Nowadays, the field of HT has a solid and proven mechanistic basis that allows
for the design, development and optimization of new catalytic systems to tackle new
issues, fulfilling efficiency and sustainability criteria, with a high possibility of
success.
In summary, TH affords an effective alternative for the reduction of unsaturated
substrates, and the last 5 years has witnessed great efforts to develop iridium
catalysts for this purpose. In particular, iridium catalysts have substantially contributed to the development of green and sustainable as well as new anticancer strategies
associated with TH processes. Without a doubt, in the coming years, in this rapidly
evolving area, there will be interesting findings for both academia and industry.
References
1. Meervein H, Schmidt R (1925) Liebigs Ann Chem 444:221–238
2. Verley A (1925) Bull Soc Chim Fr 37:537–542
3. Ponndorf W (1926) Angew Chem 39:138–143
4. Addadh YMY, Henbest HB, Husbands J, Mitchell TRB (1964) Proc Chem Soc Lond:361
5. Trocha-Grimshaw J, Henbest HB (1967) Chem Commun:544
6. Sasson Y, Blum J (1971) Tetrahedron Lett 12:2167–2170
7. Sasson Y, Blum J (1975) J Org Chem 40:1887–1896
8. Blum J, Sasson Y, Iflah S (1972) Tetrahedron Lett 13:1015–1018
9. Chowdhury RL, Bäckvall JE (1991) J Chem Soc Chem Commun:1063–1064
10. Hashiguchi S, Fujii A, Takehara J, Ikariya T, Noyori R (1995) J Am Chem Soc
117:7562–7563
11. Noyori R, Yamakawa M, Hashiguchi S (2001) J Org Chem 66:7931–7944
12. Li YY, Yu SL, Shen WY, Gao JX (2015) Acc Chem Res 48:2587–2598
13. Magubane MN, Nyamato GS, Ojwach SO, Munro OQ (2016) RSC Adv 6:65205–65221
14. Dubey P, Gupta S, Singh AK (2019) Organometallics 38:944–961
15. Shaikh MN (2019) RSC Adv 9:28199–28206
16. Foubelo F, Nájera C, Yus M (2015) Tetrahedron Asymmetry 26:769–790
17. Chelucci G, Baldino S, Baratta W (2015) Acc Chem Res 48:363–379
18. Gichumbi JM, Friedrich HB (2018) 866:123–143
19. Wang F, Lin Xu L, Sun C, Yu L, Xu Q (2018) Appl Organometal Chem 32:e4505
20. Tang Z, Liu P, Cao H, Bals S, Heeres HJ, Pescarmona PP (2019) ACS Catal 9:9953–9963
21. Vilhanová B, van Bokhoven JA, Ranocchiaric M (2017) Adv Synth Catal 359:677–686
22. Zhao J, Li Q, Zhuang S, Song Y, Morris DJ, Zhou M, Wu Z, Zhang P, Jin R (2018) J Phys
Chem Lett 9:7173–7179
23. Hou SF, Chen JY, Xue M, Jia M, Zhai X, Liao RZ, Tung CH, Wang W (2020) ACS Catal
10:380–390
24. Wu W, Seki T, Walker KL, Waymouth RM (2018) Organometallics 37:1428–1431
25. Ma F, Chen J, Yang F, Shinde MV, Zhoua Y, Fan B (2017) Org Biomol Chem 15:2359–2362
26. Xu Y, Long J, Zhao W, Li H, Yang S (2019) Front Chem 7:590
27. Mishra AA, Bhanage BM (2019) New J Chem 43:6160–6167
28. Cabanillas M, Franco A, Lázaro N, Balu AM, Luque R, Pineda A (2019) Mol Catal
477:110522
29. Wang F, Planas O, Cornella J (2019) J Am Chem Soc 141:4235–4240
30. Bolm C (2009) Nat Chem 1:420–420
31. Bullock RM (2013) Science 342:1054–1055
32. Zuo WW, Lough AJ, Li YF, Morris RH (2013) Science 342:1080–1083
146
M. Pilar Lamata et al.
for the design, development and optimization of new catalytic systems to tackle new
issues, fulfilling efficiency and sustainability criteria, with a high possibility of
success.
In summary, TH affords an effective alternative for the reduction of unsaturated
substrates, and the last 5 years has witnessed great efforts to develop iridium
catalysts for this purpose. In particular, iridium catalysts have substantially contributed to the development of green and sustainable as well as new anticancer strategies
associated with TH processes. Without a doubt, in the coming years, in this rapidly
evolving area, there will be interesting findings for both academia and industry.
References
1. Meervein H, Schmidt R (1925) Liebigs Ann Chem 444:221–238
2. Verley A (1925) Bull Soc Chim Fr 37:537–542
3. Ponndorf W (1926) Angew Chem 39:138–143
4. Addadh YMY, Henbest HB, Husbands J, Mitchell TRB (1964) Proc Chem Soc Lond:361
5. Trocha-Grimshaw J, Henbest HB (1967) Chem Commun:544
6. Sasson Y, Blum J (1971) Tetrahedron Lett 12:2167–2170
7. Sasson Y, Blum J (1975) J Org Chem 40:1887–1896
8. Blum J, Sasson Y, Iflah S (1972) Tetrahedron Lett 13:1015–1018
9. Chowdhury RL, Bäckvall JE (1991) J Chem Soc Chem Commun:1063–1064
10. Hashiguchi S, Fujii A, Takehara J, Ikariya T, Noyori R (1995) J Am Chem Soc
117:7562–7563
11. Noyori R, Yamakawa M, Hashiguchi S (2001) J Org Chem 66:7931–7944
12. Li YY, Yu SL, Shen WY, Gao JX (2015) Acc Chem Res 48:2587–2598
13. Magubane MN, Nyamato GS, Ojwach SO, Munro OQ (2016) RSC Adv 6:65205–65221
14. Dubey P, Gupta S, Singh AK (2019) Organometallics 38:944–961
15. Shaikh MN (2019) RSC Adv 9:28199–28206
16. Foubelo F, Nájera C, Yus M (2015) Tetrahedron Asymmetry 26:769–790
17. Chelucci G, Baldino S, Baratta W (2015) Acc Chem Res 48:363–379
18. Gichumbi JM, Friedrich HB (2018) 866:123–143
19. Wang F, Lin Xu L, Sun C, Yu L, Xu Q (2018) Appl Organometal Chem 32:e4505
20. Tang Z, Liu P, Cao H, Bals S, Heeres HJ, Pescarmona PP (2019) ACS Catal 9:9953–9963
21. Vilhanová B, van Bokhoven JA, Ranocchiaric M (2017) Adv Synth Catal 359:677–686
22. Zhao J, Li Q, Zhuang S, Song Y, Morris DJ, Zhou M, Wu Z, Zhang P, Jin R (2018) J Phys
Chem Lett 9:7173–7179
23. Hou SF, Chen JY, Xue M, Jia M, Zhai X, Liao RZ, Tung CH, Wang W (2020) ACS Catal
10:380–390
24. Wu W, Seki T, Walker KL, Waymouth RM (2018) Organometallics 37:1428–1431
25. Ma F, Chen J, Yang F, Shinde MV, Zhoua Y, Fan B (2017) Org Biomol Chem 15:2359–2362
26. Xu Y, Long J, Zhao W, Li H, Yang S (2019) Front Chem 7:590
27. Mishra AA, Bhanage BM (2019) New J Chem 43:6160–6167
28. Cabanillas M, Franco A, Lázaro N, Balu AM, Luque R, Pineda A (2019) Mol Catal
477:110522
29. Wang F, Planas O, Cornella J (2019) J Am Chem Soc 141:4235–4240
30. Bolm C (2009) Nat Chem 1:420–420
31. Bullock RM (2013) Science 342:1054–1055
32. Zuo WW, Lough AJ, Li YF, Morris RH (2013) Science 342:1080–1083
146
M. Pilar Lamata et al.