Index
A
Absorption, Distribution, Metabolism and
Excretion (ADME), 5, 60, 166
Acinetobacter baumanii, 2, 34, 38, 103, 128,
160
AcrAB-TolC, 58, 75
Actinonin, 127
Acyldepsipeptides (ADEPs), 164
Adaptive drugs, solubility, permeability, 54
AgrA inhibition, inhibitors, 25
Albomycins, 64, 85
Amidase, 136, 141
Aminocoumarin, 62
Amphiphiles, 61
AN3365, 31
Angucyclic polyketide, 62
Annular interactions, 81
Antagonism, 22, 35, 43, 172
Antibacterial action, direct, 5, 15, 23
Antibacterial action, indirect, 5, 15, 22, 76,
88, 160, 176
Antibacterial
Photodynamic
Therapy
(aPDT), 37, 38, 43
Antbacterials, Chapter 1, 1
Anti-virulence, 23, 85
Archaea, 1
Artificial Intelligence (AI), 12, 57, 166, 180
Arylomycin A-C 16 , 174
ASPIRE platform, 166
Atom swapping, 70
Auranofin, 11, 107
Avibactam prodrugs, 145
Azithromycin, 15, 28, 37, 87
Azoreductase, 141
B
Bacteria, intracellular, 55, 169, 178
Bacterial antigens, 180
Bacterial chaperones, 175
Bacterial efflux, 24, 53, 88
Bacterial selectivity, 121
Bacterial transport, 177
Bactericidal agent, 22
Bactericidal outcome, 5, 22, 61, 170, 172
Bacteriodes fragilis, 179
Bacteriostatic agent, 22, 30, 137, 163
Balsalazide, 142
BamA, 175, 176
BAM complex, 176
Berberine, chemistry
cycloberberine, 74
dihydroberberine, 65, 67
electrophilic reactions, 67
nucleophilic reactions, 66
tetrahydroberberine, 66, 67
Berberine, chimeras, 95
Berberine, congeners, 95, 103
Berberine, hybrids, 74
Berberine, introduction, bioactivity, 66, 68
Berberrubine, 67, 95, 97
Biofilm formation, 6, 9, 66, 86, 89, 134
Bio-orthogonal activation of prodrugs, 146
Bio-orthogonal chemistry, 146
Bioprecursor prodrugs, 123
Blepharisma sp., 164
Blepharismin(s), 163
Boron compounds, 30, 31
Burkholderia pseudomallei, 169
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Singapore Pte Ltd. 2021
J. Bremner, Multiple Action-Based Design Approaches to Antibacterials,
https://doi.org/10.1007/978-981-16-0999-2
189
A
Absorption, Distribution, Metabolism and
Excretion (ADME), 5, 60, 166
Acinetobacter baumanii, 2, 34, 38, 103, 128,
160
AcrAB-TolC, 58, 75
Actinonin, 127
Acyldepsipeptides (ADEPs), 164
Adaptive drugs, solubility, permeability, 54
AgrA inhibition, inhibitors, 25
Albomycins, 64, 85
Amidase, 136, 141
Aminocoumarin, 62
Amphiphiles, 61
AN3365, 31
Angucyclic polyketide, 62
Annular interactions, 81
Antagonism, 22, 35, 43, 172
Antibacterial action, direct, 5, 15, 23
Antibacterial action, indirect, 5, 15, 22, 76,
88, 160, 176
Antibacterial
Photodynamic
Therapy
(aPDT), 37, 38, 43
Antbacterials, Chapter 1, 1
Anti-virulence, 23, 85
Archaea, 1
Artificial Intelligence (AI), 12, 57, 166, 180
Arylomycin A-C 16 , 174
ASPIRE platform, 166
Atom swapping, 70
Auranofin, 11, 107
Avibactam prodrugs, 145
Azithromycin, 15, 28, 37, 87
Azoreductase, 141
B
Bacteria, intracellular, 55, 169, 178
Bacterial antigens, 180
Bacterial chaperones, 175
Bacterial efflux, 24, 53, 88
Bacterial selectivity, 121
Bacterial transport, 177
Bactericidal agent, 22
Bactericidal outcome, 5, 22, 61, 170, 172
Bacteriodes fragilis, 179
Bacteriostatic agent, 22, 30, 137, 163
Balsalazide, 142
BamA, 175, 176
BAM complex, 176
Berberine, chemistry
cycloberberine, 74
dihydroberberine, 65, 67
electrophilic reactions, 67
nucleophilic reactions, 66
tetrahydroberberine, 66, 67
Berberine, chimeras, 95
Berberine, congeners, 95, 103
Berberine, hybrids, 74
Berberine, introduction, bioactivity, 66, 68
Berberrubine, 67, 95, 97
Biofilm formation, 6, 9, 66, 86, 89, 134
Bio-orthogonal activation of prodrugs, 146
Bio-orthogonal chemistry, 146
Bioprecursor prodrugs, 123
Blepharisma sp., 164
Blepharismin(s), 163
Boron compounds, 30, 31
Burkholderia pseudomallei, 169
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Singapore Pte Ltd. 2021
J. Bremner, Multiple Action-Based Design Approaches to Antibacterials,
https://doi.org/10.1007/978-981-16-0999-2
189