174
J. Pospíšil et al.
360. Jenab M, Thompson LU (1996) The influence of flaxseed and lignans on colon carcinogenesis
and β-glucuronidase activity. Carcinogenesis 17:1343
361. Cheng X, Wang H, Yang J, Cheng Y, Wang D, Yang F, Li Y, Zhou D, Wang Y, Xue Z, Zhang
L, Zhang Q, Yang L, Zhang R, Da D (2018) Arctigenin protects against liver injury from
acute hepatitis by suppressing immune cells in mice. Biomed Pharmacother 102:464
362. Li F, Zhang T, Sun H, Gu H, Wang H, Su X, Li C, Li B, Chen R, Kang J (2017) A new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of Schisandra
chinensis. Molecules 22:1931
363. Wang G-W, Deng L-Q, Luo Y-P, Liao Z-H, Chen M (2017) Hepatoprotective triterpenoids
and lignans from the stems of Schisandra pubescens. Nat Prod Res 31:1855
364. Durazzo A, Lucarini M, Souto EB, Cicala C, Caiazzo E, Izzo AA, Novellino E, Santini A
(2019) Polyphenols: a concise overview on the chemistry, occurrence, and human health.
Phytother Res 33:2221
365. Vinson JA (2019) Intracellular polyphenols: how little we know. J Agric Food Chem 67:3865
366. Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O’Brien J, Renwick AG, Korver
O, Smit F, Walker R (2003) Guidance for the safety assessment of botanicals and botanical
preparations for use in food and food supplements. Food Chem Toxicol 41:1625
367. Ross JA, Potter JD, Robison LL (1994) Infant leukemia, topoisomerase II inhibitors, and the
MLL gene. J Natl Cancer Inst 86:1678
368. Lambert JD, Sang S, Yang CS (2007) Possible controversy over dietary polyphenols: benefits
vs risks. Chem Res Toxicol 20:583
369. Konrádová D, Kozubíková H, Doležal K, Pospíšil J (2017) Microwave-assisted synthesis of
phenylpropanoids and coumarins: total synthesis of osthol. Eur J Org Chem 2017:5204
370. Barbušˇ cáková Z, Kozubíková H, Zálešák F, Doležal K, Pospíšil J (2018) General approach to
neolignan-core of the Boehmenan natural product family. Monatsh Chem – Chem Monthly
149:737
371. Grúz J, Pospíšil J, Kozubíková H, Pospíšil T, Doležal K, Bunzel M, Strnad M (2015) Determination of free diferulic, disinapic and dicoumaric acids in plants and foods. Food Chem
171:280
372. Pospíšil J (2020) 1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one. In: Encyclopedia of
reagents for organic synthesis. Wiley Online Library, p 1
373. Konrádová D, Bon DJ-YD, Pospíšil J (2018) 1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan2-one as a building block in organic synthesis. J Org Chem 83:12229
Jiˇ rí Pospíšil is a Group Leader of the Natural Product Synthesis
Group (pospisilab.com) in the Laboratory of Growth Regulators,
Institute of Experimental Botany ASCR & Palacký University
in Olomouc, Czech Republic (rustreg.upol.cz). He is also an
Associate Professor of Organic Chemistry at the Department
of Organic Chemistry, Faculty of Science, Palacky University
(orgchem.upol.cz). Pospíšil’s current research program focuses
on new organic synthetic strategy development, including the
development of new tunable Brønsted acids for organocatalysis
and the design of various polyfunctional synthetic building
blocks for Diversity Oriented Synthesis, with the aim of
using these in the context of plant secondary metabolite and
phytohormone synthesis. The main target compounds in the
field of natural product synthesis are lignans, neolignans,
and gibberellins. He received his undergraduate education at
Masaryk University in Brno, Czech Republic, where he also
obtained his Master’s degree in organic chemistry under the
guidance of Prof. Milan Potᡠcek. After finishing his initial
J. Pospíšil et al.
360. Jenab M, Thompson LU (1996) The influence of flaxseed and lignans on colon carcinogenesis
and β-glucuronidase activity. Carcinogenesis 17:1343
361. Cheng X, Wang H, Yang J, Cheng Y, Wang D, Yang F, Li Y, Zhou D, Wang Y, Xue Z, Zhang
L, Zhang Q, Yang L, Zhang R, Da D (2018) Arctigenin protects against liver injury from
acute hepatitis by suppressing immune cells in mice. Biomed Pharmacother 102:464
362. Li F, Zhang T, Sun H, Gu H, Wang H, Su X, Li C, Li B, Chen R, Kang J (2017) A new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of Schisandra
chinensis. Molecules 22:1931
363. Wang G-W, Deng L-Q, Luo Y-P, Liao Z-H, Chen M (2017) Hepatoprotective triterpenoids
and lignans from the stems of Schisandra pubescens. Nat Prod Res 31:1855
364. Durazzo A, Lucarini M, Souto EB, Cicala C, Caiazzo E, Izzo AA, Novellino E, Santini A
(2019) Polyphenols: a concise overview on the chemistry, occurrence, and human health.
Phytother Res 33:2221
365. Vinson JA (2019) Intracellular polyphenols: how little we know. J Agric Food Chem 67:3865
366. Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O’Brien J, Renwick AG, Korver
O, Smit F, Walker R (2003) Guidance for the safety assessment of botanicals and botanical
preparations for use in food and food supplements. Food Chem Toxicol 41:1625
367. Ross JA, Potter JD, Robison LL (1994) Infant leukemia, topoisomerase II inhibitors, and the
MLL gene. J Natl Cancer Inst 86:1678
368. Lambert JD, Sang S, Yang CS (2007) Possible controversy over dietary polyphenols: benefits
vs risks. Chem Res Toxicol 20:583
369. Konrádová D, Kozubíková H, Doležal K, Pospíšil J (2017) Microwave-assisted synthesis of
phenylpropanoids and coumarins: total synthesis of osthol. Eur J Org Chem 2017:5204
370. Barbušˇ cáková Z, Kozubíková H, Zálešák F, Doležal K, Pospíšil J (2018) General approach to
neolignan-core of the Boehmenan natural product family. Monatsh Chem – Chem Monthly
149:737
371. Grúz J, Pospíšil J, Kozubíková H, Pospíšil T, Doležal K, Bunzel M, Strnad M (2015) Determination of free diferulic, disinapic and dicoumaric acids in plants and foods. Food Chem
171:280
372. Pospíšil J (2020) 1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one. In: Encyclopedia of
reagents for organic synthesis. Wiley Online Library, p 1
373. Konrádová D, Bon DJ-YD, Pospíšil J (2018) 1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan2-one as a building block in organic synthesis. J Org Chem 83:12229
Jiˇ rí Pospíšil is a Group Leader of the Natural Product Synthesis
Group (pospisilab.com) in the Laboratory of Growth Regulators,
Institute of Experimental Botany ASCR & Palacký University
in Olomouc, Czech Republic (rustreg.upol.cz). He is also an
Associate Professor of Organic Chemistry at the Department
of Organic Chemistry, Faculty of Science, Palacky University
(orgchem.upol.cz). Pospíšil’s current research program focuses
on new organic synthetic strategy development, including the
development of new tunable Brønsted acids for organocatalysis
and the design of various polyfunctional synthetic building
blocks for Diversity Oriented Synthesis, with the aim of
using these in the context of plant secondary metabolite and
phytohormone synthesis. The main target compounds in the
field of natural product synthesis are lignans, neolignans,
and gibberellins. He received his undergraduate education at
Masaryk University in Brno, Czech Republic, where he also
obtained his Master’s degree in organic chemistry under the
guidance of Prof. Milan Potᡠcek. After finishing his initial