for the development of bioactive molecules but also for materials engineering.
Drawing on the bountiful number of publications related to this topic in the last
10 years, this volume mainly focuses on the most significant results and important
breakthroughs.
The volume highlights in the first chapter, written by Lemen and Wolfe, the
discovery and the development of original palladium-based catalysts for C(sp
2 )-N
bond formation via the coupling of nitrogen nucleophiles and aryl/alkenyl halides
and pseudohalides. The authors also report various applications of these transformations to the synthesis of useful compounds, including biologically active molecules and materials.
In the second chapter, Correa and Bolm discuss a powerful set of protocols
involving C(sp
2 )-N bond formation which have emerged as reliable and convenient
alternatives for the assembly of enamines and enamides. The authors also describe
palladium-catalyzed oxidative amination of alkenes and both palladium- and
copper-catalyzed cross-couplings generally between vinyl halides or pseudohalides
and amines or amides.
Owing to their importance for pharmaceutical and material sciences,
N-containing heterocycles have received great attention from the synthetic community. Another masterpiece of this volume “Assembly of N-Containing Heterocycles via Pd and Cu-Catalyzed C–N Bond Formation Reactions”, presented by
Jiang and Ma, covers the original and last contributions on the development of Pdand Cu-catalysts for the assembly of N-heterocycles such as indoles, benzimidazoles, pyrroles, indazoles, indolines, lactams, quizolinones, heterobenzazepines,
and other N-containing heterocycles.
By far the greatest number of reports on the modern catalytic Ullmann-type
reactions has dealt with the creation of C–N bonds. Kantam et al. present, in their
chapter, the recent developments in heterogeneous or recyclable copper-catalysts
available to selectively form this C(sp
2 )-N bond. The challenges and opportunities
v