Table 1.3
(continued)
Experimental model
The form of soya bean
Dose and route of
administration
Investigation
Major
finding/s
Reference
Prostate cancer cells
(PC3 and DU145)
D-Pinitol
(0, 1, 3, 10, and 30
μM) for
24 h,
Assay of cell viability,
TUNEL, caspase 3 activity,
migration and invasion, and
wound-healing migration
Reduced metastatic
activity of human
prostate cancer cells
Lin et al.
(2013)
C57BL/6
 FVB F
1
TRAMP male pups
Soy isoflavone
–
Assay of hepatic aromatase
and 5α-reductase; expression
of AR, AR-regulated genes,
FOXA1, UGT weight, and
tumor progression; and
upregulated protective
FOXO3
Chemopreventive
Christensen
et al. (2013)
Transgenic adenocarcinoma of the mouse
prostate (TRAMP)
model
Soy germ powder and
tomato powder
2% soy germ (SG) powder or
10% tomato powder with 2%
soy germ powder (TP + SG)
for 14 weeks
Assay of isoflavone and
carotenoid analysis in serum,
prostate, and tissues
Prostate cancerpreventive effect
Zuniga et al.
(2013)
LNCaP and C4-2B
cells
Cooked and in vitro
digested soy extracts
500,1000, and 2000
μg/mL
Apoptosis and cytotoxicity
assays
Anticancer effect
Dong et al.
(2012)
BALB/c mice
(4T1 breast tumor
model)
Soy isoflavone
100 mg/kg diet
Analysis of NF-κBp65
0
vascular endothelial growth factor
receptor 2 (VEGFR2) and Pgp
gene and protein expressions
Anticarcinogenic
effects
Hejazi et al.
(2017)
16
R. Modgil et al.