46
2 Antibacterial Combinations
Butler MS, Paterson DL (2020) Antibiotics in the clinical pipeline in October 2019. J Antibiot
(Tokyo) 73 (6):329–364
Butler MS, Blaskovich MA, Cooper MA (2017) Antibiotics in the clinical pipeline at the end of
2015. J Antibiot (Tokyo) 70 (1):3–24
Conradie F, Diacon AH, Ngubane N et al. (2020) Treatment of highly drug-resistant pulmonary
tuberculosis. N Eng J Med 382(10):893–902
Calvert MB, Jumde VR, Titz A (2018) Pathoblockers or antivirulence drugs as a new option for the
treatment of bacterial infections. Beilstein J Org Chem 14:2607–2617
Chen H, Zhou X, Gao Y et al. (2014) Recent progress in development of new sonosensitizers for
sonodynamic cancer therapy. Drug Discov Today 19 (4):502–509
Chou TC (2010) Drug combination studies and their synergy quantification using the Chou-Talalay
method. Cancer Res 70 (2):440–446
Clatworthy AE, Pierson E, Hung DT (2007) Targeting virulence: a new paradigm for antimicrobial
therapy. Nat Chem Biol 3(9):541–548
Coates A (2019) The future of antibiotics lies in combination treatments. Future Drug Discov
1(1):FDD5
Costley D, Nesbitt H, Ternan N et al. (2017) Sonodynamic inactivation of Gram-positive and Gramnegative bacteria using a Rose Bengal-antimicrobial peptide conjugate. Int J Antimicrob Agents
49 (1):31–36
Crow JM (2019) The fifth element. Chem World 16(5): 48–51
Decuyper L, Jugic M, Sosic I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426-503
DeRosa MC, Crutchley RJ (2002) Photosensitized singlet oxygen and its applications. Coord Chem
Rev 233-234:351-371
Dharmaratne P, Sapugahawatte DN, Wang B et al. (2020) Contemporary approaches and
future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant
Staphylococcus aureus (MRSA): A systematic review. Eur J Med Chem 200:112341
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–17
Domalaon R, Ammeter D, Brizuela M et al. (2019) Repurposed antimicrobial combination therapy:
Tobramycin-ciprofloxacin hybrid augments activity of the anticancer drug mitomycin C against
multidrug-resistant Gram-negative bacteria. Front Microbiol 10: Article 1556
Dickey SW, Cheung GYC, Otto M (2017) Different drugs for bad bugs: antivirulence strategies in
the age of antibiotic resistance. Nat Rev Drug Discov 16 (7):457–471
El-Halfawy OM, Czarny TL, Flannagan RS et al. (2020) Discovery of an antivirulence compound
that reverses β-lactam resistance in MRSA. Nat Chem Biol 16 (2):143–149
Ferrer-Espada R, Shahrour H, Pitts B et al. (2019) A permeability-increasing drug synergizes with
bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant
Pseudomonas aeruginosa strains. Sci Rep 9 (1):3452
Fontaine F, Hequet A, Voisin-Chiret A-S et al. (2014) First identification of boronic species as
novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. J Med Chem 57
(6):2536–2548
Gomes-Fernandes M, Laabei M, Pagan N et al. (2017) Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections. PloS One 12
(4):e0175552
Gonzales PR, Pesesky MW, Bouley R et al. (2015) Synergistic, collaterally sensitive β-lactam
combinations suppress resistance in MRSA. Nat Chem Biol 11 (11):855–861
Greenberg M, Kuo D, Jankowsky E et al. (2018) Small-molecule AgrA inhibitors F12 and F19 act
as antivirulence agents against Gram-positive pathogens. Sci Rep 8 (1):14578
Gutierrez A, Jain S, Bhargava P et al. (2017) Understanding and sensitizing density-dependent
persistence to quinolone antibiotics. Mol Cell 68(6):1147–1154.e3
Hamblin MR (2017) Potentiation of antimicrobial photodynamic inactivation by inorganic salts.
Expert Rev Anti Infect Ther 15 (11):1059–1069
2 Antibacterial Combinations
Butler MS, Paterson DL (2020) Antibiotics in the clinical pipeline in October 2019. J Antibiot
(Tokyo) 73 (6):329–364
Butler MS, Blaskovich MA, Cooper MA (2017) Antibiotics in the clinical pipeline at the end of
2015. J Antibiot (Tokyo) 70 (1):3–24
Conradie F, Diacon AH, Ngubane N et al. (2020) Treatment of highly drug-resistant pulmonary
tuberculosis. N Eng J Med 382(10):893–902
Calvert MB, Jumde VR, Titz A (2018) Pathoblockers or antivirulence drugs as a new option for the
treatment of bacterial infections. Beilstein J Org Chem 14:2607–2617
Chen H, Zhou X, Gao Y et al. (2014) Recent progress in development of new sonosensitizers for
sonodynamic cancer therapy. Drug Discov Today 19 (4):502–509
Chou TC (2010) Drug combination studies and their synergy quantification using the Chou-Talalay
method. Cancer Res 70 (2):440–446
Clatworthy AE, Pierson E, Hung DT (2007) Targeting virulence: a new paradigm for antimicrobial
therapy. Nat Chem Biol 3(9):541–548
Coates A (2019) The future of antibiotics lies in combination treatments. Future Drug Discov
1(1):FDD5
Costley D, Nesbitt H, Ternan N et al. (2017) Sonodynamic inactivation of Gram-positive and Gramnegative bacteria using a Rose Bengal-antimicrobial peptide conjugate. Int J Antimicrob Agents
49 (1):31–36
Crow JM (2019) The fifth element. Chem World 16(5): 48–51
Decuyper L, Jugic M, Sosic I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426-503
DeRosa MC, Crutchley RJ (2002) Photosensitized singlet oxygen and its applications. Coord Chem
Rev 233-234:351-371
Dharmaratne P, Sapugahawatte DN, Wang B et al. (2020) Contemporary approaches and
future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant
Staphylococcus aureus (MRSA): A systematic review. Eur J Med Chem 200:112341
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–17
Domalaon R, Ammeter D, Brizuela M et al. (2019) Repurposed antimicrobial combination therapy:
Tobramycin-ciprofloxacin hybrid augments activity of the anticancer drug mitomycin C against
multidrug-resistant Gram-negative bacteria. Front Microbiol 10: Article 1556
Dickey SW, Cheung GYC, Otto M (2017) Different drugs for bad bugs: antivirulence strategies in
the age of antibiotic resistance. Nat Rev Drug Discov 16 (7):457–471
El-Halfawy OM, Czarny TL, Flannagan RS et al. (2020) Discovery of an antivirulence compound
that reverses β-lactam resistance in MRSA. Nat Chem Biol 16 (2):143–149
Ferrer-Espada R, Shahrour H, Pitts B et al. (2019) A permeability-increasing drug synergizes with
bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant
Pseudomonas aeruginosa strains. Sci Rep 9 (1):3452
Fontaine F, Hequet A, Voisin-Chiret A-S et al. (2014) First identification of boronic species as
novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. J Med Chem 57
(6):2536–2548
Gomes-Fernandes M, Laabei M, Pagan N et al. (2017) Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections. PloS One 12
(4):e0175552
Gonzales PR, Pesesky MW, Bouley R et al. (2015) Synergistic, collaterally sensitive β-lactam
combinations suppress resistance in MRSA. Nat Chem Biol 11 (11):855–861
Greenberg M, Kuo D, Jankowsky E et al. (2018) Small-molecule AgrA inhibitors F12 and F19 act
as antivirulence agents against Gram-positive pathogens. Sci Rep 8 (1):14578
Gutierrez A, Jain S, Bhargava P et al. (2017) Understanding and sensitizing density-dependent
persistence to quinolone antibiotics. Mol Cell 68(6):1147–1154.e3
Hamblin MR (2017) Potentiation of antimicrobial photodynamic inactivation by inorganic salts.
Expert Rev Anti Infect Ther 15 (11):1059–1069