130
H. Zhu et al.
250. Khaldi N, Collemare J, Lebrun MH, Wolfe KH (2008) Evidence for horizontal transfer of a
secondary metabolite gene cluster between fungi. Genome Biol 9:R18
251. Song Z, Bakeer W, Marshall JW, Yakasai AA, Khalid RM, Collemare J, Skellam E, Tharreau
D, Lebrun MH, Lazarus CM, Bailey AM, Simpson TJ, Cox RJ (2015) Heterologous expression
of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae. Chem Sci
6:4837
252. Nielsen ML, Isbrandt T, Petersen LM, Mortensen UH, Andersen MR, Hoof JB, Larsen TO
(2016) Linker flexibility facilitates module exchange in fungal hybrid PKS-NRPS engineering.
PLoS One 11:e0161199/1
253. Schümann J, Hertweck C (2007) Molecular basis of cytochalasan biosynthesis in fungi: gene
cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA
silencing. J Am Chem Soc 129:9564
254. Song ZS, Cox RJ, Lazarus CM, Simpson TJ (2004) Fusarin C biosynthesis in Fusarium
moniliforme and Fusarium venenatum. ChemBioChem 5:1196
255. Sims JW, Fillmore JP, Warner DD, Schmidt EW (2005) Equisetin biosynthesis in Fusarium
heterosporum. Chem Commun 2005:186
256. Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ (2007)
Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.
ChemBioChem 8:289
257. Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007)
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.
Nat Chem Biol 3:213
258. Fisch KM (2013) Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS.
RSC Adv 3:18228
259. Ishiuchi KI, Nakazawa T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K
(2013) Combinatorial generation of complexity by redox enzymes in the chaetoglobosin
A biosynthesis. J Am Chem Soc 135:7371
260. Qiao K, Chooi YH, Tang Y (2011) Identification and engineering of the cytochalasin gene
cluster from Aspergillus clavatus NRRL 1. Metab Eng 13:723
261. Moore GG, Collemare J, Lebrun MH, Bradshaw RE (2014) Natural products, part 2. Evolving
pathways, evolutionary mechanisms involved in development of fungal secondary metabolite
gene clusters. In: Osbourn A, Goss RJ, Carter GT (eds) Natural products: discourse, diversity,
and design. Wiley, Inc., Hoboken, NJ, USA, p 343
262. Fujii R, Minami A, Gomi K, Oikawa H (2013) Biosynthetic assembly of cytochalasin
backbone. Tetrahedron Lett 54:2999
263. Thomas EJ (1991) Cytochalasan synthesis: macrocycle formation via intramolecular DielsAlder reactions. Acc Chem Res 24:229
264. Oikawa H, Murakami Y, Ichihara A (1992) Biosynthetic study of chaetoglobosin-A: origins
of the oxygen and hydrogen atoms, and indirect evidence for biological Diels-Alder reaction.
J Chem Soc Perkin Trans I 1992:2955
265. Li L, Yu P, Tang MC, Zou Y, Gao SS, Hung YS, Zhao M, Watanabe K, Houk KN, Tang Y
(2016) Biochemical characterization of a eukaryotic decalin-forming Diels-Alderase. J Am
Chem Soc 138:15837
266. Hantke V, Skellam EJ, Cox RJ (2020) Evidence for enzyme catalysed intramolecular [4 + 2]
Diels-Alder cyclization during the biosynthesis of pyrichalasin H. Chem Commun 56:2925
267. Hu Y, Dietrich D, Xu W, Patel A, Thuss JAJ, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC,
Tang Y (2014) A carbonate-forming Baeyer-Villiger monooxygenase. Nat Chem Biol 10:552
268. Stork G, Nakahara Y, Nakahara Y, Greenlee WJ (1978) Total synthesis of cytochalasin B. J
Am Chem Soc 100:7775
269. Haidle AM, Myers AG (2004) An enantioselective, modular, and general route to the
cytochalasins: synthesis of L-696,474 and cytochalasin B. Proc Natl Acad Sci USA 101:12048
270. Aboujaoude EE, Collignon N, Savignac P (1984) Synthese de phosphonates β-carbonyles: I.
Par voie carbanionique. J Organomet Chem 264:9
H. Zhu et al.
250. Khaldi N, Collemare J, Lebrun MH, Wolfe KH (2008) Evidence for horizontal transfer of a
secondary metabolite gene cluster between fungi. Genome Biol 9:R18
251. Song Z, Bakeer W, Marshall JW, Yakasai AA, Khalid RM, Collemare J, Skellam E, Tharreau
D, Lebrun MH, Lazarus CM, Bailey AM, Simpson TJ, Cox RJ (2015) Heterologous expression
of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae. Chem Sci
6:4837
252. Nielsen ML, Isbrandt T, Petersen LM, Mortensen UH, Andersen MR, Hoof JB, Larsen TO
(2016) Linker flexibility facilitates module exchange in fungal hybrid PKS-NRPS engineering.
PLoS One 11:e0161199/1
253. Schümann J, Hertweck C (2007) Molecular basis of cytochalasan biosynthesis in fungi: gene
cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA
silencing. J Am Chem Soc 129:9564
254. Song ZS, Cox RJ, Lazarus CM, Simpson TJ (2004) Fusarin C biosynthesis in Fusarium
moniliforme and Fusarium venenatum. ChemBioChem 5:1196
255. Sims JW, Fillmore JP, Warner DD, Schmidt EW (2005) Equisetin biosynthesis in Fusarium
heterosporum. Chem Commun 2005:186
256. Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ (2007)
Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.
ChemBioChem 8:289
257. Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007)
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.
Nat Chem Biol 3:213
258. Fisch KM (2013) Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS.
RSC Adv 3:18228
259. Ishiuchi KI, Nakazawa T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K
(2013) Combinatorial generation of complexity by redox enzymes in the chaetoglobosin
A biosynthesis. J Am Chem Soc 135:7371
260. Qiao K, Chooi YH, Tang Y (2011) Identification and engineering of the cytochalasin gene
cluster from Aspergillus clavatus NRRL 1. Metab Eng 13:723
261. Moore GG, Collemare J, Lebrun MH, Bradshaw RE (2014) Natural products, part 2. Evolving
pathways, evolutionary mechanisms involved in development of fungal secondary metabolite
gene clusters. In: Osbourn A, Goss RJ, Carter GT (eds) Natural products: discourse, diversity,
and design. Wiley, Inc., Hoboken, NJ, USA, p 343
262. Fujii R, Minami A, Gomi K, Oikawa H (2013) Biosynthetic assembly of cytochalasin
backbone. Tetrahedron Lett 54:2999
263. Thomas EJ (1991) Cytochalasan synthesis: macrocycle formation via intramolecular DielsAlder reactions. Acc Chem Res 24:229
264. Oikawa H, Murakami Y, Ichihara A (1992) Biosynthetic study of chaetoglobosin-A: origins
of the oxygen and hydrogen atoms, and indirect evidence for biological Diels-Alder reaction.
J Chem Soc Perkin Trans I 1992:2955
265. Li L, Yu P, Tang MC, Zou Y, Gao SS, Hung YS, Zhao M, Watanabe K, Houk KN, Tang Y
(2016) Biochemical characterization of a eukaryotic decalin-forming Diels-Alderase. J Am
Chem Soc 138:15837
266. Hantke V, Skellam EJ, Cox RJ (2020) Evidence for enzyme catalysed intramolecular [4 + 2]
Diels-Alder cyclization during the biosynthesis of pyrichalasin H. Chem Commun 56:2925
267. Hu Y, Dietrich D, Xu W, Patel A, Thuss JAJ, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC,
Tang Y (2014) A carbonate-forming Baeyer-Villiger monooxygenase. Nat Chem Biol 10:552
268. Stork G, Nakahara Y, Nakahara Y, Greenlee WJ (1978) Total synthesis of cytochalasin B. J
Am Chem Soc 100:7775
269. Haidle AM, Myers AG (2004) An enantioselective, modular, and general route to the
cytochalasins: synthesis of L-696,474 and cytochalasin B. Proc Natl Acad Sci USA 101:12048
270. Aboujaoude EE, Collignon N, Savignac P (1984) Synthese de phosphonates β-carbonyles: I.
Par voie carbanionique. J Organomet Chem 264:9