4.2 Introduction to Prodrugs for Triple or Higher Action …
139
(A)
(B)
(C)
Scheme 4.4 A suggested monobactam-based prodrug and proposed fragmention scheme to release
ciprofloxacin and two other potentially bioactive compounds
biological action. The cytoplasmic enzyme peptide deformylase might be considered
for cleavage of the terminal C--X linkage (Sangshetti et al. 2015). This enzyme does
have some substrate tolerance and the intermediate or final amine generated in the
formamide hydrolysis process could then serve as a subsequent chemical trigger to
release a triple action antibacterial agent in high concentration intracellularly.
139
(A)
(B)
(C)
Scheme 4.4 A suggested monobactam-based prodrug and proposed fragmention scheme to release
ciprofloxacin and two other potentially bioactive compounds
biological action. The cytoplasmic enzyme peptide deformylase might be considered
for cleavage of the terminal C--X linkage (Sangshetti et al. 2015). This enzyme does
have some substrate tolerance and the intermediate or final amine generated in the
formamide hydrolysis process could then serve as a subsequent chemical trigger to
release a triple action antibacterial agent in high concentration intracellularly.