Development of Micellized Antimicrobial
Thiosulfinate: A Contemporary Way
of Drug Stability Enhancement
Souptik Bhattacharya, Deepanjali Gupta, Dwaipayan Sen,
and Chiranjib Bhattacharjee
Abstract Over the past few decades, the development of bacterial resistance of
antibiotics and dose-related toxicity of modern aggressive antibiotics has attracted
attention to the dire need of new antibiotic discovery, which is efficient, cost-effective,
and biocompatible. The ancient Indian medicinal system (Ayurveda) provided
concepts of plant-based pharmacotherapy to treat infectious diseases. Medicinal
plant parts contain numerous types of nutraceutical phytochemicals like flavonoids,
phenols, thiosulfinate, quinones, alkaloids, terpenes, etc., which deliver significant antimicrobial properties and are known to be effective, edible, and nontoxic
drugs. Their mode of action includes DNA inhibition, enzyme inactivation, cell
wall and membrane damage, protein misfolding, denaturation, etc. of microorganisms. Several research works successfully demonstrated that these extracts are very
effective against a wide range of pathogens and multidrug resistant (MDR) bacteria
such as Methicillin-Resistant Staphylococcus aureus (MRSA), uropathogens, Klebsiella, Escherichia, etc. However, low extraction yield and unstable nature of phytochemicals pose major constraints in their commercial utilization. Micellization
using biocompatible surfactants can be employed for enhanced drug delivery and
stability. Naturally derived plant compounds can provide useful and low-cost source
of antimicrobials to mitigate the challenges of drug discovery process required for
antimicrobial chemotherapy.
Keywords Antimicrobial · Ayurveda · Nutraceutical · MDR · Polysorbate
S. Bhattacharya · D. Gupta · C. Bhattacharjee (B)
Department of Chemical Engineering, Jadavpur University, Kolkata, West Bengal 700032, India
e-mail: c.bhatta@gmail.com
S. Bhattacharya
e-mail: souptikjduv@gmail.com
D. Gupta
e-mail: deepanjalig15@gmail.com
D. Sen (B)
Department of Chemical Engineering, Heritage Institute of Technology, Kolkata, West Bengal
700107, India
e-mail: dwaipayanju@gmail.com
© Springer Nature Singapore Pte Ltd. 2021
D. Ramkrishna et al. (eds.), Advances in Bioprocess Engineering and Technology,
Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-7409-2_8
83
Thiosulfinate: A Contemporary Way
of Drug Stability Enhancement
Souptik Bhattacharya, Deepanjali Gupta, Dwaipayan Sen,
and Chiranjib Bhattacharjee
Abstract Over the past few decades, the development of bacterial resistance of
antibiotics and dose-related toxicity of modern aggressive antibiotics has attracted
attention to the dire need of new antibiotic discovery, which is efficient, cost-effective,
and biocompatible. The ancient Indian medicinal system (Ayurveda) provided
concepts of plant-based pharmacotherapy to treat infectious diseases. Medicinal
plant parts contain numerous types of nutraceutical phytochemicals like flavonoids,
phenols, thiosulfinate, quinones, alkaloids, terpenes, etc., which deliver significant antimicrobial properties and are known to be effective, edible, and nontoxic
drugs. Their mode of action includes DNA inhibition, enzyme inactivation, cell
wall and membrane damage, protein misfolding, denaturation, etc. of microorganisms. Several research works successfully demonstrated that these extracts are very
effective against a wide range of pathogens and multidrug resistant (MDR) bacteria
such as Methicillin-Resistant Staphylococcus aureus (MRSA), uropathogens, Klebsiella, Escherichia, etc. However, low extraction yield and unstable nature of phytochemicals pose major constraints in their commercial utilization. Micellization
using biocompatible surfactants can be employed for enhanced drug delivery and
stability. Naturally derived plant compounds can provide useful and low-cost source
of antimicrobials to mitigate the challenges of drug discovery process required for
antimicrobial chemotherapy.
Keywords Antimicrobial · Ayurveda · Nutraceutical · MDR · Polysorbate
S. Bhattacharya · D. Gupta · C. Bhattacharjee (B)
Department of Chemical Engineering, Jadavpur University, Kolkata, West Bengal 700032, India
e-mail: c.bhatta@gmail.com
S. Bhattacharya
e-mail: souptikjduv@gmail.com
D. Gupta
e-mail: deepanjalig15@gmail.com
D. Sen (B)
Department of Chemical Engineering, Heritage Institute of Technology, Kolkata, West Bengal
700107, India
e-mail: dwaipayanju@gmail.com
© Springer Nature Singapore Pte Ltd. 2021
D. Ramkrishna et al. (eds.), Advances in Bioprocess Engineering and Technology,
Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-7409-2_8
83