337
Natl Acad Sci USA 91(22):10747–10751.
doi:10.1073/pnas.91.22.10747
6. Eyre-Walker A, Keightley PD (2007) The distribution of fitness effects of new mutations.
Nat Rev Genet 8(8):610–618. doi:10.1038/
nrg2146
7. Jackel C, Hilvert D (2010) Biocatalysts by evolution. Curr Opin Biotechnol 21(6):753–759.
doi:10.1016/j.copbio.2010.08.008
8. Tracewell CA, Arnold FH (2009) Directed
enzyme evolution: climbing fitness peaks one
amino acid at a time. Curr Opin Chem Biol
13(1):3–9. doi:10.1016/j.cbpa.2009.01.017
9. Szybalski W, Kim SC, Hasan N, Podhajska AJ
(1991) Class-IIS restriction enzymes – a review.
Gene
100:13–26.
doi:10.1016/0378–
1119(91)90345-C
10. Di Roberto RB, Peisajovich SG (2014) The
role of domain shuffling in the evolution of signaling networks. J Exp Zool B Mol Dev Evol
322(2):65–72. doi:10.1002/jez.b.22551
11. Lai A, Sato PM, Peisajovich SG (2015)
Evolution of synthetic signaling scaffolds by
recombination of modular protein domains.
ACS Synth Biol 4(6):714–722. doi:10.1021/
sb5003482
12. Peisajovich SG, Garbarino JE, Wei P, Lim WA
(2010) Rapid diversification of cell signaling
phenotypes by modular domain recombination.
Science 328(5976):368–372. doi:10.1126/
science.1182376
13. Sato PM, Yoganathan K, Jung JH, Peisajovich
SG (2014) The robustness of a signaling complex to domain rearrangements facilitates network
evolution.
PLoS
Biol
12(12).
doi:10.1371/journal.pbio.1002012
14. Di Roberto RB, Chang B, Trusina A,
Peisajovich SG (2016) Evolution of a G
protein- coupled receptor response by mutations in regulatory network interactions.
Nat Commun 7:12344. doi:10.1038/
ncomms12344
15. Gietz RD, Woods RA (2002) Transformation
of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method.
Methods Enzymol 350:87–96
Rewiring Signaling Networks
Natl Acad Sci USA 91(22):10747–10751.
doi:10.1073/pnas.91.22.10747
6. Eyre-Walker A, Keightley PD (2007) The distribution of fitness effects of new mutations.
Nat Rev Genet 8(8):610–618. doi:10.1038/
nrg2146
7. Jackel C, Hilvert D (2010) Biocatalysts by evolution. Curr Opin Biotechnol 21(6):753–759.
doi:10.1016/j.copbio.2010.08.008
8. Tracewell CA, Arnold FH (2009) Directed
enzyme evolution: climbing fitness peaks one
amino acid at a time. Curr Opin Chem Biol
13(1):3–9. doi:10.1016/j.cbpa.2009.01.017
9. Szybalski W, Kim SC, Hasan N, Podhajska AJ
(1991) Class-IIS restriction enzymes – a review.
Gene
100:13–26.
doi:10.1016/0378–
1119(91)90345-C
10. Di Roberto RB, Peisajovich SG (2014) The
role of domain shuffling in the evolution of signaling networks. J Exp Zool B Mol Dev Evol
322(2):65–72. doi:10.1002/jez.b.22551
11. Lai A, Sato PM, Peisajovich SG (2015)
Evolution of synthetic signaling scaffolds by
recombination of modular protein domains.
ACS Synth Biol 4(6):714–722. doi:10.1021/
sb5003482
12. Peisajovich SG, Garbarino JE, Wei P, Lim WA
(2010) Rapid diversification of cell signaling
phenotypes by modular domain recombination.
Science 328(5976):368–372. doi:10.1126/
science.1182376
13. Sato PM, Yoganathan K, Jung JH, Peisajovich
SG (2014) The robustness of a signaling complex to domain rearrangements facilitates network
evolution.
PLoS
Biol
12(12).
doi:10.1371/journal.pbio.1002012
14. Di Roberto RB, Chang B, Trusina A,
Peisajovich SG (2016) Evolution of a G
protein- coupled receptor response by mutations in regulatory network interactions.
Nat Commun 7:12344. doi:10.1038/
ncomms12344
15. Gietz RD, Woods RA (2002) Transformation
of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method.
Methods Enzymol 350:87–96
Rewiring Signaling Networks