92
H. Zhu et al.
HN
O O
HN
O O
PyiF
RO
RO
[H], [O] shunt
RO
HN
O
OH
OH
OH
RO
HN
O
OH
OH
OH
RO
HN
O
OH
OH
OH
HO
O
HN
O
OH
OH
OH
OH
O
HN
O
OH
OH
OH
OH
OH
+H 2 O
[O]
[O]
[H]
B10: R = CH 3
B11: R = H
B14: R = CH 3
B15: R = H
B12: R = CH 3
B13: R = H
B8: R = CH 3
D
in vivo
HN
O OAc
O
OH
OH
164 (pyrichalasin H)
B16
B17
B7
B9: R = H
Scheme 3 (continued)