50
L. Quadro and E. K. Spiegler
Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen
DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia
F (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:6302
Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ (2003)
Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and
most of the heterozygotes die in utero. Proc Natl Acad Sci USA 100:6358–6363
Clagett-Dame M, Knutson D (2011) Vitamin A in reproduction and development. Nutrients
2011(3):385–428
Collins MD, Tzimas G, Hummler H, Burgin H, Nau H (1994) Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate
following daily administrations in rats. Toxicol Appl Pharmacol 127:132–144
Collins MD, Tzimas G, Burgin H, Hummler H, Nau H (1995) Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental
kinetics in rat and rabbit. Toxicol Appl Pharmacol 130:9–18
Costabile BK, Kim YK, Iqbal J, Zuccaro MV, Wassef L, Narayanasamy S, Curley RW Jr, Harrison
EH, Hussain MM, Quadro L (2016) Beta-Apo-10 -carotenoids modulate placental microsomal
triglyceride transfer protein expression and function to optimize transport of intact beta-carotene
to the embryo. J Biol Chem 291:18525–18535
Creech Kraft J, Lofberg B, Chahoud I, Bochert G, Nau H (1989) Teratogenicity and placental transfer
of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low
oral dose during organogenesis in mice. Toxicol Appl Pharmacol 1989(100):162–176
Cross JC (2006) Placental function in development and disease. Reprod Fertil Dev 18:71–76
Dann WJ (1934a) The transmission of vitamin A from parents to young in mammals: effect of the
fat content of diet during pregnancy on the transmission of vitamin A to the foetal rat. Biochem
J 28:634–637
Dann WJ (1934b) The transmission of vitamin A from parents to young in mammals: effect of
the liver reserves of the mother on the transmission of vitamin A to the foetal and suckling rat.
Biochem J 28:2141–2146
Dimenstein R, Trugo NM, Donangelo CM, Trugo LC, Anastacio AS (1996) Effect of subadquate
maternal vitamin A status on placental transfer of retinol and b-carotene to the human fetus. Biol
Neonate 69:230–234
Dixon JL, Kim YK, Brinker A, Quadro L (2014) Loss of beta-carotene 15,15 -oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys
Acta 1841:34–43
Donoghue S, Richardson DW, Sklan D, Kronfeld DS (1982) Placental transport of retinol in sheep.
J Nutr 112:2197–2203
Eckhoff C, Chari S, Kromka M, Staudner H, Juhasz L, Rudiger H, Agnish N (1994) Teratogenicity
and transplacental pharmacokinetics of 13-cis-retinoic acid in rabbits. Toxicol Appl Pharmacol
125:34–41
Erdman JW Jr, Bierer TL, Gugger ET (1993) Absorption and transport of carotenoids. Ann NY
Acad Sci 691:76–85
Eroglu A, Hruszkewycz DP, Curley RW Jr, Harrison EH (2010) The eccentric cleavage product of
beta-carotene, beta-apo-13-carotenone, functions as an antagonist of RXRalpha. Arch Biochem
Biophys 504:11–16
Eroglu A, Hruszkewycz DP, Dela Sena C, Narayanasamy S, Riedl KM, Kopec RE, Schwartz SJ,
Curley RW Jr, Harrison EH (2012) Naturally occurring eccentric cleavage products of provitamin
a beta-carotene function as antagonists of retinoic acid receptors. J Biol Chem 287:15886–15895
Farese RV Jr, Ruland SL, Flynn LM, Stokowski RP, Young SG (1995) Knockout of the mouse
apolipoprotein B gene results in embryonic lethality in homozygotes and protection against
diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci USA 92:1774–1778
Farese RV Jr, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL (1996) A novel
function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal
lipid transport in mice. J Lipid Res 37:347–360
L. Quadro and E. K. Spiegler
Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen
DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia
F (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:6302
Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ (2003)
Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and
most of the heterozygotes die in utero. Proc Natl Acad Sci USA 100:6358–6363
Clagett-Dame M, Knutson D (2011) Vitamin A in reproduction and development. Nutrients
2011(3):385–428
Collins MD, Tzimas G, Hummler H, Burgin H, Nau H (1994) Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate
following daily administrations in rats. Toxicol Appl Pharmacol 127:132–144
Collins MD, Tzimas G, Burgin H, Hummler H, Nau H (1995) Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental
kinetics in rat and rabbit. Toxicol Appl Pharmacol 130:9–18
Costabile BK, Kim YK, Iqbal J, Zuccaro MV, Wassef L, Narayanasamy S, Curley RW Jr, Harrison
EH, Hussain MM, Quadro L (2016) Beta-Apo-10 -carotenoids modulate placental microsomal
triglyceride transfer protein expression and function to optimize transport of intact beta-carotene
to the embryo. J Biol Chem 291:18525–18535
Creech Kraft J, Lofberg B, Chahoud I, Bochert G, Nau H (1989) Teratogenicity and placental transfer
of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low
oral dose during organogenesis in mice. Toxicol Appl Pharmacol 1989(100):162–176
Cross JC (2006) Placental function in development and disease. Reprod Fertil Dev 18:71–76
Dann WJ (1934a) The transmission of vitamin A from parents to young in mammals: effect of the
fat content of diet during pregnancy on the transmission of vitamin A to the foetal rat. Biochem
J 28:634–637
Dann WJ (1934b) The transmission of vitamin A from parents to young in mammals: effect of
the liver reserves of the mother on the transmission of vitamin A to the foetal and suckling rat.
Biochem J 28:2141–2146
Dimenstein R, Trugo NM, Donangelo CM, Trugo LC, Anastacio AS (1996) Effect of subadquate
maternal vitamin A status on placental transfer of retinol and b-carotene to the human fetus. Biol
Neonate 69:230–234
Dixon JL, Kim YK, Brinker A, Quadro L (2014) Loss of beta-carotene 15,15 -oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys
Acta 1841:34–43
Donoghue S, Richardson DW, Sklan D, Kronfeld DS (1982) Placental transport of retinol in sheep.
J Nutr 112:2197–2203
Eckhoff C, Chari S, Kromka M, Staudner H, Juhasz L, Rudiger H, Agnish N (1994) Teratogenicity
and transplacental pharmacokinetics of 13-cis-retinoic acid in rabbits. Toxicol Appl Pharmacol
125:34–41
Erdman JW Jr, Bierer TL, Gugger ET (1993) Absorption and transport of carotenoids. Ann NY
Acad Sci 691:76–85
Eroglu A, Hruszkewycz DP, Curley RW Jr, Harrison EH (2010) The eccentric cleavage product of
beta-carotene, beta-apo-13-carotenone, functions as an antagonist of RXRalpha. Arch Biochem
Biophys 504:11–16
Eroglu A, Hruszkewycz DP, Dela Sena C, Narayanasamy S, Riedl KM, Kopec RE, Schwartz SJ,
Curley RW Jr, Harrison EH (2012) Naturally occurring eccentric cleavage products of provitamin
a beta-carotene function as antagonists of retinoic acid receptors. J Biol Chem 287:15886–15895
Farese RV Jr, Ruland SL, Flynn LM, Stokowski RP, Young SG (1995) Knockout of the mouse
apolipoprotein B gene results in embryonic lethality in homozygotes and protection against
diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci USA 92:1774–1778
Farese RV Jr, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL (1996) A novel
function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal
lipid transport in mice. J Lipid Res 37:347–360