Chapter 5
Future Possibilities
“Think outside the square, but swim between the flags.”
—John Bremner.
On Australian surf beaches, red and yellow horizontally-banded
flags are used to designate safe swimming areas but you are still
very free to think expansively.
Abstract There are many possibilities for the future design of new multi-targeted
antibacterials based on developing knowledge of synergistic combinations and new
modes of action being discovered. This final chapter includes a comparative assessment of the combination, hybrid and prodrug approaches, together with a discussion
of the potential for using new drug combinations, especially incorporating new modes
of action, in new hybrid or prodrug designs. A concluding section covers some more
general thoughts on the need to think well outside the square in the design and development of antibacterials to help in the fight against the ever increasing threat of
resistance.
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
J. Bremner, Multiple Action-Based Design Approaches to Antibacterials,
https://doi.org/10.1007/978-981-16-0999-2_5
159
Future Possibilities
“Think outside the square, but swim between the flags.”
—John Bremner.
On Australian surf beaches, red and yellow horizontally-banded
flags are used to designate safe swimming areas but you are still
very free to think expansively.
Abstract There are many possibilities for the future design of new multi-targeted
antibacterials based on developing knowledge of synergistic combinations and new
modes of action being discovered. This final chapter includes a comparative assessment of the combination, hybrid and prodrug approaches, together with a discussion
of the potential for using new drug combinations, especially incorporating new modes
of action, in new hybrid or prodrug designs. A concluding section covers some more
general thoughts on the need to think well outside the square in the design and development of antibacterials to help in the fight against the ever increasing threat of
resistance.
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
J. Bremner, Multiple Action-Based Design Approaches to Antibacterials,
https://doi.org/10.1007/978-981-16-0999-2_5
159