Solati Z, Baharin BS, Bagheri H (2014) Antioxidant property, thymoquinone content and chemical
characteristics of different extracts from Nigella sativa L. seeds. J Am Oil Chem Soc 91
(2):295–300
Srinivasan K (2018) Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Qual Saf 2(1):1–6
Suguna P, Geetha A, Aruna R, Siva GV (2013) Effect of thymoquinone on ethanol and high fat diet
induced chronic pancreatitis—a dose response study in rats. Indian J Exp Biol 51(4):292–302
Sultan MT, Butt MS, Anjum FM, Jamil A, Akhtar S, Nasir M (2009) Nutritional profile of
indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential
oil. Pak J Bot 41(3):1321–1330
Sunita M, Meenakshi S (2013) Chemical composition and antidermatophytic activity of Nigella
sativa essential oil. Afr J Pharm Pharmacol 7(20):1286–1292
Swamy SM, Tan BK (2000) Cytotoxic and immunopotentiating effects of ethanolic extract of
Nigella sativa L. seeds. J Ethnopharmacol 70(1):1–7
Takruri HR, Dameh MA (1998) Study of the nutritional value of black cumin seeds (Nigella
sativaL). J Sci Food Agric 76(3):404–410
Taşkin MK, ÇALIŞKAN ÖA, Anil H, Abou-Gazar H, Khan IA, BEDİR E (2005) Triterpene
saponins from Nigella sativa L. Turk J Chem 29(5):561–569
Tayman C, Cekmez F, Kafa IM, Canpolat FE, Cetinkaya M, Uysal S, Tunc T, Sarıcı SU (2012)
Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis. J
Investig Surg 25(5):286–294
Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK (2010) Effects
of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the
development of novel cancer therapies. Mol Cancer Ther 27:1535–7163
Ulu R, Dogukan A, Tuzcu M, Gencoglu H, Ulas M, İlhan N, Muqbil I, Mohammad RM, Kucuk O,
Sahin K (2012) Regulation of renal organic anion and cation transporters by thymoquinone in
cisplatin induced kidney injury. Food Chem Toxicol 50(5):1675–1679
Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA (2012) Modulation of the oxidative
stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in
Wistar rats. Chem Biol Interact 197(1):40–46
Vatansev H, Ciftci H, Ozkaya A, Ozturk B, Evliyaoglu N, Kiyici A (2013) Chemical composition
of Nigella sativa L. seeds used as a medical aromatic plant from East Anatolia Region, Turkey.
Asian J Chem 25(10):5490–5492
Wang T, Hicks KB, Moreau R (2002) Antioxidant activity of phytosterols, oryzanol, and other
phytosterol conjugates. Journal of the American Oil Chemists’ Society 79(12):1201–1206
Wienkötter N, Höpner D, Schütte U, Bauer K, Begrow F, El-Dakhakhny M, Verspohl EJ (2008).
The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary
clearance. Planta medica, 74(02):105-108
Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH (2011) Anticancer activity of
thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochem
Pharmacol 82(5):464–475
Yaman İ, Balikci E (2010) Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol 62(2):183–190
Yarnell E, Abascal K (2011) Nigella sativa: holy herb of the middle East. Altern Comp Ther 17
(2):99–105
Ying Q, Wojciechowska P, Siger A, Kaczmarek A, Rudzinska M (2018) Phytochemical content,
oxidative stability, and nutritional properties of unconventional cold-pressed edible oils. J Food
Nutr Res 6:476–485
350
P. Sharma and T. Longvah
characteristics of different extracts from Nigella sativa L. seeds. J Am Oil Chem Soc 91
(2):295–300
Srinivasan K (2018) Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Qual Saf 2(1):1–6
Suguna P, Geetha A, Aruna R, Siva GV (2013) Effect of thymoquinone on ethanol and high fat diet
induced chronic pancreatitis—a dose response study in rats. Indian J Exp Biol 51(4):292–302
Sultan MT, Butt MS, Anjum FM, Jamil A, Akhtar S, Nasir M (2009) Nutritional profile of
indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential
oil. Pak J Bot 41(3):1321–1330
Sunita M, Meenakshi S (2013) Chemical composition and antidermatophytic activity of Nigella
sativa essential oil. Afr J Pharm Pharmacol 7(20):1286–1292
Swamy SM, Tan BK (2000) Cytotoxic and immunopotentiating effects of ethanolic extract of
Nigella sativa L. seeds. J Ethnopharmacol 70(1):1–7
Takruri HR, Dameh MA (1998) Study of the nutritional value of black cumin seeds (Nigella
sativaL). J Sci Food Agric 76(3):404–410
Taşkin MK, ÇALIŞKAN ÖA, Anil H, Abou-Gazar H, Khan IA, BEDİR E (2005) Triterpene
saponins from Nigella sativa L. Turk J Chem 29(5):561–569
Tayman C, Cekmez F, Kafa IM, Canpolat FE, Cetinkaya M, Uysal S, Tunc T, Sarıcı SU (2012)
Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis. J
Investig Surg 25(5):286–294
Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK (2010) Effects
of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the
development of novel cancer therapies. Mol Cancer Ther 27:1535–7163
Ulu R, Dogukan A, Tuzcu M, Gencoglu H, Ulas M, İlhan N, Muqbil I, Mohammad RM, Kucuk O,
Sahin K (2012) Regulation of renal organic anion and cation transporters by thymoquinone in
cisplatin induced kidney injury. Food Chem Toxicol 50(5):1675–1679
Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA (2012) Modulation of the oxidative
stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in
Wistar rats. Chem Biol Interact 197(1):40–46
Vatansev H, Ciftci H, Ozkaya A, Ozturk B, Evliyaoglu N, Kiyici A (2013) Chemical composition
of Nigella sativa L. seeds used as a medical aromatic plant from East Anatolia Region, Turkey.
Asian J Chem 25(10):5490–5492
Wang T, Hicks KB, Moreau R (2002) Antioxidant activity of phytosterols, oryzanol, and other
phytosterol conjugates. Journal of the American Oil Chemists’ Society 79(12):1201–1206
Wienkötter N, Höpner D, Schütte U, Bauer K, Begrow F, El-Dakhakhny M, Verspohl EJ (2008).
The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary
clearance. Planta medica, 74(02):105-108
Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH (2011) Anticancer activity of
thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochem
Pharmacol 82(5):464–475
Yaman İ, Balikci E (2010) Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol 62(2):183–190
Yarnell E, Abascal K (2011) Nigella sativa: holy herb of the middle East. Altern Comp Ther 17
(2):99–105
Ying Q, Wojciechowska P, Siger A, Kaczmarek A, Rudzinska M (2018) Phytochemical content,
oxidative stability, and nutritional properties of unconventional cold-pressed edible oils. J Food
Nutr Res 6:476–485
350
P. Sharma and T. Longvah