Human (DM patients) Soy protein isolate (SPI) 80 mg/d for 57 d
Assay of lipid metabolism
parameters
Hypolipidemic and
cardioprotective
effect
Pipe et al.
(2009)
Human
Soy protein isolate (SPI) Low-isoflavone SPI
(1.64
Æ 0.19 mg/d) and highisoflavone SPI
(61.7
Æ 7.4 mg/d) for 57 d
Assay of lipid metabolism
parameters
Hypolipidemic and
cardioprotective
effect
McVeigh
et al. (2006)
Human
(hyperlipidemic and
diabetic patients)
Soya bean dietary
supplement
D-LeciVita (12% lecithin,
35% soy protein) 15 g/d for
12 weeks
Assay of blood glucose, lipid
metabolism parameters
Hypolipidemic and
cardioprotective
effect
Medić et al.
(2006)
Human (men and
Postmenopausal
women)
Soy protein isolate (SPI) SPI (40 g soy protein, 118 mg
isoflavones)/d for 3 months
Assay of blood pressure and
lipid metabolism parameters
Improvement in
blood pressure and
hypolipidemic effect
Liang et al.
(2006)
Human
(hyperlipidemic)
Soybean product diet
2%/d for 4 weeks
Assay of blood pressure and
lipid metabolism parameters
Hypolipidemic and
cardioprotective
effect
Kurowska
et al. (1997)
Human (hypercholesterolemic renal transplant recipients)
Soy protein diet
25 g soy protein/day for
5 week
Assay of blood lipid metabolism parameters
Hypolipidemic
Cupisti et al.
(2004)
Human (obese)
Soy-based low-calorie
diet
Soy protein (only protein
source) for 8 weeks
Assay of weight control, body
composition, and blood lipid
profile
Weight and body fat
reduction along with
hypolipidemic effect
Liao et al.
(2007)
Human
(hypercholesterolemic)
Isolated soy protein
(ISP)
30–50 g ISP and 10–16.6 g
cotyledon
fiber/d for 16 weeks
Assay of lipid, lipoprotein,
and homocysteine
concentrations
Hypolipidemic and
antiatherosclerotic
effect
Tonstad
et al. (2002)
Human
(postmenopausal)
Soy protein isolate (SPI) SPI (40 g/d) for 6 weeks
Assay of weight control, body
composition, and blood lipid
profile
Hypolipidemic and
cardioprotective
effect
Hanson
et al. (2006)
Human (diabetics)
Soy nut diet
60 g/d for 8 weeks
Assay of blood glucose, lipid
parameters, and antioxidant
enzymes
Hypolipidemic,
hypoglycemic, and
cardioprotective
effect
Sedaghat
et al. (2019)
(continued)
1 Soybean (Glycine max)
1 3
Assay of lipid metabolism
parameters
Hypolipidemic and
cardioprotective
effect
Pipe et al.
(2009)
Human
Soy protein isolate (SPI) Low-isoflavone SPI
(1.64
Æ 0.19 mg/d) and highisoflavone SPI
(61.7
Æ 7.4 mg/d) for 57 d
Assay of lipid metabolism
parameters
Hypolipidemic and
cardioprotective
effect
McVeigh
et al. (2006)
Human
(hyperlipidemic and
diabetic patients)
Soya bean dietary
supplement
D-LeciVita (12% lecithin,
35% soy protein) 15 g/d for
12 weeks
Assay of blood glucose, lipid
metabolism parameters
Hypolipidemic and
cardioprotective
effect
Medić et al.
(2006)
Human (men and
Postmenopausal
women)
Soy protein isolate (SPI) SPI (40 g soy protein, 118 mg
isoflavones)/d for 3 months
Assay of blood pressure and
lipid metabolism parameters
Improvement in
blood pressure and
hypolipidemic effect
Liang et al.
(2006)
Human
(hyperlipidemic)
Soybean product diet
2%/d for 4 weeks
Assay of blood pressure and
lipid metabolism parameters
Hypolipidemic and
cardioprotective
effect
Kurowska
et al. (1997)
Human (hypercholesterolemic renal transplant recipients)
Soy protein diet
25 g soy protein/day for
5 week
Assay of blood lipid metabolism parameters
Hypolipidemic
Cupisti et al.
(2004)
Human (obese)
Soy-based low-calorie
diet
Soy protein (only protein
source) for 8 weeks
Assay of weight control, body
composition, and blood lipid
profile
Weight and body fat
reduction along with
hypolipidemic effect
Liao et al.
(2007)
Human
(hypercholesterolemic)
Isolated soy protein
(ISP)
30–50 g ISP and 10–16.6 g
cotyledon
fiber/d for 16 weeks
Assay of lipid, lipoprotein,
and homocysteine
concentrations
Hypolipidemic and
antiatherosclerotic
effect
Tonstad
et al. (2002)
Human
(postmenopausal)
Soy protein isolate (SPI) SPI (40 g/d) for 6 weeks
Assay of weight control, body
composition, and blood lipid
profile
Hypolipidemic and
cardioprotective
effect
Hanson
et al. (2006)
Human (diabetics)
Soy nut diet
60 g/d for 8 weeks
Assay of blood glucose, lipid
parameters, and antioxidant
enzymes
Hypolipidemic,
hypoglycemic, and
cardioprotective
effect
Sedaghat
et al. (2019)
(continued)
1 Soybean (Glycine max)
1 3