Modern Advancement of Nanotechnology Over Conventional …
499
capability, thus proving CNO to be an ideal imaging and drug-targeting vehicle
(Camisasca and Giordani 2017).
5 Combinational Therapy
It has been evidenced that multiple-drug treatment is more efficient than single-drug
treatment. It is predicted that when multiple drugs are administered in an optimized
ratio, they show a synergistic effect on the cancer cells. They not only enhance drug
targeting, but also prolong circulation time and reduce drug resistance in cancer
cells. Recent advancements in this field have developed various nanocarriers for
co-delivery of anticancer drugs (Pemovska et al. 2018). Thus, using a theranostic
approach of combining both diagnosing and treating cancer is an emerging platform
through which not only the drug released can be studied, but also its effects on the
cancerous cells are visualized. These abilities can be potentially exploited to develop
personalized medicines (Ahmed et al. 2012).
6 Conclusion
Since several factors affect the biodistribution and targeting, it is difficult to choose
an appropriate nanocarrier based on a few existing comparative studies. To evaluate
the ideal properties of nanocarriers, further studies need to be done based on various
screening methodologies. Utilizing specific nanocarrier or targeting molecule for
improved therapeutic outcomes and reduced costs may be available to the oncologists.
Though we are far from Nobel Laureate Paul Ehrlich’s ‘magic bullet’, it is possible
to believe in an era of nanocarrier-based therapeutics and diagnostics.
References
Ahmed N, Fessi H, Elaissari A (2012) Theranostic applications of nanoparticles in cancer. Drug
Discov Today 17:928–934
Aljabali AAA (2018) Viral nanoparticles: a drug delivery platform. J Drugs Ecotoxicol 1
Aminabad NS, Farshbaf M, Akbarzadeh A (2019) Recent advances of gold nanoparticles in
biomedical applications: state of the art. Cell Biochem Biophys 77:123–137
Anitha P, Bhargavi J, Sravani G et al (2018) Recent progress of dendrimers in drug delivery for
cancer therapy. Int J Appl Pharm 10:34
Aziz ZABA, Ahmad A, Mohd-Setapar SH et al (2017) Recent advances in drug delivery of polymeric
nano-micelles. Curr Drug Metab 18:16–29
Burdus , el A-C, Gherasim O, Grumezescu AM et al (2018) Biomedical applications of silver
nanoparticles: an up-to-date overview. Nanomaterials 8:681
Camisasca A, Giordani S (2017) Carbon nano-onions in biomedical applications: promising
theranostic agents. Inorganica Chim Acta 468:67–76
499
capability, thus proving CNO to be an ideal imaging and drug-targeting vehicle
(Camisasca and Giordani 2017).
5 Combinational Therapy
It has been evidenced that multiple-drug treatment is more efficient than single-drug
treatment. It is predicted that when multiple drugs are administered in an optimized
ratio, they show a synergistic effect on the cancer cells. They not only enhance drug
targeting, but also prolong circulation time and reduce drug resistance in cancer
cells. Recent advancements in this field have developed various nanocarriers for
co-delivery of anticancer drugs (Pemovska et al. 2018). Thus, using a theranostic
approach of combining both diagnosing and treating cancer is an emerging platform
through which not only the drug released can be studied, but also its effects on the
cancerous cells are visualized. These abilities can be potentially exploited to develop
personalized medicines (Ahmed et al. 2012).
6 Conclusion
Since several factors affect the biodistribution and targeting, it is difficult to choose
an appropriate nanocarrier based on a few existing comparative studies. To evaluate
the ideal properties of nanocarriers, further studies need to be done based on various
screening methodologies. Utilizing specific nanocarrier or targeting molecule for
improved therapeutic outcomes and reduced costs may be available to the oncologists.
Though we are far from Nobel Laureate Paul Ehrlich’s ‘magic bullet’, it is possible
to believe in an era of nanocarrier-based therapeutics and diagnostics.
References
Ahmed N, Fessi H, Elaissari A (2012) Theranostic applications of nanoparticles in cancer. Drug
Discov Today 17:928–934
Aljabali AAA (2018) Viral nanoparticles: a drug delivery platform. J Drugs Ecotoxicol 1
Aminabad NS, Farshbaf M, Akbarzadeh A (2019) Recent advances of gold nanoparticles in
biomedical applications: state of the art. Cell Biochem Biophys 77:123–137
Anitha P, Bhargavi J, Sravani G et al (2018) Recent progress of dendrimers in drug delivery for
cancer therapy. Int J Appl Pharm 10:34
Aziz ZABA, Ahmad A, Mohd-Setapar SH et al (2017) Recent advances in drug delivery of polymeric
nano-micelles. Curr Drug Metab 18:16–29
Burdus , el A-C, Gherasim O, Grumezescu AM et al (2018) Biomedical applications of silver
nanoparticles: an up-to-date overview. Nanomaterials 8:681
Camisasca A, Giordani S (2017) Carbon nano-onions in biomedical applications: promising
theranostic agents. Inorganica Chim Acta 468:67–76