Fig. 2
Schematic outline of state-of-the-art methods for bioprocess scale-down. Scale-down starts with an analysis of the industrial large-scale bioprocess.
While current approaches dominate in
fluid dynamic characterization, the generation of a reliable cell model (digital twin) and the characterization of the cellular
reaction dynamics, i.e. parametrization of the model, are most important for scale-down experiments. The three pillars of bioprocess characterization are
highlighted in colors: reactor (blue), cell (green), populations (red)
Potential of Integrating Model-Based Design of Experiments Approaches and. . .
11
Schematic outline of state-of-the-art methods for bioprocess scale-down. Scale-down starts with an analysis of the industrial large-scale bioprocess.
While current approaches dominate in
fluid dynamic characterization, the generation of a reliable cell model (digital twin) and the characterization of the cellular
reaction dynamics, i.e. parametrization of the model, are most important for scale-down experiments. The three pillars of bioprocess characterization are
highlighted in colors: reactor (blue), cell (green), populations (red)
Potential of Integrating Model-Based Design of Experiments Approaches and. . .
11