23. Lovering F, Bikker J, Humblet C (2009) Escape from flatland: increasing saturation as an
approach to improving clinical success. J Med Chem 52:6752–6756
24. García-Antón J, Axet MR, Jansat S, Philippot K, Chaudret B, Pery T, Buntkowsky G,
Limbach HH (2008) Reactions of olefins with ruthenium hydride nanoparticles: NMR characterization, hydride titration, and room-temperature C–C bond activation. Angew Chem Int
Ed 47:2074–2078
25. Hu Y, Yu Y, Hou Z, Li H, Zhao X, Feng B (2008) Biphasic hydrogenation of olefins by
functionalized ionic liquid-stabilized palladium nanoparticles. Adv Synth Catal
350:2077–2085
26. Fiorio JL, López N, Rossi LM (2017) Gold–ligand-catalyzed selective hydrogenation of
alkynes into cis-alkenes via H2 Heterolytic activation by frustrated Lewis Pairs. ACS Catal
7:2973–2980
27. Delgado JA, Benkirane O, Claver C, Curulla-Ferre D, Godard C (2017) Advances in the
preparation of highly selective nanocatalysts for the semi-hydrogenation of alkynes using
colloidal approaches. Dalton Trans 46:12381–12403
28. López-Vinasco AM, Martínez-Prieto LM, Asensio JM, Lecante P, Chaudret B, Cámpora J,
van Leeuwen PWNM (2020) Novel nickel nanoparticles stabilized by imidazolium-amidinate
ligands for selective hydrogenation of alkynes. Catal Sci Tech 10:342–350
29. Fang M, Sánchez-Delgado RA (2014) Ruthenium nanoparticles supported on magnesium
oxide: a versatile and recyclable dual-site catalyst for hydrogenation of mono- and poly-cyclic
arenes, N-heteroaromatics, and S-heteroaromatics. J Catal 311:357–368
30. Rakers L, Martínez-Prieto LM, López-Vinasco AM, Philippot K, van Leeuwen PWNM,
Chaudret B, Glorius F (2018) Ruthenium nanoparticles ligated by cholesterol-derived NHCs
and their application in the hydrogenation of arenes. Chem Commun 54:7070–7073
31. Cano I, Tschan MJL, Martinez-Prieto LM, Philippot K, Chaudret B, van Leeuwen PWNM
(2016) Enantioselective hydrogenation of ketones by iridium nanoparticles ligated with chiral
secondary phosphine oxides. Catal Sci Tech 6:3758–3766
32. Martinez-Prieto LM, Ferry A, Rakers L, Richter C, Lecante P, Philippot K, Chaudret B,
Glorius F (2016) Long-chain NHC-stabilized RuNPs as versatile catalysts for one-pot oxidation/hydrogenation reactions. Chem Commun 52:4768–4771
33. Mitsudome T, Yamamoto M, Maeno Z, Mizugaki T, Jitsukawa K, Kaneda K (2015) One-step
synthesis of Core-gold/Shell-ceria nanomaterial and its catalysis for highly selective
Semihydrogenation of alkynes. J Am Chem Soc 137:13452–13455
34. Cano I, Martinez-Prieto LM, Fazzini PF, Coppel Y, Chaudret B, van Leeuwen PWNM (2017)
Characterization of secondary phosphine oxide ligands on the surface of iridium nanoparticles.
Phys Chem Chem Phys 19:21655–21662
35. Wan W, Nie X, Janik MJ, Song C, Guo X (2018) Adsorption, dissociation, and spillover of
hydrogen over Au/TiO2 catalysts: the effects of cluster size and metal–support interaction
from DFT. J Phys Chem C 122:17895–17916
36. Luza L, Rambor CP, Gual A, Alves Fernandes J, Eberhardt D, Dupont J (2017) Revealing
hydrogenation reaction pathways on naked gold nanoparticles. ACS Catal 7:2791–2799
37. Corma A, Serna P (2006) Chemoselective hydrogenation of nitro compounds with supported
gold catalysts. Science 313:332–334
38. Li G, Zeng C, Jin R (2015) Chemoselective hydrogenation of nitrobenzaldehyde to
nitrobenzyl alcohol with unsupported Au nanorod catalysts in water. J Phys Chem C
119:11143–11147
39. Pritchard J, Filonenko GA, van Putten R, Hensen EJM, Pidko EA (2015) Heterogeneous and
homogeneous catalysis for the hydrogenation of carboxylic acid derivatives: history, advances
and future directions. Chem Soc Rev 44:3808–3833
40. Martínez-Prieto LM, Puche M, Cerezo-Navarrete C, Chaudret B (2019) Uniform Ru
nanoparticles on N-doped graphene for selective hydrogenation of fatty acids to alcohols. J
Catal 377:429–437
448
L. M. Martínez-Prieto et al.
approach to improving clinical success. J Med Chem 52:6752–6756
24. García-Antón J, Axet MR, Jansat S, Philippot K, Chaudret B, Pery T, Buntkowsky G,
Limbach HH (2008) Reactions of olefins with ruthenium hydride nanoparticles: NMR characterization, hydride titration, and room-temperature C–C bond activation. Angew Chem Int
Ed 47:2074–2078
25. Hu Y, Yu Y, Hou Z, Li H, Zhao X, Feng B (2008) Biphasic hydrogenation of olefins by
functionalized ionic liquid-stabilized palladium nanoparticles. Adv Synth Catal
350:2077–2085
26. Fiorio JL, López N, Rossi LM (2017) Gold–ligand-catalyzed selective hydrogenation of
alkynes into cis-alkenes via H2 Heterolytic activation by frustrated Lewis Pairs. ACS Catal
7:2973–2980
27. Delgado JA, Benkirane O, Claver C, Curulla-Ferre D, Godard C (2017) Advances in the
preparation of highly selective nanocatalysts for the semi-hydrogenation of alkynes using
colloidal approaches. Dalton Trans 46:12381–12403
28. López-Vinasco AM, Martínez-Prieto LM, Asensio JM, Lecante P, Chaudret B, Cámpora J,
van Leeuwen PWNM (2020) Novel nickel nanoparticles stabilized by imidazolium-amidinate
ligands for selective hydrogenation of alkynes. Catal Sci Tech 10:342–350
29. Fang M, Sánchez-Delgado RA (2014) Ruthenium nanoparticles supported on magnesium
oxide: a versatile and recyclable dual-site catalyst for hydrogenation of mono- and poly-cyclic
arenes, N-heteroaromatics, and S-heteroaromatics. J Catal 311:357–368
30. Rakers L, Martínez-Prieto LM, López-Vinasco AM, Philippot K, van Leeuwen PWNM,
Chaudret B, Glorius F (2018) Ruthenium nanoparticles ligated by cholesterol-derived NHCs
and their application in the hydrogenation of arenes. Chem Commun 54:7070–7073
31. Cano I, Tschan MJL, Martinez-Prieto LM, Philippot K, Chaudret B, van Leeuwen PWNM
(2016) Enantioselective hydrogenation of ketones by iridium nanoparticles ligated with chiral
secondary phosphine oxides. Catal Sci Tech 6:3758–3766
32. Martinez-Prieto LM, Ferry A, Rakers L, Richter C, Lecante P, Philippot K, Chaudret B,
Glorius F (2016) Long-chain NHC-stabilized RuNPs as versatile catalysts for one-pot oxidation/hydrogenation reactions. Chem Commun 52:4768–4771
33. Mitsudome T, Yamamoto M, Maeno Z, Mizugaki T, Jitsukawa K, Kaneda K (2015) One-step
synthesis of Core-gold/Shell-ceria nanomaterial and its catalysis for highly selective
Semihydrogenation of alkynes. J Am Chem Soc 137:13452–13455
34. Cano I, Martinez-Prieto LM, Fazzini PF, Coppel Y, Chaudret B, van Leeuwen PWNM (2017)
Characterization of secondary phosphine oxide ligands on the surface of iridium nanoparticles.
Phys Chem Chem Phys 19:21655–21662
35. Wan W, Nie X, Janik MJ, Song C, Guo X (2018) Adsorption, dissociation, and spillover of
hydrogen over Au/TiO2 catalysts: the effects of cluster size and metal–support interaction
from DFT. J Phys Chem C 122:17895–17916
36. Luza L, Rambor CP, Gual A, Alves Fernandes J, Eberhardt D, Dupont J (2017) Revealing
hydrogenation reaction pathways on naked gold nanoparticles. ACS Catal 7:2791–2799
37. Corma A, Serna P (2006) Chemoselective hydrogenation of nitro compounds with supported
gold catalysts. Science 313:332–334
38. Li G, Zeng C, Jin R (2015) Chemoselective hydrogenation of nitrobenzaldehyde to
nitrobenzyl alcohol with unsupported Au nanorod catalysts in water. J Phys Chem C
119:11143–11147
39. Pritchard J, Filonenko GA, van Putten R, Hensen EJM, Pidko EA (2015) Heterogeneous and
homogeneous catalysis for the hydrogenation of carboxylic acid derivatives: history, advances
and future directions. Chem Soc Rev 44:3808–3833
40. Martínez-Prieto LM, Puche M, Cerezo-Navarrete C, Chaudret B (2019) Uniform Ru
nanoparticles on N-doped graphene for selective hydrogenation of fatty acids to alcohols. J
Catal 377:429–437
448
L. M. Martínez-Prieto et al.