Top Organomet Chem (2013) 46: 119–172
DOI: 10.1007/3418_2012_58
# Springer-Verlag Berlin Heidelberg 2013
Published online: 21 March 2013
Recent Developments in Recyclable Copper
Catalyst Systems for C–N Bond Forming
Cross-Coupling Reactions Using Aryl Halides
and Arylboronic Acids
Mannepalli Lakshmi Kantam, Chintareddy Venkat Reddy, Pottabathula
Srinivas, and Suresh Bhargava
Abstract This review covers the recent recyclable protocols for the C–N bond
forming reactions between aromatic, heterocyclic and aliphatic amines such as
imidazoles, benzimidazoles, benzylamines, piperidine, pyrrole, imides, anilines,
hexyl, cyclohexyl amines, and amides as coupling partners with aryl iodides,
bromides, chlorides, and arylboronic acids employing copper-mediated systems.
The physical properties and characterization of the catalysts and their use in organic
synthesis will be outlined. Most importantly, these recyclable versions developed by
many groups in the recent years are potential candidates for commercial exploitation. The effect of additives, solvents, temperature, base, the nature of aryl halides on
reactivity, and recycle studies of the heterogeneous catalysts are included in this
M.L. Kantam (*)
Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology,
Hyderabad 500607, India
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
e-mail: mlakshmi@iict.res.in; lkmannepalli@gmail.com
C. Venkat Reddy
Department of Chemistry, Iowa State University, 1311 Gilman Hall, Ames, IA 50011, USA
e-mail: chvenkatreddy@gmail.com
P. Srinivas
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
S. Bhargava
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
Advanced Materials & Industrial Chemistry, School of Applied Sciences, RMIT University,
GPO Box 2476V, Melbourne, VIC 3001, Australia
e-mail: suresh.bhargava@rmit.edu.au
DOI: 10.1007/3418_2012_58
# Springer-Verlag Berlin Heidelberg 2013
Published online: 21 March 2013
Recent Developments in Recyclable Copper
Catalyst Systems for C–N Bond Forming
Cross-Coupling Reactions Using Aryl Halides
and Arylboronic Acids
Mannepalli Lakshmi Kantam, Chintareddy Venkat Reddy, Pottabathula
Srinivas, and Suresh Bhargava
Abstract This review covers the recent recyclable protocols for the C–N bond
forming reactions between aromatic, heterocyclic and aliphatic amines such as
imidazoles, benzimidazoles, benzylamines, piperidine, pyrrole, imides, anilines,
hexyl, cyclohexyl amines, and amides as coupling partners with aryl iodides,
bromides, chlorides, and arylboronic acids employing copper-mediated systems.
The physical properties and characterization of the catalysts and their use in organic
synthesis will be outlined. Most importantly, these recyclable versions developed by
many groups in the recent years are potential candidates for commercial exploitation. The effect of additives, solvents, temperature, base, the nature of aryl halides on
reactivity, and recycle studies of the heterogeneous catalysts are included in this
M.L. Kantam (*)
Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology,
Hyderabad 500607, India
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
e-mail: mlakshmi@iict.res.in; lkmannepalli@gmail.com
C. Venkat Reddy
Department of Chemistry, Iowa State University, 1311 Gilman Hall, Ames, IA 50011, USA
e-mail: chvenkatreddy@gmail.com
P. Srinivas
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
S. Bhargava
IICT-RMIT Research Centre, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607,
India
Advanced Materials & Industrial Chemistry, School of Applied Sciences, RMIT University,
GPO Box 2476V, Melbourne, VIC 3001, Australia
e-mail: suresh.bhargava@rmit.edu.au