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(2016) Regulation of cell growth and apoptosis through lactate dehydrogenase C overexpression in Chinese hamster ovary cells. Appl Microbiol Biotechnol 100:5007–5016
97. Andersen DC, Goochee CF (1995) The effect of ammonia on the O-linked glycosylation of
granulocyte colony-stimulating factor produced by chinese hamster ovary cells. Biotechnol
Bioeng 47:96–105
98. Ha TK, Kim Y-G, Lee GM (2015) Understanding of altered N-glycosylation-related gene
expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium
concentration by digital mRNA counting. Biotechnol Bioeng 112:1583–1593
Digital Twins and Their Role in Model-Assisted Design of Experiments
61