4 RA Signaling in Limb Development and Regeneration …
117
Tickle C, Lee J, Eichele G (1985) A quantitative analysis of the effect of all-trans-retinoic acid on
the pattern of chick wing development. Dev Biol 109:82–95
Uzkudun M, Marcon L, Sharpe J (2015) Data-driven modelling of a gene regulatory network for
cell fate decisions in the growing limb bud. Mol Sys Biol. 11:815
Vandersea MW, Fleming P, McCarthy RA, Smith DG (1998) Fin duplications and deletions induced
by disruptions of retinoic acid signaling. Dev Gene Evol. 208:61–68
Viviano CM, Horton CE, Maden M, Brockes JP (1995) Synthesis and release of 9-cis retinoic acid
by the urodele wound epidermis. Development 1221:3753–3762
Voss SR, Murrugara D, Jensen TB, Monaghan JR (2018) Transcriptional correlates of proximaldistal identity and regeneration timing in axolotl limbs. Comp Biochem Physiol Part C 208:53–63
Wakahara T, Kusu N, Yamauchi H, Kimura I, Konishi M, Miyake A, Itoh N (2007) fibin, a novel
secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. Dev
Biol 303:527–535
Wanek N, Gardiner DM, Muneoka K, Bryant SV (1991) Conversion by retinoic acid of anterior
cells into ZPA cells in the chick wing bud. Nature 350:81–83
Waxman JS, Yelon D (2011) Zebrafish retinoic acid receptors function as context-dependent
transcriptional activators. Dev Biol 352:128–140
White RJ, Nie Q, Lander AD, Schilling TF (2007) Complex regulation of cyp26a1 creates a robust
retinoic acid gradient in the zebrafish embryo. PLoS Biol 5:e304
Wigmore P (1990) Serially duplicated regenerates from the anterior half of the axolotl limb after
retinoic acid treatment. Roux’s Arch Dev Biol 198:252–256
Wilde SM, Wedden SE, Tickle C (1987) Retinoids reprogramme pre-bud mesenchyme to give
changes in limb pattern. Development 100:723–733
Wolpert L (1969) Positional information and the spatial pattern of cellular differentiation. J Theor
Biol 25:1–47
Yakushiji-Kaminatsui N, Kondo T, Hironaka K, Sharif J, Endo TA, Nakayama M, Masui O, Koseki
Y, Kondo K, Ohara O, Vidal M, Morishita Y, Koseki H (2018) Variant PRC1 competes with
retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud. Development
145:dev166348
Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada
H (2004) Regulation of retinoic acid distribution is required for proximodistal patterning and
outgrowth of the developing mouse limb. Dev Cell 6:411–422
Zeller R, López-Ríos J, Zuniga A (2009) Vertebrate limb bud development: moving towards
integrative analysis of organogenesis Nat Rev Gen 10:845–858
Zhao X, Sirbu IO, Mic FA, Molotkova N, Molotkov A, Kumar S, Duester G (2009) Retinoic acid
promotes limb induction through effects on body axis extension but is unnecessary for limb
patterning. Current Biol 19:1050–1057
Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Dräger UC (1996) Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.
Eur J Biochem 240:15–22
117
Tickle C, Lee J, Eichele G (1985) A quantitative analysis of the effect of all-trans-retinoic acid on
the pattern of chick wing development. Dev Biol 109:82–95
Uzkudun M, Marcon L, Sharpe J (2015) Data-driven modelling of a gene regulatory network for
cell fate decisions in the growing limb bud. Mol Sys Biol. 11:815
Vandersea MW, Fleming P, McCarthy RA, Smith DG (1998) Fin duplications and deletions induced
by disruptions of retinoic acid signaling. Dev Gene Evol. 208:61–68
Viviano CM, Horton CE, Maden M, Brockes JP (1995) Synthesis and release of 9-cis retinoic acid
by the urodele wound epidermis. Development 1221:3753–3762
Voss SR, Murrugara D, Jensen TB, Monaghan JR (2018) Transcriptional correlates of proximaldistal identity and regeneration timing in axolotl limbs. Comp Biochem Physiol Part C 208:53–63
Wakahara T, Kusu N, Yamauchi H, Kimura I, Konishi M, Miyake A, Itoh N (2007) fibin, a novel
secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. Dev
Biol 303:527–535
Wanek N, Gardiner DM, Muneoka K, Bryant SV (1991) Conversion by retinoic acid of anterior
cells into ZPA cells in the chick wing bud. Nature 350:81–83
Waxman JS, Yelon D (2011) Zebrafish retinoic acid receptors function as context-dependent
transcriptional activators. Dev Biol 352:128–140
White RJ, Nie Q, Lander AD, Schilling TF (2007) Complex regulation of cyp26a1 creates a robust
retinoic acid gradient in the zebrafish embryo. PLoS Biol 5:e304
Wigmore P (1990) Serially duplicated regenerates from the anterior half of the axolotl limb after
retinoic acid treatment. Roux’s Arch Dev Biol 198:252–256
Wilde SM, Wedden SE, Tickle C (1987) Retinoids reprogramme pre-bud mesenchyme to give
changes in limb pattern. Development 100:723–733
Wolpert L (1969) Positional information and the spatial pattern of cellular differentiation. J Theor
Biol 25:1–47
Yakushiji-Kaminatsui N, Kondo T, Hironaka K, Sharif J, Endo TA, Nakayama M, Masui O, Koseki
Y, Kondo K, Ohara O, Vidal M, Morishita Y, Koseki H (2018) Variant PRC1 competes with
retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud. Development
145:dev166348
Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada
H (2004) Regulation of retinoic acid distribution is required for proximodistal patterning and
outgrowth of the developing mouse limb. Dev Cell 6:411–422
Zeller R, López-Ríos J, Zuniga A (2009) Vertebrate limb bud development: moving towards
integrative analysis of organogenesis Nat Rev Gen 10:845–858
Zhao X, Sirbu IO, Mic FA, Molotkova N, Molotkov A, Kumar S, Duester G (2009) Retinoic acid
promotes limb induction through effects on body axis extension but is unnecessary for limb
patterning. Current Biol 19:1050–1057
Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Dräger UC (1996) Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.
Eur J Biochem 240:15–22