172
H. A. Marquez and F. Chen
Kaplan NB, Grant MM, Brody JS (1985) The lipid interstitial cell of the pulmonary alveolus. Age
and species differences. Am Rev Respir Dis 132:1307–1312
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H (2007) A membrane
receptor for retinol binding protein mediates cellular uptake of vitamin A. Science (New York,
N.Y.) 315:820–825
Lebeche D, Malpel S, Cardoso WV (1999) Fibroblast growth factor interactions in the developing
lung. Mech Dev 86:125–136
Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C (2008) Bmp4 is required for tracheal formation:
a novel mouse model for tracheal agenesis. Dev Biol 322:145–155
Lindahl P, Karlsson L, Hellstrom M, Gebre-Medhin S, Willetts K, Heath JK, Betsholtz C (1997)
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar
smooth muscle cell progenitors during lung development. Development 124:3943–3953
Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P (1993) Function of retinoic acid
receptor gamma in the mouse. Cell 73:643–658
Luo J, Sucov HM, Bader JA, Evans RM, Giguere V (1996) Compound mutants for retinoic acid
receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta
isoforms. Mech Dev 55:33–44
MacLean G, Abu-Abed S, Dolle P, Tahayato A, Chambon P, Petkovich M (2001) Cloning of a novel
retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with
Cyp26A1 during early murine development. Mech Dev 107:195–201
Maina JN (2006) Development, structure, and function of a novel respiratory organ, the lung-air sac
system of birds: to go where no other vertebrate has gone. Biol Rev Camb Philos Soc 81:545–579
Major D, Cadenas M, Fournier L, Leclerc S, Lefebvre M, Cloutier R (1998) Retinol status of
newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 13:547–549
Malpel S, Mendelsohn C, Cardoso WV (2000) Regulation of retinoic acid signaling during lung
morphogenesis. Development 127:3057–3067
Marquez HA, Cardoso WV (2016) Vitamin A-retinoid signaling in pulmonary development and
disease. Mol Cell Pediatr 3:28
Massaro GD, Massaro D, Chambon P (2003) Retinoic acid receptor-alpha regulates pulmonary
alveolus formation in mice after, but not during, perinatal period. Am J Physiol Lung Cell Mol
Physiol 284:L431-433
Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P, Chandraratna RA (2000)
Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary
alveoli. Physiol Genomics 4:51–57
McCollum EV, Davis M (1913) The necessity of certain lipins in the diet during growth. J Biol
Chem 15:167–175
McGowan S, Jackson SK, Jenkins-Moore M, Dai HH, Chambon P, Snyder JM (2000) Mice bearing
deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. Am
J Respir Cell Mol Biol 23:162–167
McGowan SE, Doro MM, Jackson SK (1997) Endogenous retinoids increase perinatal elastin gene
expression in rat lung fibroblasts and fetal explants. Am J Physiol 273:L410-416
Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M (1994) Function
of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various
stages of organogenesis in RAR double mutants. Development 120:2749–2771
Metzger RJ, Klein OD, Martin GR, Krasnow MA (2008) The branching programme of mouse lung
development. Nature 453:745–750
Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS (1998)
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity
to Drosophila branchless. Genes Dev 12:3156–3161
Mollard R, Ghyselinck NB, Wendling O, Chambon P, Mark M (2000) Stage-dependent responses
of the developing lung to retinoic acid signaling. Int J Dev Biol 44:457–462
Moura RS (2019) Retinoic acid as a modulator of proximal-distal patterning and branching
morphogenesis of the avian lung. In: Methods in molecular biology. Clifton, N.J., pp 209–224.
H. A. Marquez and F. Chen
Kaplan NB, Grant MM, Brody JS (1985) The lipid interstitial cell of the pulmonary alveolus. Age
and species differences. Am Rev Respir Dis 132:1307–1312
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H (2007) A membrane
receptor for retinol binding protein mediates cellular uptake of vitamin A. Science (New York,
N.Y.) 315:820–825
Lebeche D, Malpel S, Cardoso WV (1999) Fibroblast growth factor interactions in the developing
lung. Mech Dev 86:125–136
Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C (2008) Bmp4 is required for tracheal formation:
a novel mouse model for tracheal agenesis. Dev Biol 322:145–155
Lindahl P, Karlsson L, Hellstrom M, Gebre-Medhin S, Willetts K, Heath JK, Betsholtz C (1997)
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar
smooth muscle cell progenitors during lung development. Development 124:3943–3953
Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P (1993) Function of retinoic acid
receptor gamma in the mouse. Cell 73:643–658
Luo J, Sucov HM, Bader JA, Evans RM, Giguere V (1996) Compound mutants for retinoic acid
receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta
isoforms. Mech Dev 55:33–44
MacLean G, Abu-Abed S, Dolle P, Tahayato A, Chambon P, Petkovich M (2001) Cloning of a novel
retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with
Cyp26A1 during early murine development. Mech Dev 107:195–201
Maina JN (2006) Development, structure, and function of a novel respiratory organ, the lung-air sac
system of birds: to go where no other vertebrate has gone. Biol Rev Camb Philos Soc 81:545–579
Major D, Cadenas M, Fournier L, Leclerc S, Lefebvre M, Cloutier R (1998) Retinol status of
newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 13:547–549
Malpel S, Mendelsohn C, Cardoso WV (2000) Regulation of retinoic acid signaling during lung
morphogenesis. Development 127:3057–3067
Marquez HA, Cardoso WV (2016) Vitamin A-retinoid signaling in pulmonary development and
disease. Mol Cell Pediatr 3:28
Massaro GD, Massaro D, Chambon P (2003) Retinoic acid receptor-alpha regulates pulmonary
alveolus formation in mice after, but not during, perinatal period. Am J Physiol Lung Cell Mol
Physiol 284:L431-433
Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P, Chandraratna RA (2000)
Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary
alveoli. Physiol Genomics 4:51–57
McCollum EV, Davis M (1913) The necessity of certain lipins in the diet during growth. J Biol
Chem 15:167–175
McGowan S, Jackson SK, Jenkins-Moore M, Dai HH, Chambon P, Snyder JM (2000) Mice bearing
deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. Am
J Respir Cell Mol Biol 23:162–167
McGowan SE, Doro MM, Jackson SK (1997) Endogenous retinoids increase perinatal elastin gene
expression in rat lung fibroblasts and fetal explants. Am J Physiol 273:L410-416
Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M (1994) Function
of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various
stages of organogenesis in RAR double mutants. Development 120:2749–2771
Metzger RJ, Klein OD, Martin GR, Krasnow MA (2008) The branching programme of mouse lung
development. Nature 453:745–750
Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS (1998)
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity
to Drosophila branchless. Genes Dev 12:3156–3161
Mollard R, Ghyselinck NB, Wendling O, Chambon P, Mark M (2000) Stage-dependent responses
of the developing lung to retinoic acid signaling. Int J Dev Biol 44:457–462
Moura RS (2019) Retinoic acid as a modulator of proximal-distal patterning and branching
morphogenesis of the avian lung. In: Methods in molecular biology. Clifton, N.J., pp 209–224.