6. Volume of injection using this system is less. Care should be
taken to increase the volume of injection by including multiple
shots for delivering an effective dose of vaccine.
7. Needle-less drug/vaccine delivery involves novel methods for
delivery. The major limitation and point of concern is the
amount of vaccine delivered. The depth of penetration of the
vaccine should not be greater than 300 μm from the skin
surface. Using an array of injectors is a viable option to achieve
maximum vaccine delivery at appropriate depths in the skin.
Acknowledgments
We acknowledge the financial support from Department of Biotechnology (DBT), Ministry of Science and Technology; Department of Science and Technology (DST), Ministry of Science and
Technology; and IMPRINT-II. DC acknowledges DAE for the
SRC Outstanding Investigator award and funds.
References
1. Mitragotri S (2005) Immunization without
needles. Nat Rev Immunol 5:905–916
2. Jagadeesh G, Prakash GD, Rakesh SG, Allam
US, Krishna MG, Eswarappa SM, Chakravortty
D (2011) Needleless vaccine delivery using
micro-shock waves. Clin Vaccine Immunol
18:539–545
3. Chung SW, Hil-lal TA, Byun Y (2012) Strategies for non-invasive delivery of biologics. J
Drug Target 20:481–501
4. Anselmo AC, Gokarn Y, Mitragotri S (2019)
Non-invasive delivery strategies for biologics.
Nat Rev Drug Discov 18:19–40
5. Bareille P, MacSwiney M, Albanese A,
DeVile C, Stanhope R (1997) Growth hormone treatment without a needle using the
Preci-Jet 50 transjector. Arch Dis Child
76:65–67
6. Bremseth DL, Pass F (2001) Delivery of insulin by jet injection: recent observations. Diabetes Technol Ther 3:225–232
7. Petersen J, Jani A (2001) Delivery of erythropoietin with a needleless injection system during hemodialysis maintains plasma levels.
ASAIO J 47:608–610
8. Rogge MC, Charenkavanich S, DiBiase M,
Jones W, Knox SJ, Alam JJ (1998) Impaired
bioavailability of interferon beta-1a when
administered intramuscularly by needle-free
injection. Drug Deliv 5:275–280
9. Jaber A, Bozzato GB, Vedrine L, Prais WA,
Berube J, Laurent PE (2008) A novel needle
for subcutaneous injection of interferon beta1a: effect on pain in volunteers and satisfaction
in patients with multiple sclerosis. BMC
Neurol 8:38
10. Lysakowski C, Dumont L, Tramer MR, Tassonyi E (2003) A needle-free jet-injection system
with lidocaine for peripheral intravenous cannula insertion: a randomized controlled trial
with cost-effectiveness analysis. Anesth Analg
96:215–219, table of contents
11. Bennett J, Nichols F, Rosenblum M, Condry J
(1998) Subcutaneous administration of midazolam: a comparison of the Bioject jet injector
with the conventional syringe and needle. J
Oral Maxillofac Surg 56:1249–1254
12. Domino EF, Zsigmond EK, Kovacs V,
Fekete G, Stetson P (1997) A new route, jet
injection for anesthetic induction in children.
3. Ketamine pharmacokinetic studies. Int J
Clin Pharmacol Ther 35:527–530
13. Subburaj J, Datey A, Gopalan J, Chakravortty
D (2017) Insights into the mechanism of a
novel shockwave-assisted needle-free drug
delivery device driven by in situ-generated oxyhydrogen mixture which provides efficient protection against mycobacterial infections. J Biol
Eng 11:48
14. Baxter J, Mitragotri S (2006) Needle-free liquid jet injections: mechanisms and applications.
Expert Rev Med Devices 3:565–574
15. Koenig HM, Paisansathan C, Albrecht RF 2nd,
Zsigmond EK (2004) Jet injection of local
anesthetic decreases pain of arterial cannulation
Methods of Needle-Free Injections
445
taken to increase the volume of injection by including multiple
shots for delivering an effective dose of vaccine.
7. Needle-less drug/vaccine delivery involves novel methods for
delivery. The major limitation and point of concern is the
amount of vaccine delivered. The depth of penetration of the
vaccine should not be greater than 300 μm from the skin
surface. Using an array of injectors is a viable option to achieve
maximum vaccine delivery at appropriate depths in the skin.
Acknowledgments
We acknowledge the financial support from Department of Biotechnology (DBT), Ministry of Science and Technology; Department of Science and Technology (DST), Ministry of Science and
Technology; and IMPRINT-II. DC acknowledges DAE for the
SRC Outstanding Investigator award and funds.
References
1. Mitragotri S (2005) Immunization without
needles. Nat Rev Immunol 5:905–916
2. Jagadeesh G, Prakash GD, Rakesh SG, Allam
US, Krishna MG, Eswarappa SM, Chakravortty
D (2011) Needleless vaccine delivery using
micro-shock waves. Clin Vaccine Immunol
18:539–545
3. Chung SW, Hil-lal TA, Byun Y (2012) Strategies for non-invasive delivery of biologics. J
Drug Target 20:481–501
4. Anselmo AC, Gokarn Y, Mitragotri S (2019)
Non-invasive delivery strategies for biologics.
Nat Rev Drug Discov 18:19–40
5. Bareille P, MacSwiney M, Albanese A,
DeVile C, Stanhope R (1997) Growth hormone treatment without a needle using the
Preci-Jet 50 transjector. Arch Dis Child
76:65–67
6. Bremseth DL, Pass F (2001) Delivery of insulin by jet injection: recent observations. Diabetes Technol Ther 3:225–232
7. Petersen J, Jani A (2001) Delivery of erythropoietin with a needleless injection system during hemodialysis maintains plasma levels.
ASAIO J 47:608–610
8. Rogge MC, Charenkavanich S, DiBiase M,
Jones W, Knox SJ, Alam JJ (1998) Impaired
bioavailability of interferon beta-1a when
administered intramuscularly by needle-free
injection. Drug Deliv 5:275–280
9. Jaber A, Bozzato GB, Vedrine L, Prais WA,
Berube J, Laurent PE (2008) A novel needle
for subcutaneous injection of interferon beta1a: effect on pain in volunteers and satisfaction
in patients with multiple sclerosis. BMC
Neurol 8:38
10. Lysakowski C, Dumont L, Tramer MR, Tassonyi E (2003) A needle-free jet-injection system
with lidocaine for peripheral intravenous cannula insertion: a randomized controlled trial
with cost-effectiveness analysis. Anesth Analg
96:215–219, table of contents
11. Bennett J, Nichols F, Rosenblum M, Condry J
(1998) Subcutaneous administration of midazolam: a comparison of the Bioject jet injector
with the conventional syringe and needle. J
Oral Maxillofac Surg 56:1249–1254
12. Domino EF, Zsigmond EK, Kovacs V,
Fekete G, Stetson P (1997) A new route, jet
injection for anesthetic induction in children.
3. Ketamine pharmacokinetic studies. Int J
Clin Pharmacol Ther 35:527–530
13. Subburaj J, Datey A, Gopalan J, Chakravortty
D (2017) Insights into the mechanism of a
novel shockwave-assisted needle-free drug
delivery device driven by in situ-generated oxyhydrogen mixture which provides efficient protection against mycobacterial infections. J Biol
Eng 11:48
14. Baxter J, Mitragotri S (2006) Needle-free liquid jet injections: mechanisms and applications.
Expert Rev Med Devices 3:565–574
15. Koenig HM, Paisansathan C, Albrecht RF 2nd,
Zsigmond EK (2004) Jet injection of local
anesthetic decreases pain of arterial cannulation
Methods of Needle-Free Injections
445