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Samosorn S, Tanwirat B, Muhamad N et al. (2009) Antibacterial activity of berberine-NorA pump
inhibitor hybrids with a methylene ether linking group. Bioorg Med Chem 17 (11):3866–3872
Schindler B, Jacinto P, Kaatz G (2013) Inhibition of drug efflux pumps in Staphylococcus aureus:
Current status of potentiating existing antibiotics. Future Microbiol 8:491–507
Schwarz B, Merkel OM (2019) Nose-to-brain delivery of biologics. Ther Deliv 10 (4):207–210
Sebastiano MR, Doak BC, Backlund M et al. (2018) Impact of dynamically exposed polarity on
permeability and solubility of chameleonic drugs beyond the rule of 5. J Med Chem 61:4189–4202
Shapiro, S. 2013. Speculative strategies for new antibacterials: All roads should not lead to Rome.
J Antibiot 66: 371–386
Shavit M, Pokrovskaya V, Belakhov V et al. (2017) Covalently-linked kanamycin-ciprofloxacin
hybrid antibiotics as a tool to fight bacterial resistance. Bioorg Med Chem 25(11): 2917–2925
Shukla R, Medeiros-Silva J, Parmar A et al. (2020) Mode of action of teixobactins in cellular
membranes. Nat Commun 11 (1):2848
Silver LL (2007) Multi-targeting by monotherapeutic antibacterials. Nat Rev Drug Discov 6 (1):41–
55
Simoni E, Daniele S, Bottegoni G et al. (2012) Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer’s disease. J Med Chem 55
(22):9708–9721
Sowaileh MF, Hazlitt RA, Colby DA (2017) Application of the pentafluorosulfanyl group as a
bioisosteric replacement. ChemMedChem 12: 1481–490
Stokes N, Baker N, Bennett J et al. (2013) An improved small-molecule inhibitor of FtsZ with
superior in vitro potency, drug-like properties, and in vivo efficacy. Antimicrob Agents Chemother
57 (1):317–325
Stokes JM, MacNair CR, Ilyas B et al. (2017) Pentamidine sensitizes Gram-negative pathogens to
antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2: 17028
Stoodley RJ (1977) Aspects of heterocyclic synthesis. Chem Ind 8 (39):377–385
Sun N, Chan F-Y, Lu Y-J et al. (2014) Rational design of berberine-based FtsZ inhibitors with
broad-spectrum antibacterial activity. PloS one 9 (5):e97514–e97514
Sun T, Li X-D, Hong J et al. (2019) Inhibitory effect of two traditional chinese medicine monomers,
Berberine and Matrine, on the quorum sensing system of antimicrobial-resistant Escherichia coli.
Front Microbiol 10:2584–2584
Tague AJ, Putsathit P, Hutton ML et al. (2019a) Cationic biaryl 1,2,3-triazolyl peptidomimetic
amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation
and an in vivo C. difficile infection model. Eur J Med Chem 170:203–224
Tague AJ, Putsathit P, Hammer KA et al. (2019b) Cationic biaryl 1,2,3-triazolyl peptidomimetic
amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies.
Eur J Chem 168:386–404
Tahir S, Mahmood T, Dastgir F et al. (2019) Design, synthesis and anti-bacterial studies of piperazine
derivatives against drug resistant bacteria. Eur J Med Chem 166:224–231
Tambat R, Jangra M, Mahey N et al. (2019) Microbe-derived indole metabolite demonstrates potent
multidrug efflux pump inhibition in Staphylococcus aureus. Front Microbiol 10:2153–2153
Tang X, Zhang J, Liu L et al. (2017) Synthesis of 13-substituted derivatives of berberine:
Aggregation-induced emission enhancement and pH sensitive property. J Photochem Photobiol
A 337:71–81
Teng Q, Zhu X, Guo Q et al. (2019) Synthesis of 9-O-arylated berberines via copper-catalyzed
C(Ar)-O coupling reactions. Beilstein J Org Chem 15:1575–1580
Tevyashova A, Olsuf’eva E, Preobrazhenskaya M (2015) Design of dual action antibiotics as an
approach to search for new promising drugs. Russ Chem Rev 84:61–97
Thangamani S, Mohammad H, Abushahba MFN et al. (2016) Antibacterial activity and mechanism
of action of auranofin against multi-drug resistant bacterial pathogens. Sci. Rep 6:22571
Thirumurugan P, Matosiuk D, Jozwiak K (2013) Click chemistry for drug development and diverse
chemical-biology applications. Chem Rev 113(7): 4905–4979