Wound Healing and Antimicrobial Property of Phytofabricated …
483
4 Conclusion
It can be concluded that silver nanoparticles that are prepared by S. asoca bark extract
have the ability to heal burn wounds faster than the other synthetic drugs. It also has
good antibacterial activity. Due to insignificant toxicity level, the green nanoparticle
is eco-friendly and helpful for diabetic wound healing.
Acknowledgements The authors gratefully acknowledge the University of Kalyani for financial
support for the research.
References
Al-Shmgani HS, Mohammed WH, Sulaiman GM, Saadoon AH (2017) Biosynthesis of silver
nanoparticles from Catharanthus roseus leaf extract and assessing their antioxidant, antimicrobial
and wound healing activities. Artif Cells Nanomed Biotechnol 45:1234–1240
Banerjee P, Nath D (2015) A phytochemical approach to synthesize silver nanoparticles for nontoxic biomedical page 2 of 14 application and study on their antibacterial efficacy. Nanosci
Technol 2(1):1–14
Bhagavathy S, Kancharla S (2016) Wound healing and angiogenesis of silver nanoparticle from
Azadirachta indica in diabetes induced mice. IJHM 4(5):24–29
Boyum A (1976) Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 5:9–15
Chaloupka K et al (2010) Nanosilver as a new generation of nanoproduct in biomedical applications.
Trends Biotechnol 28:580–588
Dissemond J, Goos M, Wagner SN (2002) The role of oxidative stress in the pathogenesis and
therapy of chronic wounds. Hautarzt 53:718–723
Garg S, Chandra A, Mazumder A, Mazumder R (2014) Green synthesis of silver nanoparticles using
Arnebia nobilis root extract and wound healing potential of its hydrogel. J Pharmac 8(2):95–101
Goia DV (2004) Preparation and formation mechanisms of uniform metallic particles in homogeneous solutions. J Mater Chem 14:451–458
Griffith M et al (2015) Anti-microbiological and anti-infective activities of silver. In: Alarcon EI
(eds) Silver nanoparticle applications: in the fabrication and design of medical and biosensing
devices. Springer, Berlin, pp 127–146
Gunasekaran T, Nigusse T, Dhanaraju MD (2011) Silver nanoparticles as real topical bullets for
wound healing. J Am Col Clin Wound Spec Spec 3:82–96
Mohanta YK, Biswas K, Panda SK, Bandhyopadhyay J, De D, Jayabalan R, Bastia AK, Mohanta
TK (2017) Phyto-assisted synthesis of biofunctionalised silver nanoparticles and their potential
anti-oxidant, anti-microbial, and wound healing activities. IET Nanobiotechnol 11:1027–1034
Mollick MMR, Bhowmick B, Mondal D, Maity D, Rana D, Dash SK, Chattopadhyay S, Roy
S, Sarkar J, Acharya K, Chakraborty M, Chattopadhyay D (2014) Anticancer (in vitro) and
antimicrobial effect of gold nanoparticles synthesized using Abelmoschus esculentus (L.) pulp
extract via a green route. RSC Adv 4:37838–37848
Ovais M, Ayaz M, Khalil AT, Shah SA, Jan MS, Raza A, Shahid M, Shinwari ZK (2018) HPLCDAD finger printing, antioxidant, cholinesterase and α glucosidase inhibitory potentials of a novel
plant Olax nana. BMC Complement Altem Med 18(1):1
Pannerselvam B, Dhamalingam Jothinathan MK, Rajenderan M, Perumal P, Pudupalayam
Thangavelu K, Kim HJ, Singh V, Rangarajulu SK (2017) An in vitro study on the burn wound
healing activity of cotton fabrics incorporated with phytosyntheiszed silver nanoparticles in male
Wister albino rats. Eur J Pharm Sci 100:187–196
483
4 Conclusion
It can be concluded that silver nanoparticles that are prepared by S. asoca bark extract
have the ability to heal burn wounds faster than the other synthetic drugs. It also has
good antibacterial activity. Due to insignificant toxicity level, the green nanoparticle
is eco-friendly and helpful for diabetic wound healing.
Acknowledgements The authors gratefully acknowledge the University of Kalyani for financial
support for the research.
References
Al-Shmgani HS, Mohammed WH, Sulaiman GM, Saadoon AH (2017) Biosynthesis of silver
nanoparticles from Catharanthus roseus leaf extract and assessing their antioxidant, antimicrobial
and wound healing activities. Artif Cells Nanomed Biotechnol 45:1234–1240
Banerjee P, Nath D (2015) A phytochemical approach to synthesize silver nanoparticles for nontoxic biomedical page 2 of 14 application and study on their antibacterial efficacy. Nanosci
Technol 2(1):1–14
Bhagavathy S, Kancharla S (2016) Wound healing and angiogenesis of silver nanoparticle from
Azadirachta indica in diabetes induced mice. IJHM 4(5):24–29
Boyum A (1976) Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 5:9–15
Chaloupka K et al (2010) Nanosilver as a new generation of nanoproduct in biomedical applications.
Trends Biotechnol 28:580–588
Dissemond J, Goos M, Wagner SN (2002) The role of oxidative stress in the pathogenesis and
therapy of chronic wounds. Hautarzt 53:718–723
Garg S, Chandra A, Mazumder A, Mazumder R (2014) Green synthesis of silver nanoparticles using
Arnebia nobilis root extract and wound healing potential of its hydrogel. J Pharmac 8(2):95–101
Goia DV (2004) Preparation and formation mechanisms of uniform metallic particles in homogeneous solutions. J Mater Chem 14:451–458
Griffith M et al (2015) Anti-microbiological and anti-infective activities of silver. In: Alarcon EI
(eds) Silver nanoparticle applications: in the fabrication and design of medical and biosensing
devices. Springer, Berlin, pp 127–146
Gunasekaran T, Nigusse T, Dhanaraju MD (2011) Silver nanoparticles as real topical bullets for
wound healing. J Am Col Clin Wound Spec Spec 3:82–96
Mohanta YK, Biswas K, Panda SK, Bandhyopadhyay J, De D, Jayabalan R, Bastia AK, Mohanta
TK (2017) Phyto-assisted synthesis of biofunctionalised silver nanoparticles and their potential
anti-oxidant, anti-microbial, and wound healing activities. IET Nanobiotechnol 11:1027–1034
Mollick MMR, Bhowmick B, Mondal D, Maity D, Rana D, Dash SK, Chattopadhyay S, Roy
S, Sarkar J, Acharya K, Chakraborty M, Chattopadhyay D (2014) Anticancer (in vitro) and
antimicrobial effect of gold nanoparticles synthesized using Abelmoschus esculentus (L.) pulp
extract via a green route. RSC Adv 4:37838–37848
Ovais M, Ayaz M, Khalil AT, Shah SA, Jan MS, Raza A, Shahid M, Shinwari ZK (2018) HPLCDAD finger printing, antioxidant, cholinesterase and α glucosidase inhibitory potentials of a novel
plant Olax nana. BMC Complement Altem Med 18(1):1
Pannerselvam B, Dhamalingam Jothinathan MK, Rajenderan M, Perumal P, Pudupalayam
Thangavelu K, Kim HJ, Singh V, Rangarajulu SK (2017) An in vitro study on the burn wound
healing activity of cotton fabrics incorporated with phytosyntheiszed silver nanoparticles in male
Wister albino rats. Eur J Pharm Sci 100:187–196