154
4 Design Principles and Development of Prodrugs for Multiply …
Booth IR (2014) Bacterial mechanosensitive channels: progress towards an understanding of their
roles in cell physiology. Curr Opin Microbiol 18 (100):16–22
Bremner JB (2017) Molecular design of potential triple-action antibacterial agents and related
pro-drugs. SWU Sci J 33 (1):1–19
Bundgaard H (1989) The double prodrug concept and its applications. Adv Drug Deliv Rev 3
(1):39–65
Cai K, Lipke MC, Liu Z et al. (2018) Molecular russian dolls. Nat Commun 9 (1):5275
Canavese G, Ancona A, Racca L et al. (2018) Nanoparticle-assisted ultrasound: A special focus on
sonodynamic therapy against cancer. Chem Eng J 340:155–172
Carcamo-Noriega EN, Sathyamoorthi S, Banerjee S et al. (2019) 1,4-Benzoquinone antimicrobial
agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion
venom. Proc Natl Acad Sci 116 (26):12642–12647
Catalão MJ, Filipe SR, Pimentel M (2019) Revisiting anti-tuberculosis therapeutic strategies that
target the peptidoglycan structure and synthesis. Front Microbiol 10: Article 190
Chang G, Spencer RH, Lee AT et al. (1998) Structure of the MscL homolog from Mycobacterium
tuberculosis: A gated mechanosensitive ion channel. Science 282 (5397):2220–2226
Chen D, Yuan Z (2005) Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig
Drugs 14 (9):1107–1116
Cutruzzolà F, Frankenberg-Dinkel N (2016) Origin and Impact of Nitric Oxide in Pseudomonas
aeruginosa Biofilms. J Bacteriol 198 (1):55–65
Czuban M, Srinivasan S, Yee NA et al. (2018) Bio-orthogonal chemistry and reloadable biomaterial
enable local activation of antibiotic prodrugs and enhance treatments against Staphylococcus
aureus infections. ACS Cent Sci 4 (12):1624–1632
Das N, Dhanawat M, Dash B et al. (2010) Codrug: An efficient approach for drug optimization.
Eur J Pharm Sci 41 (5):571–588
Decuyper L, Jukiˇ c M, Sosiˇ c I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426–503
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–00017
Ehmann DE, Jahic H, Ross PL et al. (2013) Kinetics of avibactam inhibition against Class A, C,
and D β-lactamases. J Biol Chem 288 (39):27960–27971
Erttmann SF, Gekara NO (2019) Hydrogen peroxide release by bacteria suppresses inflammasomedependent innate immunity. Nat Commun 10 (1):3493
Evans LE, Krishna A, Ma Y et al. (2019) Exploitation of antibiotic resistance as a novel drug target:
Development of a β-lactamase-activated antibacterial prodrug. J Med Chem 62 (9):4411–4425
Feringa BL (2017) The art of building small: From molecular switches to motors (Nobel Lecture).
Angew Chem Int Ed 56 (37):11060–11078
Fieulaine S, Rodolphe ADS, Maigre L et al. (2016) A unique peptide deformylase platform to
rationally design and challenge novel active compounds. Sci Rep 6:35429
Gilmer JF (2017). Towards gaseous mediator hybrid drugs. In: Decker M (ed) Design of hybrid
molecules for drug development. 1st edn. Elsevier, Amsterdam, pp 47–81
Gong W, Yang X, Zavalij PY et al. (2016) From packed “Sandwich” to “Russian Doll”: Assembly
by charge-transfer interactions in cucurbit[10]uril. Chem Eur J 22 (49):17612–17618
Gordon EM, Duncton MAJ, Gallop MA (2018) Orally absorbed derivatives of the β-lactamase
inhibitor avibactam. Design of novel prodrugs of sulfate containing drugs. J Med Chem 61
(22):10340–10344
Grant JW, Smyth TP (2004) Toward the development of a cephalosporin-based dual-release prodrug
for use in ADEPT. J Org Chem 69 (23):7965–7970
Haswell ES, Phillips R, Rees DC (2011) Mechanosensitive channels: what can they do and how do
they do it? Structure 19 (10):1356–1369
Helgren TR, Wangtrakuldee P, Staker BL et al. (2016) Advances in bacterial methionine
aminopeptidase inhibition. Curr Top Med Chem 16 (4):397–414
4 Design Principles and Development of Prodrugs for Multiply …
Booth IR (2014) Bacterial mechanosensitive channels: progress towards an understanding of their
roles in cell physiology. Curr Opin Microbiol 18 (100):16–22
Bremner JB (2017) Molecular design of potential triple-action antibacterial agents and related
pro-drugs. SWU Sci J 33 (1):1–19
Bundgaard H (1989) The double prodrug concept and its applications. Adv Drug Deliv Rev 3
(1):39–65
Cai K, Lipke MC, Liu Z et al. (2018) Molecular russian dolls. Nat Commun 9 (1):5275
Canavese G, Ancona A, Racca L et al. (2018) Nanoparticle-assisted ultrasound: A special focus on
sonodynamic therapy against cancer. Chem Eng J 340:155–172
Carcamo-Noriega EN, Sathyamoorthi S, Banerjee S et al. (2019) 1,4-Benzoquinone antimicrobial
agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion
venom. Proc Natl Acad Sci 116 (26):12642–12647
Catalão MJ, Filipe SR, Pimentel M (2019) Revisiting anti-tuberculosis therapeutic strategies that
target the peptidoglycan structure and synthesis. Front Microbiol 10: Article 190
Chang G, Spencer RH, Lee AT et al. (1998) Structure of the MscL homolog from Mycobacterium
tuberculosis: A gated mechanosensitive ion channel. Science 282 (5397):2220–2226
Chen D, Yuan Z (2005) Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig
Drugs 14 (9):1107–1116
Cutruzzolà F, Frankenberg-Dinkel N (2016) Origin and Impact of Nitric Oxide in Pseudomonas
aeruginosa Biofilms. J Bacteriol 198 (1):55–65
Czuban M, Srinivasan S, Yee NA et al. (2018) Bio-orthogonal chemistry and reloadable biomaterial
enable local activation of antibiotic prodrugs and enhance treatments against Staphylococcus
aureus infections. ACS Cent Sci 4 (12):1624–1632
Das N, Dhanawat M, Dash B et al. (2010) Codrug: An efficient approach for drug optimization.
Eur J Pharm Sci 41 (5):571–588
Decuyper L, Jukiˇ c M, Sosiˇ c I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426–503
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–00017
Ehmann DE, Jahic H, Ross PL et al. (2013) Kinetics of avibactam inhibition against Class A, C,
and D β-lactamases. J Biol Chem 288 (39):27960–27971
Erttmann SF, Gekara NO (2019) Hydrogen peroxide release by bacteria suppresses inflammasomedependent innate immunity. Nat Commun 10 (1):3493
Evans LE, Krishna A, Ma Y et al. (2019) Exploitation of antibiotic resistance as a novel drug target:
Development of a β-lactamase-activated antibacterial prodrug. J Med Chem 62 (9):4411–4425
Feringa BL (2017) The art of building small: From molecular switches to motors (Nobel Lecture).
Angew Chem Int Ed 56 (37):11060–11078
Fieulaine S, Rodolphe ADS, Maigre L et al. (2016) A unique peptide deformylase platform to
rationally design and challenge novel active compounds. Sci Rep 6:35429
Gilmer JF (2017). Towards gaseous mediator hybrid drugs. In: Decker M (ed) Design of hybrid
molecules for drug development. 1st edn. Elsevier, Amsterdam, pp 47–81
Gong W, Yang X, Zavalij PY et al. (2016) From packed “Sandwich” to “Russian Doll”: Assembly
by charge-transfer interactions in cucurbit[10]uril. Chem Eur J 22 (49):17612–17618
Gordon EM, Duncton MAJ, Gallop MA (2018) Orally absorbed derivatives of the β-lactamase
inhibitor avibactam. Design of novel prodrugs of sulfate containing drugs. J Med Chem 61
(22):10340–10344
Grant JW, Smyth TP (2004) Toward the development of a cephalosporin-based dual-release prodrug
for use in ADEPT. J Org Chem 69 (23):7965–7970
Haswell ES, Phillips R, Rees DC (2011) Mechanosensitive channels: what can they do and how do
they do it? Structure 19 (10):1356–1369
Helgren TR, Wangtrakuldee P, Staker BL et al. (2016) Advances in bacterial methionine
aminopeptidase inhibition. Curr Top Med Chem 16 (4):397–414