318
1. Deribe YL, Pawson T, Dikic I (2010) Posttranslational modifications in signal integration. Nat Struct Mol Biol 17:666–672
2. Hunter T (1995) Protein kinases and phosphatases: review the yin and yang of protein phosphorylation and signaling. Cell 80:225–236
3. Sharma K, D’Souza RCJ, Tyanova S et al
(2014) Ultradeep human phosphoproteome
reveals a distinct regulatory nature of Tyr and
Ser/Thr-based
signaling.
Cell
Rep
8:1583–1594
4. Hornbeck PV, Kornhauser JM, Tkachev S et al
(2011) PhosphoSitePlus: a comprehensive
resource for investigating the structure and
function of experimentally determined posttranslational modifications in man and mouse.
Nucleic Acids Res 40:D261–D270
5. Manning G (2002) The protein kinase complement of the human genome. Science
298:1912–1934
6. Cohen P (2002) Protein kinases: the major
drug targets of the twenty-first century? Nat
Rev Drug Discov 1:309–315
7. Hotamisligil GS (2006) Inflammation and
metabolic disorders. Nature 444:860–867
8. Kyriakis JM, Avruch J (2012) Mammalian
MAPK signal transduction pathways activated
by stress and inflammation: a 10-year update.
Physiol Rev 92:689–737
9. Mueller BK, Mack H, Teusch N (2005) Rho
kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov
4:387–398
10. Knight ZA, Lin H, Shokat KM (2010)
Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 10:130–137
11. Zhang J, Yang PL, Gray NS (2009) Targeting
cancer with small molecule kinase inhibitors.
Nat Rev Cancer 9:28–39
12. Lamba V, Ghosh I (2012) New directions in
targeting protein kinases: focusing upon true
allosteric and bivalent inhibitors. Curr Pharm
Des 18:2936–2945
13. Krebs EG, Fischer EH (1956) The phosphorylase b to a converting enzyme of rabbit skeletal
muscle. Biochim Biophys Acta 20:150–157
14. Hunter T, Sefton BM (1980) Transforming
gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci
77:1311–1315
15. Hubbard SR, Till JH (2000) Protein tyrosine
kinase structure and function. Annu Rev
Biochem 69:373–398
16. Endicott JA, Noble MEM, Johnson LN (2012)
The structural basis for control of eukaryotic
protein kinases. Annu Rev Biochem
81:587–613
17. Taylor SS, Kornev AP (2011) Protein kinases:
evolution of dynamic regulatory proteins.
Trends Biochem Sci 36:65–77
18. Bishop AC, Kung C-Y, Shah K et al (1999)
Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic
approach. J Am Chem Soc 121:627–631
19. Liu Y, Shah K, Yang F et al (1998) Engineering
Src family protein kinases with unnatural
nucleotide specificity. Chem Biol 5:91–101
20. Bishop AC, Ubersax JA, Petsch DT et al (2000)
A chemical switch for inhibitor- sensitive alleles of
any protein kinase. Nature 407:395–401
21. Karginov AV, Ding F, Kota P et al (2010)
Engineered allosteric activation of kinases in
living cells. Nat Biotechnol 28:743–747
22. Karginov AV, Zou Y, Shirvanyants D et al
(2011) Light regulation of protein dimerization and kinase activity in living cells using
photocaged rapamycin and engineered FKBP. J
Am Chem Soc 133:420–423
23. Gautier A, Nguyen DP, Lusic H et al (2010)
Genetically encoded photocontrol of protein
localization in mammalian cells. J Am Chem
Soc 132:4086–4088
24. Shekhawat SS, Ghosh I (2011) Split-protein
systems: beyond binary protein–protein interactions. Curr Opin Chem Biol 15:789–797
25. Camacho-Soto K, Castillo-Montoya J, Tye B,
Ghosh I (2014) Ligand-gated split-kinases.
J Am Chem Soc 136:3995–4002
26. Camacho-Soto K, Castillo-Montoya J, Tye B
et al (2014) Small molecule gated split-tyrosine
phosphatases and orthogonal split-tyrosine
kinases. J Am Chem Soc 136:17078–17086
27. Fegan A, White B, Carlson JCT, Wagner CR
(2010) Chemically controlled protein assembly: techniques and applications. Chem Rev
110:3315–3336. doi:10.1021/cr8002888
28. Liang FS, Ho WQ, Crabtree GR (2011)
Engineering the ABA plant stress pathway for
regulation of induced proximity. Sci Signal 4:rs2
29. Miyazono K-I, Miyakawa T, Sawano Y et al
(2009) Structural basis of abscisic acid signalling. Nature 462:609–614
30. Miyamoto T, DeRose R, Suarez A et al (2012)
Rapid and orthogonal logic gating with a
gibberellin- induced dimerization system. Nat
Chem Biol 8:465–470
References
Javier Castillo-Montoya and Indraneel Ghosh
1. Deribe YL, Pawson T, Dikic I (2010) Posttranslational modifications in signal integration. Nat Struct Mol Biol 17:666–672
2. Hunter T (1995) Protein kinases and phosphatases: review the yin and yang of protein phosphorylation and signaling. Cell 80:225–236
3. Sharma K, D’Souza RCJ, Tyanova S et al
(2014) Ultradeep human phosphoproteome
reveals a distinct regulatory nature of Tyr and
Ser/Thr-based
signaling.
Cell
Rep
8:1583–1594
4. Hornbeck PV, Kornhauser JM, Tkachev S et al
(2011) PhosphoSitePlus: a comprehensive
resource for investigating the structure and
function of experimentally determined posttranslational modifications in man and mouse.
Nucleic Acids Res 40:D261–D270
5. Manning G (2002) The protein kinase complement of the human genome. Science
298:1912–1934
6. Cohen P (2002) Protein kinases: the major
drug targets of the twenty-first century? Nat
Rev Drug Discov 1:309–315
7. Hotamisligil GS (2006) Inflammation and
metabolic disorders. Nature 444:860–867
8. Kyriakis JM, Avruch J (2012) Mammalian
MAPK signal transduction pathways activated
by stress and inflammation: a 10-year update.
Physiol Rev 92:689–737
9. Mueller BK, Mack H, Teusch N (2005) Rho
kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov
4:387–398
10. Knight ZA, Lin H, Shokat KM (2010)
Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 10:130–137
11. Zhang J, Yang PL, Gray NS (2009) Targeting
cancer with small molecule kinase inhibitors.
Nat Rev Cancer 9:28–39
12. Lamba V, Ghosh I (2012) New directions in
targeting protein kinases: focusing upon true
allosteric and bivalent inhibitors. Curr Pharm
Des 18:2936–2945
13. Krebs EG, Fischer EH (1956) The phosphorylase b to a converting enzyme of rabbit skeletal
muscle. Biochim Biophys Acta 20:150–157
14. Hunter T, Sefton BM (1980) Transforming
gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci
77:1311–1315
15. Hubbard SR, Till JH (2000) Protein tyrosine
kinase structure and function. Annu Rev
Biochem 69:373–398
16. Endicott JA, Noble MEM, Johnson LN (2012)
The structural basis for control of eukaryotic
protein kinases. Annu Rev Biochem
81:587–613
17. Taylor SS, Kornev AP (2011) Protein kinases:
evolution of dynamic regulatory proteins.
Trends Biochem Sci 36:65–77
18. Bishop AC, Kung C-Y, Shah K et al (1999)
Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic
approach. J Am Chem Soc 121:627–631
19. Liu Y, Shah K, Yang F et al (1998) Engineering
Src family protein kinases with unnatural
nucleotide specificity. Chem Biol 5:91–101
20. Bishop AC, Ubersax JA, Petsch DT et al (2000)
A chemical switch for inhibitor- sensitive alleles of
any protein kinase. Nature 407:395–401
21. Karginov AV, Ding F, Kota P et al (2010)
Engineered allosteric activation of kinases in
living cells. Nat Biotechnol 28:743–747
22. Karginov AV, Zou Y, Shirvanyants D et al
(2011) Light regulation of protein dimerization and kinase activity in living cells using
photocaged rapamycin and engineered FKBP. J
Am Chem Soc 133:420–423
23. Gautier A, Nguyen DP, Lusic H et al (2010)
Genetically encoded photocontrol of protein
localization in mammalian cells. J Am Chem
Soc 132:4086–4088
24. Shekhawat SS, Ghosh I (2011) Split-protein
systems: beyond binary protein–protein interactions. Curr Opin Chem Biol 15:789–797
25. Camacho-Soto K, Castillo-Montoya J, Tye B,
Ghosh I (2014) Ligand-gated split-kinases.
J Am Chem Soc 136:3995–4002
26. Camacho-Soto K, Castillo-Montoya J, Tye B
et al (2014) Small molecule gated split-tyrosine
phosphatases and orthogonal split-tyrosine
kinases. J Am Chem Soc 136:17078–17086
27. Fegan A, White B, Carlson JCT, Wagner CR
(2010) Chemically controlled protein assembly: techniques and applications. Chem Rev
110:3315–3336. doi:10.1021/cr8002888
28. Liang FS, Ho WQ, Crabtree GR (2011)
Engineering the ABA plant stress pathway for
regulation of induced proximity. Sci Signal 4:rs2
29. Miyazono K-I, Miyakawa T, Sawano Y et al
(2009) Structural basis of abscisic acid signalling. Nature 462:609–614
30. Miyamoto T, DeRose R, Suarez A et al (2012)
Rapid and orthogonal logic gating with a
gibberellin- induced dimerization system. Nat
Chem Biol 8:465–470
References
Javier Castillo-Montoya and Indraneel Ghosh