3.3 Triple Action Antibacterial Hybrid Agents
77
Fig. 3.13 General representations of the types of three interaction point hybrids derived from a
combination starting point
are possible and with the three component starting point combination, the sites A,
B and C would be part of three separate molecules respectively. In the two component combination, the dashed line between A and B in one of the components is
meant to symbolize just one way of linking the pharmacophores amongst a number
of variations which might include for example a linking ring system. Also included
in the design progressions in Fig. 3.13 are some selected examples of molecular
frameworks incorporating A, B and C as specified by an ether group (A), a carbonyl
group (B) and a secondary amino group (C). Further detailed assessment of these
classifications is given in Sect. 3.3.3.
The first general hybrid classification is the one involving linkage of A, B, and
C in one molecular unit (Fig. 3.13). Again, the linkages could be incorporated in
a variety of ways as indicated in the general structure. The next two classifications
77
Fig. 3.13 General representations of the types of three interaction point hybrids derived from a
combination starting point
are possible and with the three component starting point combination, the sites A,
B and C would be part of three separate molecules respectively. In the two component combination, the dashed line between A and B in one of the components is
meant to symbolize just one way of linking the pharmacophores amongst a number
of variations which might include for example a linking ring system. Also included
in the design progressions in Fig. 3.13 are some selected examples of molecular
frameworks incorporating A, B and C as specified by an ether group (A), a carbonyl
group (B) and a secondary amino group (C). Further detailed assessment of these
classifications is given in Sect. 3.3.3.
The first general hybrid classification is the one involving linkage of A, B, and
C in one molecular unit (Fig. 3.13). Again, the linkages could be incorporated in
a variety of ways as indicated in the general structure. The next two classifications