Simplified Detection of Serotonin
by FET-Based Sensor
Koel Sinha, Rabindranath Majumder, and Chitrangada Das Mukhopadhyay
Abstract Qualitative and quantitative detection of neurotransmitter is crucial in
many areas, ranging from early clinical diagnosis to homeland security. Due to
various advantages such as the ultralow limit of detection, fast readout, low cost,
and easy method of fabrication over traditional detection systems, semiconductor
nanorod-based electronic devices have emerged out to be a potential sensing platform. In the present study, we synthesized biologically active ZnO nanorod fieldeffect transistor (FET)-based biosensor for the detection of different concentrations
of serotonin (5-HT) solution. In addition, serotonin ranging from lower to higher
concentration resulted in the change in electrical current with an increase in gate
voltage. The ZnO nanorod FET-based biosensor could easily detect as low as 1 fM
serotonin, which implied that the detection limit of the biosensor can be as low as
1 fM.
Keywords Neurotransmitter · Field-effect transistor · Biosensor · Serotonin
1 Introduction
Serotonin is one of the principal neurotransmitters and is regarded as the molecule
of contentment as it participates actively in controlling a number of behavioral as
well as cognitive activities (Godoy-Reyes et al. 2018). It is majorly produced by
the brain under the normal physiological condition where it functions in passing
the information to various organs through the central nervous system (Lacasse and
K. Sinha · R. Majumder · C. Das Mukhopadhyay (B)
Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and
Technology, Shibpur, Howrah, West Bengal 711103, India
e-mail: chitrangadadas@yahoo.com
K. Sinha
e-mail: ksinha2110@gmail.com
R. Majumder
e-mail: dr.rabindranath.majumder@gmail.com
© Springer Nature Singapore Pte Ltd. 2021
D. Ramkrishna et al. (eds.), Advances in Bioprocess Engineering and Technology,
Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-7409-2_4
29
by FET-Based Sensor
Koel Sinha, Rabindranath Majumder, and Chitrangada Das Mukhopadhyay
Abstract Qualitative and quantitative detection of neurotransmitter is crucial in
many areas, ranging from early clinical diagnosis to homeland security. Due to
various advantages such as the ultralow limit of detection, fast readout, low cost,
and easy method of fabrication over traditional detection systems, semiconductor
nanorod-based electronic devices have emerged out to be a potential sensing platform. In the present study, we synthesized biologically active ZnO nanorod fieldeffect transistor (FET)-based biosensor for the detection of different concentrations
of serotonin (5-HT) solution. In addition, serotonin ranging from lower to higher
concentration resulted in the change in electrical current with an increase in gate
voltage. The ZnO nanorod FET-based biosensor could easily detect as low as 1 fM
serotonin, which implied that the detection limit of the biosensor can be as low as
1 fM.
Keywords Neurotransmitter · Field-effect transistor · Biosensor · Serotonin
1 Introduction
Serotonin is one of the principal neurotransmitters and is regarded as the molecule
of contentment as it participates actively in controlling a number of behavioral as
well as cognitive activities (Godoy-Reyes et al. 2018). It is majorly produced by
the brain under the normal physiological condition where it functions in passing
the information to various organs through the central nervous system (Lacasse and
K. Sinha · R. Majumder · C. Das Mukhopadhyay (B)
Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and
Technology, Shibpur, Howrah, West Bengal 711103, India
e-mail: chitrangadadas@yahoo.com
K. Sinha
e-mail: ksinha2110@gmail.com
R. Majumder
e-mail: dr.rabindranath.majumder@gmail.com
© Springer Nature Singapore Pte Ltd. 2021
D. Ramkrishna et al. (eds.), Advances in Bioprocess Engineering and Technology,
Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-7409-2_4
29