194
S. D. Shnyder and C. W. Wright
O
N
47
HN
O
gycine-arginine-NH2
N
H
N
48
HN
N
N
N
49
O
O
N
N
O
N
N
N
50
O
O
N
N
N
N
H
N
51
HN
N
I
F
O
O
HO
O
O
OH
Zn
N
N
N
O
N
O
54
O
Cl
N
H
N
53
HN
N
52
HN
F
Fig. 12 Compounds of interest as potential anticancer agents
the c-kit tyrosine kinase receptor has a G-quadruplex structure, and the consequence
of transcription inhibition was a down-regulation of MEK activity, ERK phosphorylation, and the RAS/MEK/ERK signaling pathway, with a subsequent reduction in
cell survival.
Yuan et al. in 2019 synthesized a series of cryptolepine (1) mimics that demonstrated potent cytotoxicity (IC 50 values in the range 0.31–11.97 μM) against a
panel of four human cancer cell lines (HepG2 hepatoma, T24 bladder, MGC-803
S. D. Shnyder and C. W. Wright
O
N
47
HN
O
gycine-arginine-NH2
N
H
N
48
HN
N
N
N
49
O
O
N
N
O
N
N
N
50
O
O
N
N
N
N
H
N
51
HN
N
I
F
O
O
HO
O
O
OH
Zn
N
N
N
O
N
O
54
O
Cl
N
H
N
53
HN
N
52
HN
F
Fig. 12 Compounds of interest as potential anticancer agents
the c-kit tyrosine kinase receptor has a G-quadruplex structure, and the consequence
of transcription inhibition was a down-regulation of MEK activity, ERK phosphorylation, and the RAS/MEK/ERK signaling pathway, with a subsequent reduction in
cell survival.
Yuan et al. in 2019 synthesized a series of cryptolepine (1) mimics that demonstrated potent cytotoxicity (IC 50 values in the range 0.31–11.97 μM) against a
panel of four human cancer cell lines (HepG2 hepatoma, T24 bladder, MGC-803